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Bidot2008 - Mathematical modelling of T cell activation kinetics Lab

About lab

Mathematical modeling representing Tcell actiavtion regualtion by TCR, IL2 and other players. It can be used to explore immune response dynamics and compare pathway-level behavior across conditions.

Runtime

Duration10
Comms Step1

Runs

Total0
Completed0
Failed0

Metadata

Packagebidot2008-mathematical-modelling-of-t-cell-activation-kinetics-l
Created2026-05-15
Updated2026-05-15
immunologysbmlbiomodels_ebifaithfulcuratedvisualisation

Manifest

{
  "io": {
    "inputs": [
      {
        "name": "initial_cd4_cd8_binding_state",
        "label": "Initial CD4 CD8 Binding State",
        "units": "native source value",
        "default": 40000,
        "maps_to": "immunology_sbml_bidot2008_mathematical_modelling_of_t_cell_activ_model1910290003_model.initial_cd4_cd8_binding_state",
        "description": "Initial CD4 CD8 Binding State. Sets the initial value of bundled SBML species `CD4_8`."
      },
      {
        "name": "initial_cd28_cd80_costimulation_complex",
        "label": "Initial Cd28 Cd80 Costimulation Complex",
        "units": "native source value",
        "default": 1,
        "maps_to": "immunology_sbml_bidot2008_mathematical_modelling_of_t_cell_activ_model1910290003_model.initial_cd28_cd80_costimulation_complex",
        "description": "Initial Cd28 Cd80 Costimulation Complex. Sets the initial value of bundled SBML species `CD28_CD80`."
      },
      {
        "name": "initial_tl_0",
        "label": "Initial Tl 0",
        "units": "native source value",
        "default": 1,
        "maps_to": "immunology_sbml_bidot2008_mathematical_modelling_of_t_cell_activ_model1910290003_model.initial_tl_0",
        "description": "Initial Tl 0. Sets the initial value of bundled SBML species `TL_0`."
      },
      {
        "name": "initial_unresolved_immune_observable_1",
        "label": "Initial Unresolved Immune Observable 1",
        "units": "native source value",
        "default": 1,
        "maps_to": "immunology_sbml_bidot2008_mathematical_modelling_of_t_cell_activ_model1910290003_model.initial_unresolved_immune_observable_1",
        "description": "Initial Unresolved Immune Observable 1. Sets the initial value of bundled SBML species `T_0`."
      },
      {
        "name": "initial_unresolved_immune_observable_2",
        "label": "Initial Unresolved Immune Observable 2",
        "units": "native source value",
        "default": 1,
        "maps_to": "immunology_sbml_bidot2008_mathematical_modelling_of_t_cell_activ_model1910290003_model.initial_unresolved_immune_observable_2",
        "description": "Initial Unresolved Immune Observable 2. Sets the initial value of bundled SBML species `T_i`."
      }
    ],
    "outputs": [
      {
        "name": "cd4_cd8_binding_state",
        "maps_to": "immunology_sbml_bidot2008_mathematical_modelling_of_t_cell_activ_model1910290003_model.cd4_cd8_binding_state"
      },
      {
        "name": "cd28_cd80_costimulation_complex",
        "maps_to": "immunology_sbml_bidot2008_mathematical_modelling_of_t_cell_activ_model1910290003_model.cd28_cd80_costimulation_complex"
      },
      {
        "name": "tl_0",
        "maps_to": "immunology_sbml_bidot2008_mathematical_modelling_of_t_cell_activ_model1910290003_model.tl_0"
      },
      {
        "name": "unresolved_immune_observable_1",
        "maps_to": "immunology_sbml_bidot2008_mathematical_modelling_of_t_cell_activ_model1910290003_model.unresolved_immune_observable_1"
      },
      {
        "name": "unresolved_immune_observable_2",
        "maps_to": "immunology_sbml_bidot2008_mathematical_modelling_of_t_cell_activ_model1910290003_model.unresolved_immune_observable_2"
      },
      {
        "name": "state",
        "maps_to": "immunology_sbml_bidot2008_mathematical_modelling_of_t_cell_activ_model1910290003_model.state"
      },
      {
        "name": "summary",
        "maps_to": "immunology_sbml_bidot2008_mathematical_modelling_of_t_cell_activ_model1910290003_model.summary"
      },
      {
        "name": "species_labels",
        "maps_to": "immunology_sbml_bidot2008_mathematical_modelling_of_t_cell_activ_model1910290003_model.species_labels"
      }
    ]
  },
  "title": "Bidot2008 - Mathematical modelling of T cell activation kinetics Lab",
  "models": [
    {
      "path": "owned/models/immunology_sbml_bidot2008_mathematical_modelling_of_t_cell_activ_model1910290003_model",
      "alias": "immunology_sbml_bidot2008_mathematical_modelling_of_t_cell_activ_model1910290003_model",
      "provenance": {
        "owned_path": "owned/models/immunology_sbml_bidot2008_mathematical_modelling_of_t_cell_activ_model1910290003_model"
      }
    },
    {
      "path": "owned/models/visualisation",
      "alias": "visualisation",
      "provenance": {
        "owned_path": "owned/models/visualisation"
      }
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.immunology_sbml_bidot2008_mathematical_modelling_of_t_cell_activ_model1910290003_model_state"
      ],
      "from": "immunology_sbml_bidot2008_mathematical_modelling_of_t_cell_activ_model1910290003_model.state"
    },
    {
      "to": [
        "visualisation.immunology_sbml_bidot2008_mathematical_modelling_of_t_cell_activ_model1910290003_model_summary"
      ],
      "from": "immunology_sbml_bidot2008_mathematical_modelling_of_t_cell_activ_model1910290003_model.summary"
    },
    {
      "to": [
        "visualisation.immunology_sbml_bidot2008_mathematical_modelling_of_t_cell_activ_model1910290003_model_species_labels"
      ],
      "from": "immunology_sbml_bidot2008_mathematical_modelling_of_t_cell_activ_model1910290003_model.species_labels"
    }
  ],
  "runtime": {
    "duration": 10,
    "initial_inputs": {},
    "communication_step": 1
  },
  "description": "Mathematical modeling representing Tcell actiavtion regualtion by TCR, IL2 and other players. It can be used to explore immune response dynamics and compare pathway-level behavior across conditions.",
  "schema_version": "2.0"
}

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