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Proctor2017 Role Of Micrornas In Osteoarthritis Lab

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Proctor2017- Role of microRNAs in osteoarthritis (Mir140-IGFBP5 incoherent feed forward) This model is described in the article: Computer simulation models as a tool to investigate the role of microRN. It can be used to explore systemsbiology proctor2017 role of micrornas in dynamics and compare simulation behavior across conditions.

Runtime

Duration1
Comms Step0.1

Runs

Total0
Completed0
Failed0

Metadata

Packageproctor2017-role-of-micrornas-in-osteoarthritis-lab
Created2026-05-17
Updated2026-05-17
generegulationsystemsbiologysbmlbiomodels_ebifaithfulcuratedvisualisation

Manifest

{
  "io": {
    "inputs": [
      {
        "name": "initial_tn_fa",
        "label": "Initial Tn Fa",
        "maps_to": "systemsbiology_sbml_proctor2017_role_of_micrornas_in_osteoarthritis_model1705170004_model.initial_tn_fa",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `TNFa`."
      },
      {
        "name": "initial_ik_b_n_fk_b",
        "label": "Initial Ik B N Fk B",
        "maps_to": "systemsbiology_sbml_proctor2017_role_of_micrornas_in_osteoarthritis_model1705170004_model.initial_ik_b_n_fk_b",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `IkB_NFkB`."
      },
      {
        "name": "initial_n_fk_b",
        "label": "Initial N Fk B",
        "maps_to": "systemsbiology_sbml_proctor2017_role_of_micrornas_in_osteoarthritis_model1705170004_model.initial_n_fk_b",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `NFkB`."
      },
      {
        "name": "initial_mi_r140_gene_n_fk_b",
        "label": "Initial Mi R140 Gene N Fk B",
        "maps_to": "systemsbiology_sbml_proctor2017_role_of_micrornas_in_osteoarthritis_model1705170004_model.initial_mi_r140_gene_n_fk_b",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `miR140_gene_NFkB`."
      },
      {
        "name": "initial_igf1",
        "label": "Initial Igf1",
        "maps_to": "systemsbiology_sbml_proctor2017_role_of_micrornas_in_osteoarthritis_model1705170004_model.initial_igf1",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `IGF1`."
      },
      {
        "name": "initial_mi_r140",
        "label": "Initial Mi R140",
        "maps_to": "systemsbiology_sbml_proctor2017_role_of_micrornas_in_osteoarthritis_model1705170004_model.initial_mi_r140",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `miR140`."
      }
    ],
    "outputs": [
      {
        "name": "state",
        "maps_to": "systemsbiology_sbml_proctor2017_role_of_micrornas_in_osteoarthritis_model1705170004_model.state"
      },
      {
        "name": "summary",
        "maps_to": "systemsbiology_sbml_proctor2017_role_of_micrornas_in_osteoarthritis_model1705170004_model.summary"
      },
      {
        "name": "species_labels",
        "maps_to": "systemsbiology_sbml_proctor2017_role_of_micrornas_in_osteoarthritis_model1705170004_model.species_labels"
      },
      {
        "name": "tn_fa",
        "maps_to": "systemsbiology_sbml_proctor2017_role_of_micrornas_in_osteoarthritis_model1705170004_model.tn_fa"
      },
      {
        "name": "ik_b_n_fk_b",
        "maps_to": "systemsbiology_sbml_proctor2017_role_of_micrornas_in_osteoarthritis_model1705170004_model.ik_b_n_fk_b"
      },
      {
        "name": "n_fk_b",
        "maps_to": "systemsbiology_sbml_proctor2017_role_of_micrornas_in_osteoarthritis_model1705170004_model.n_fk_b"
      },
      {
        "name": "mi_r140_gene_n_fk_b",
        "maps_to": "systemsbiology_sbml_proctor2017_role_of_micrornas_in_osteoarthritis_model1705170004_model.mi_r140_gene_n_fk_b"
      },
      {
        "name": "igf1",
        "maps_to": "systemsbiology_sbml_proctor2017_role_of_micrornas_in_osteoarthritis_model1705170004_model.igf1"
      },
      {
        "name": "mi_r140",
        "maps_to": "systemsbiology_sbml_proctor2017_role_of_micrornas_in_osteoarthritis_model1705170004_model.mi_r140"
      }
    ]
  },
  "tags": [
    "generegulation",
    "systemsbiology",
    "sbml",
    "biomodels_ebi",
    "faithful",
    "curated"
  ],
  "title": "Proctor2017 Role Of Micrornas In Osteoarthritis Lab",
  "models": [
    {
      "path": "owned/models/systemsbiology_sbml_proctor2017_role_of_micrornas_in_osteoarthritis_model1705170004_model",
      "alias": "systemsbiology_sbml_proctor2017_role_of_micrornas_in_osteoarthritis_model1705170004_model",
      "provenance": {
        "owned_path": "owned/models/systemsbiology_sbml_proctor2017_role_of_micrornas_in_osteoarthritis_model1705170004_model"
      }
    },
    {
      "path": "owned/models/visualisation",
      "alias": "visualisation",
      "provenance": {
        "owned_path": "owned/models/visualisation"
      }
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.systemsbiology_sbml_proctor2017_role_of_micrornas_in_osteoarthritis_model1705170004_model_state"
      ],
      "from": "systemsbiology_sbml_proctor2017_role_of_micrornas_in_osteoarthritis_model1705170004_model.state"
    },
    {
      "to": [
        "visualisation.systemsbiology_sbml_proctor2017_role_of_micrornas_in_osteoarthritis_model1705170004_model_summary"
      ],
      "from": "systemsbiology_sbml_proctor2017_role_of_micrornas_in_osteoarthritis_model1705170004_model.summary"
    },
    {
      "to": [
        "visualisation.systemsbiology_sbml_proctor2017_role_of_micrornas_in_osteoarthritis_model1705170004_model_species_labels"
      ],
      "from": "systemsbiology_sbml_proctor2017_role_of_micrornas_in_osteoarthritis_model1705170004_model.species_labels"
    }
  ],
  "runtime": {
    "duration": 1,
    "initial_inputs": {},
    "communication_step": 0.1
  },
  "description": "Proctor2017- Role of microRNAs in osteoarthritis (Mir140-IGFBP5 incoherent feed forward) This model is described in the article: Computer simulation models as a tool to investigate the role of microRN. It can be used to explore systemsbiology proctor2017 role of micrornas in dynamics and compare simulation behavior across conditions.",
  "schema_version": "2.0"
}

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