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A Quantitative Model Of The Initiation Of Dna Replication In Saccharomyces Cerevisiae Pr Lab

About lab

Requires input from Chen2004(BIOMD0000000056) model but did not work correctly even after integrating both models. It can be used to explore systemsbiology a quantitative of the initiation dynamics and compare simulation behavior across conditions.

Runtime

Duration1
Comms Step0.1

Runs

Total0
Completed0
Failed0

Metadata

Packagea-quantitative-model-of-the-initiation-of-dna-replication-in-sac
Created2026-05-17
Updated2026-05-17
systemsbiologysbmlbiomodels_ebifaithfulcuratedvisualisation

Manifest

{
  "io": {
    "inputs": [
      {
        "name": "initial_orc_total",
        "label": "Initial Orc Total",
        "maps_to": "systemsbiology_sbml_a_quantitative_model_of_the_initiation_of_dna_re_model1812050001_model.initial_orc_total",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `ORC_Total`."
      },
      {
        "name": "initial_mcm_total",
        "label": "Initial Mcm Total",
        "maps_to": "systemsbiology_sbml_a_quantitative_model_of_the_initiation_of_dna_re_model1812050001_model.initial_mcm_total",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `MCM_Total`."
      },
      {
        "name": "initial_cdt1_total",
        "label": "Initial Cdt1 Total",
        "maps_to": "systemsbiology_sbml_a_quantitative_model_of_the_initiation_of_dna_re_model1812050001_model.initial_cdt1_total",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `CDT1_Total`."
      },
      {
        "name": "initial_cdc45_total",
        "label": "Initial Cdc45 Total",
        "maps_to": "systemsbiology_sbml_a_quantitative_model_of_the_initiation_of_dna_re_model1812050001_model.initial_cdc45_total",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `CDC45_Total`."
      },
      {
        "name": "initial_orc_p",
        "label": "Initial Orc P",
        "maps_to": "systemsbiology_sbml_a_quantitative_model_of_the_initiation_of_dna_re_model1812050001_model.initial_orc_p",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `ORC_P`."
      },
      {
        "name": "initial_orc_mcm_dbf4_cdc45",
        "label": "Initial Orc Mcm Dbf4 Cdc45",
        "maps_to": "systemsbiology_sbml_a_quantitative_model_of_the_initiation_of_dna_re_model1812050001_model.initial_orc_mcm_dbf4_cdc45",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `ORC_MCM_DBF4_CDC45`."
      }
    ],
    "outputs": [
      {
        "name": "state",
        "maps_to": "systemsbiology_sbml_a_quantitative_model_of_the_initiation_of_dna_re_model1812050001_model.state"
      },
      {
        "name": "summary",
        "maps_to": "systemsbiology_sbml_a_quantitative_model_of_the_initiation_of_dna_re_model1812050001_model.summary"
      },
      {
        "name": "species_labels",
        "maps_to": "systemsbiology_sbml_a_quantitative_model_of_the_initiation_of_dna_re_model1812050001_model.species_labels"
      },
      {
        "name": "orc_total",
        "maps_to": "systemsbiology_sbml_a_quantitative_model_of_the_initiation_of_dna_re_model1812050001_model.orc_total"
      },
      {
        "name": "mcm_total",
        "maps_to": "systemsbiology_sbml_a_quantitative_model_of_the_initiation_of_dna_re_model1812050001_model.mcm_total"
      },
      {
        "name": "cdt1_total",
        "maps_to": "systemsbiology_sbml_a_quantitative_model_of_the_initiation_of_dna_re_model1812050001_model.cdt1_total"
      },
      {
        "name": "cdc45_total",
        "maps_to": "systemsbiology_sbml_a_quantitative_model_of_the_initiation_of_dna_re_model1812050001_model.cdc45_total"
      },
      {
        "name": "orc_p",
        "maps_to": "systemsbiology_sbml_a_quantitative_model_of_the_initiation_of_dna_re_model1812050001_model.orc_p"
      },
      {
        "name": "orc_mcm_dbf4_cdc45",
        "maps_to": "systemsbiology_sbml_a_quantitative_model_of_the_initiation_of_dna_re_model1812050001_model.orc_mcm_dbf4_cdc45"
      }
    ]
  },
  "tags": [
    "systemsbiology",
    "sbml",
    "biomodels_ebi",
    "faithful",
    "curated"
  ],
  "title": "A Quantitative Model Of The Initiation Of Dna Replication In Saccharomyces Cerevisiae Pr Lab",
  "models": [
    {
      "path": "owned/models/systemsbiology_sbml_a_quantitative_model_of_the_initiation_of_dna_re_model1812050001_model",
      "alias": "systemsbiology_sbml_a_quantitative_model_of_the_initiation_of_dna_re_model1812050001_model",
      "provenance": {
        "owned_path": "owned/models/systemsbiology_sbml_a_quantitative_model_of_the_initiation_of_dna_re_model1812050001_model"
      }
    },
    {
      "path": "owned/models/visualisation",
      "alias": "visualisation",
      "provenance": {
        "owned_path": "owned/models/visualisation"
      }
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.systemsbiology_sbml_a_quantitative_model_of_the_initiation_of_dna_re_model1812050001_model_state"
      ],
      "from": "systemsbiology_sbml_a_quantitative_model_of_the_initiation_of_dna_re_model1812050001_model.state"
    },
    {
      "to": [
        "visualisation.systemsbiology_sbml_a_quantitative_model_of_the_initiation_of_dna_re_model1812050001_model_summary"
      ],
      "from": "systemsbiology_sbml_a_quantitative_model_of_the_initiation_of_dna_re_model1812050001_model.summary"
    },
    {
      "to": [
        "visualisation.systemsbiology_sbml_a_quantitative_model_of_the_initiation_of_dna_re_model1812050001_model_species_labels"
      ],
      "from": "systemsbiology_sbml_a_quantitative_model_of_the_initiation_of_dna_re_model1812050001_model.species_labels"
    }
  ],
  "runtime": {
    "duration": 1,
    "initial_inputs": {},
    "communication_step": 0.1
  },
  "description": "Requires input from Chen2004(BIOMD0000000056) model but did not work correctly even after integrating both models. It can be used to explore systemsbiology a quantitative of the initiation dynamics and compare simulation behavior across conditions.",
  "schema_version": "2.0"
}

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