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Karagiannis2004 Collageniproteolysis Lab

About lab

This a model from the article: A theoretical model of type I collagen proteolysis by matrix metalloproteinase(MMP) 2 and membrane type 1 MMP in the presence of tissue inhibitor ofmetalloproteinase 2. It can be used to explore systemsbiology karagiannis2004 collageniproteolysis model0911270007 dynamics and compare simulation behavior across conditions.

Runtime

Duration1
Comms Step0.1

Runs

Total0
Completed0
Failed0

Metadata

Packagekaragiannis2004-collageniproteolysis-lab
Created2026-05-17
Updated2026-05-17
pharmacologysystemsbiologysbmlbiomodels_ebifaithfulcuratedvisualisation

Manifest

{
  "io": {
    "inputs": [
      {
        "name": "initial_model_state_t2",
        "label": "Initial Model State T2",
        "maps_to": "systemsbiology_sbml_karagiannis2004_collageniproteolysis_model0911270007_model.initial_model_state_t2",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `T2`."
      },
      {
        "name": "initial_mt1t",
        "label": "Initial Mt1t",
        "maps_to": "systemsbiology_sbml_karagiannis2004_collageniproteolysis_model0911270007_model.initial_mt1t",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `MT1t`."
      },
      {
        "name": "initial_mt1cat",
        "label": "Initial Mt1cat",
        "maps_to": "systemsbiology_sbml_karagiannis2004_collageniproteolysis_model0911270007_model.initial_mt1cat",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `MT1cat`."
      },
      {
        "name": "initial_mt1_t2_star",
        "label": "Initial MT1 T2 Star",
        "maps_to": "systemsbiology_sbml_karagiannis2004_collageniproteolysis_model0911270007_model.initial_mt1_t2_star",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `MT1_T2_star`."
      },
      {
        "name": "initial_mt1_t2_m2_p_mt1",
        "label": "Initial MT1 T2 M2 P MT1",
        "maps_to": "systemsbiology_sbml_karagiannis2004_collageniproteolysis_model0911270007_model.initial_mt1_t2_m2_p_mt1",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `MT1_T2_M2p_MT1`."
      },
      {
        "name": "initial_mt1_t2_m2_p",
        "label": "Initial MT1 T2 M2 P",
        "maps_to": "systemsbiology_sbml_karagiannis2004_collageniproteolysis_model0911270007_model.initial_mt1_t2_m2_p",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `MT1_T2_M2p`."
      }
    ],
    "outputs": [
      {
        "name": "state",
        "maps_to": "systemsbiology_sbml_karagiannis2004_collageniproteolysis_model0911270007_model.state"
      },
      {
        "name": "summary",
        "maps_to": "systemsbiology_sbml_karagiannis2004_collageniproteolysis_model0911270007_model.summary"
      },
      {
        "name": "species_labels",
        "maps_to": "systemsbiology_sbml_karagiannis2004_collageniproteolysis_model0911270007_model.species_labels"
      },
      {
        "name": "model_state_t2",
        "maps_to": "systemsbiology_sbml_karagiannis2004_collageniproteolysis_model0911270007_model.model_state_t2"
      },
      {
        "name": "mt1t",
        "maps_to": "systemsbiology_sbml_karagiannis2004_collageniproteolysis_model0911270007_model.mt1t"
      },
      {
        "name": "mt1cat",
        "maps_to": "systemsbiology_sbml_karagiannis2004_collageniproteolysis_model0911270007_model.mt1cat"
      },
      {
        "name": "mt1_t2_star",
        "maps_to": "systemsbiology_sbml_karagiannis2004_collageniproteolysis_model0911270007_model.mt1_t2_star"
      },
      {
        "name": "mt1_t2_m2_p_mt1",
        "maps_to": "systemsbiology_sbml_karagiannis2004_collageniproteolysis_model0911270007_model.mt1_t2_m2_p_mt1"
      },
      {
        "name": "mt1_t2_m2_p",
        "maps_to": "systemsbiology_sbml_karagiannis2004_collageniproteolysis_model0911270007_model.mt1_t2_m2_p"
      }
    ]
  },
  "tags": [
    "pharmacology",
    "systemsbiology",
    "sbml",
    "biomodels_ebi",
    "faithful",
    "curated"
  ],
  "title": "Karagiannis2004 Collageniproteolysis Lab",
  "models": [
    {
      "path": "owned/models/systemsbiology_sbml_karagiannis2004_collageniproteolysis_model0911270007_model",
      "alias": "systemsbiology_sbml_karagiannis2004_collageniproteolysis_model0911270007_model",
      "provenance": {
        "owned_path": "owned/models/systemsbiology_sbml_karagiannis2004_collageniproteolysis_model0911270007_model"
      }
    },
    {
      "path": "owned/models/visualisation",
      "alias": "visualisation",
      "provenance": {
        "owned_path": "owned/models/visualisation"
      }
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.systemsbiology_sbml_karagiannis2004_collageniproteolysis_model0911270007_model_state"
      ],
      "from": "systemsbiology_sbml_karagiannis2004_collageniproteolysis_model0911270007_model.state"
    },
    {
      "to": [
        "visualisation.systemsbiology_sbml_karagiannis2004_collageniproteolysis_model0911270007_model_summary"
      ],
      "from": "systemsbiology_sbml_karagiannis2004_collageniproteolysis_model0911270007_model.summary"
    },
    {
      "to": [
        "visualisation.systemsbiology_sbml_karagiannis2004_collageniproteolysis_model0911270007_model_species_labels"
      ],
      "from": "systemsbiology_sbml_karagiannis2004_collageniproteolysis_model0911270007_model.species_labels"
    }
  ],
  "runtime": {
    "duration": 1,
    "initial_inputs": {},
    "communication_step": 0.1
  },
  "description": "This a model from the article: A theoretical model of type I collagen proteolysis by matrix metalloproteinase(MMP) 2 and membrane type 1 MMP in the presence of tissue inhibitor ofmetalloproteinase 2. It can be used to explore systemsbiology karagiannis2004 collageniproteolysis model0911270007 dynamics and compare simulation behavior across conditions.",
  "schema_version": "2.0"
}

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