About lab
Irreversible embryonic stem-cell transcriptional switch executed directly from the bundled SBML source.
Runtime
Duration10
Comms Step1
Runs
Total0
Completed0
Failed0
Metadata
Packagechickarmane2006-irreversible-stem-cell-switch-lab
Created2026-05-15
Updated2026-05-15
developmentsbmltelluriumfaithfulvisualisation
Manifest
{
"io": {
"inputs": [
{
"name": "p53_signal",
"label": "p53 signal",
"units": "native SBML value",
"default": 0,
"maps_to": "chickarmane2006_irreversible_switch.p53_signal",
"description": "Sets the fixed p53 boundary signal used by the stem-cell switch reactions. Maps to SBML symbol `p53`."
}
],
"outputs": [
{
"name": "octamer_binding_transcription_factor_4",
"label": "OCT4",
"maps_to": "chickarmane2006_irreversible_switch.octamer_binding_transcription_factor_4",
"description": "OCT4. Maps to SBML symbol `OCT4`."
},
{
"name": "sry_box_transcription_factor_2",
"label": "SOX2",
"maps_to": "chickarmane2006_irreversible_switch.sry_box_transcription_factor_2",
"description": "SOX2. Maps to SBML symbol `SOX2`."
},
{
"name": "nanog_homeobox",
"label": "NANOG",
"maps_to": "chickarmane2006_irreversible_switch.nanog_homeobox",
"description": "NANOG. Maps to SBML symbol `NANOG`."
},
{
"name": "octamer_binding_transcription_factor_4_sry_box_transcription_factor_2_complex",
"label": "OCT4-SOX2 complex",
"maps_to": "chickarmane2006_irreversible_switch.octamer_binding_transcription_factor_4_sry_box_transcription_factor_2_complex",
"description": "OCT4-SOX2 complex. Maps to SBML symbol `OCT4_SOX2`."
},
{
"name": "differentiation_protein",
"label": "Differentiation protein",
"maps_to": "chickarmane2006_irreversible_switch.differentiation_protein",
"description": "Differentiation protein. Maps to SBML symbol `Protein`."
},
{
"name": "state",
"maps_to": "chickarmane2006_irreversible_switch.state",
"description": "Full friendly observable record."
},
{
"name": "summary",
"maps_to": "chickarmane2006_irreversible_switch.summary",
"description": "Core model run summary."
},
{
"name": "species_labels",
"maps_to": "chickarmane2006_irreversible_switch.species_labels",
"description": "Friendly observable display labels."
}
]
},
"title": "Chickarmane2006 Irreversible Stem Cell Switch Lab",
"models": [
{
"path": "owned/models/chickarmane2006_irreversible_switch",
"alias": "chickarmane2006_irreversible_switch",
"parameters": {
"model_path": "data/BIOMD0000000204.xml",
"integration_step": 0.1
},
"provenance": {
"owned_path": "owned/models/chickarmane2006_irreversible_switch"
}
},
{
"path": "owned/models/visualisation",
"alias": "visualisation",
"provenance": {
"owned_path": "owned/models/visualisation"
}
}
],
"wiring": [
{
"to": [
"visualisation.core_state"
],
"from": "chickarmane2006_irreversible_switch.state"
},
{
"to": [
"visualisation.core_summary"
],
"from": "chickarmane2006_irreversible_switch.summary"
},
{
"to": [
"visualisation.core_species_labels"
],
"from": "chickarmane2006_irreversible_switch.species_labels"
}
],
"runtime": {
"duration": 10,
"initial_inputs": {},
"communication_step": 1
},
"description": "Irreversible embryonic stem-cell transcriptional switch executed directly from the bundled SBML source.",
"schema_version": "2.0"
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