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Hat2016 P53 Irradiation Response Lab

About lab

p53 irradiation/cell-fate response. The p53 transcription factor is a regulator of key cellular processes including DNA repair, cell cycle arrest, and apoptosis. In this theoretical study, we investigate how the complex circuitry of the.

Runtime

Duration10
Comms Step1

Runs

Total0
Completed0
Failed0

Metadata

Packagehat2016-p53-irradiation-response-lab
Created2026-05-15
Updated2026-05-15
generegulationsbmlbiomodels_ebifaithfulvisualisation

Manifest

{
  "io": {
    "inputs": [],
    "outputs": [
      {
        "name": "dna_double_strand_breaks",
        "maps_to": "hat2016_p53_irradiation_response.dna_double_strand_breaks"
      },
      {
        "name": "p53_arrester",
        "maps_to": "hat2016_p53_irradiation_response.p53_arrester"
      },
      {
        "name": "p53_killer",
        "maps_to": "hat2016_p53_irradiation_response.p53_killer"
      },
      {
        "name": "mdm2_messenger_rna",
        "maps_to": "hat2016_p53_irradiation_response.mdm2_messenger_rna"
      },
      {
        "name": "state",
        "maps_to": "hat2016_p53_irradiation_response.state"
      },
      {
        "name": "summary",
        "maps_to": "hat2016_p53_irradiation_response.summary"
      },
      {
        "name": "species_labels",
        "maps_to": "hat2016_p53_irradiation_response.species_labels"
      }
    ]
  },
  "title": "Hat2016 P53 Irradiation Response Lab",
  "models": [
    {
      "path": "owned/models/hat2016_p53_irradiation_response",
      "alias": "hat2016_p53_irradiation_response",
      "parameters": {
        "model_path": "data/BIOMD0000000943.xml",
        "integration_step": 0.1
      },
      "provenance": {
        "owned_path": "owned/models/hat2016_p53_irradiation_response"
      }
    },
    {
      "path": "owned/models/visualisation",
      "alias": "visualisation",
      "provenance": {
        "owned_path": "owned/models/visualisation"
      }
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.hat2016_p53_irradiation_response_dna_double_strand_breaks"
      ],
      "from": "hat2016_p53_irradiation_response.dna_double_strand_breaks"
    },
    {
      "to": [
        "visualisation.hat2016_p53_irradiation_response_p53_arrester"
      ],
      "from": "hat2016_p53_irradiation_response.p53_arrester"
    },
    {
      "to": [
        "visualisation.hat2016_p53_irradiation_response_p53_killer"
      ],
      "from": "hat2016_p53_irradiation_response.p53_killer"
    },
    {
      "to": [
        "visualisation.hat2016_p53_irradiation_response_mdm2_messenger_rna"
      ],
      "from": "hat2016_p53_irradiation_response.mdm2_messenger_rna"
    },
    {
      "to": [
        "visualisation.hat2016_p53_irradiation_response_state"
      ],
      "from": "hat2016_p53_irradiation_response.state"
    },
    {
      "to": [
        "visualisation.hat2016_p53_irradiation_response_summary"
      ],
      "from": "hat2016_p53_irradiation_response.summary"
    },
    {
      "to": [
        "visualisation.hat2016_p53_irradiation_response_species_labels"
      ],
      "from": "hat2016_p53_irradiation_response.species_labels"
    }
  ],
  "runtime": {
    "duration": 10,
    "initial_inputs": {},
    "communication_step": 1
  },
  "description": "p53 irradiation/cell-fate response. The p53 transcription factor is a regulator of key cellular processes including DNA repair, cell cycle arrest, and apoptosis. In this theoretical study, we investigate how the complex circuitry of the.",
  "schema_version": "2.0"
}

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