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Willems1991 Simulating Thrombin Generation Lab

About lab

Mathematical model of blood coagulation to simulate factor IIa, Va and Xa concentration profiles. Publication also illustrates the effect of hirudin on factor IIa, Va and Xa generation.

Runtime

Duration1
Comms Step0.1

Runs

Total0
Completed0
Failed0

Metadata

Packagewillems1991-simulating-thrombin-generation-lab
Created2026-05-17
Updated2026-05-17
generegulationsystemsbiologysbmlbiomodels_ebifaithfulcuratedvisualisation

Manifest

{
  "io": {
    "inputs": [
      {
        "name": "initial_xa_atiii",
        "label": "Initial Xa Atiii",
        "maps_to": "systemsbiology_sbml_willems1991_simulating_thrombin_generation_model1807240002_model.initial_xa_atiii",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `Xa_ATIII`."
      },
      {
        "name": "initial_va_inactive",
        "label": "Initial Va Inactive",
        "maps_to": "systemsbiology_sbml_willems1991_simulating_thrombin_generation_model1807240002_model.initial_va_inactive",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `Va_inactive`."
      },
      {
        "name": "initial_va_xa",
        "label": "Initial Va Xa",
        "maps_to": "systemsbiology_sbml_willems1991_simulating_thrombin_generation_model1807240002_model.initial_va_xa",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `Va_Xa`."
      },
      {
        "name": "initial_i_ia_hirudin",
        "label": "Initial I Ia Hirudin",
        "maps_to": "systemsbiology_sbml_willems1991_simulating_thrombin_generation_model1807240002_model.initial_i_ia_hirudin",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `IIa_Hirudin`."
      },
      {
        "name": "initial_i_ia_atiii",
        "label": "Initial I Ia Atiii",
        "maps_to": "systemsbiology_sbml_willems1991_simulating_thrombin_generation_model1807240002_model.initial_i_ia_atiii",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `IIa_ATIII`."
      },
      {
        "name": "initial_apc_inactive",
        "label": "Initial Apc Inactive",
        "maps_to": "systemsbiology_sbml_willems1991_simulating_thrombin_generation_model1807240002_model.initial_apc_inactive",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `APC_inactive`."
      }
    ],
    "outputs": [
      {
        "name": "state",
        "maps_to": "systemsbiology_sbml_willems1991_simulating_thrombin_generation_model1807240002_model.state"
      },
      {
        "name": "summary",
        "maps_to": "systemsbiology_sbml_willems1991_simulating_thrombin_generation_model1807240002_model.summary"
      },
      {
        "name": "species_labels",
        "maps_to": "systemsbiology_sbml_willems1991_simulating_thrombin_generation_model1807240002_model.species_labels"
      },
      {
        "name": "xa_atiii",
        "maps_to": "systemsbiology_sbml_willems1991_simulating_thrombin_generation_model1807240002_model.xa_atiii"
      },
      {
        "name": "va_inactive",
        "maps_to": "systemsbiology_sbml_willems1991_simulating_thrombin_generation_model1807240002_model.va_inactive"
      },
      {
        "name": "va_xa",
        "maps_to": "systemsbiology_sbml_willems1991_simulating_thrombin_generation_model1807240002_model.va_xa"
      },
      {
        "name": "i_ia_hirudin",
        "maps_to": "systemsbiology_sbml_willems1991_simulating_thrombin_generation_model1807240002_model.i_ia_hirudin"
      },
      {
        "name": "i_ia_atiii",
        "maps_to": "systemsbiology_sbml_willems1991_simulating_thrombin_generation_model1807240002_model.i_ia_atiii"
      },
      {
        "name": "apc_inactive",
        "maps_to": "systemsbiology_sbml_willems1991_simulating_thrombin_generation_model1807240002_model.apc_inactive"
      }
    ]
  },
  "tags": [
    "generegulation",
    "systemsbiology",
    "sbml",
    "biomodels_ebi",
    "faithful",
    "curated"
  ],
  "title": "Willems1991 Simulating Thrombin Generation Lab",
  "models": [
    {
      "path": "owned/models/systemsbiology_sbml_willems1991_simulating_thrombin_generation_model1807240002_model",
      "alias": "systemsbiology_sbml_willems1991_simulating_thrombin_generation_model1807240002_model",
      "provenance": {
        "owned_path": "owned/models/systemsbiology_sbml_willems1991_simulating_thrombin_generation_model1807240002_model"
      }
    },
    {
      "path": "owned/models/visualisation",
      "alias": "visualisation",
      "provenance": {
        "owned_path": "owned/models/visualisation"
      }
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.systemsbiology_sbml_willems1991_simulating_thrombin_generation_model1807240002_model_state"
      ],
      "from": "systemsbiology_sbml_willems1991_simulating_thrombin_generation_model1807240002_model.state"
    },
    {
      "to": [
        "visualisation.systemsbiology_sbml_willems1991_simulating_thrombin_generation_model1807240002_model_summary"
      ],
      "from": "systemsbiology_sbml_willems1991_simulating_thrombin_generation_model1807240002_model.summary"
    },
    {
      "to": [
        "visualisation.systemsbiology_sbml_willems1991_simulating_thrombin_generation_model1807240002_model_species_labels"
      ],
      "from": "systemsbiology_sbml_willems1991_simulating_thrombin_generation_model1807240002_model.species_labels"
    }
  ],
  "runtime": {
    "duration": 1,
    "initial_inputs": {},
    "communication_step": 0.1
  },
  "description": "Mathematical model of blood coagulation to simulate factor IIa, Va and Xa concentration profiles. Publication also illustrates the effect of hirudin on factor IIa, Va and Xa generation.",
  "schema_version": "2.0"
}

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