Gérard - 2019 - Coupling the cell cycle and the cell transformation networks (SBML) Lab

{
  "io": {
    "inputs": [],
    "outputs": [
      {
        "name": "nf_k_b_0_00045",
        "label": "NF-kB = 0 00045",
        "maps_to": "cellcycle_sbml_g_rard_2019_coupling_the_cell_cycle_and_the_cell_model1906070001_model.nf_k_b_0_00045",
        "description": "Tracks NF-kB = 0 00045 in the lab model via `cellcycle_sbml_g_rard_2019_coupling_the_cell_cycle_and_the_cell_model1906070001_model.nf_k_b_0_00045`."
      },
      {
        "name": "lin28_0_34",
        "label": "LIN28 = 0 34",
        "maps_to": "cellcycle_sbml_g_rard_2019_coupling_the_cell_cycle_and_the_cell_model1906070001_model.lin28_0_34",
        "description": "Tracks LIN28 = 0 34 in the lab model via `cellcycle_sbml_g_rard_2019_coupling_the_cell_cycle_and_the_cell_model1906070001_model.lin28_0_34`."
      },
      {
        "name": "let_7_40",
        "label": "let-7 = 40",
        "maps_to": "cellcycle_sbml_g_rard_2019_coupling_the_cell_cycle_and_the_cell_model1906070001_model.let_7_40",
        "description": "Tracks let-7 = 40 in the lab model via `cellcycle_sbml_g_rard_2019_coupling_the_cell_cycle_and_the_cell_model1906070001_model.let_7_40`."
      },
      {
        "name": "model_state_m_il6_0_0003",
        "label": "Model state M IL6 = 0 0003",
        "maps_to": "cellcycle_sbml_g_rard_2019_coupling_the_cell_cycle_and_the_cell_model1906070001_model.model_state_m_il6_0_0003",
        "description": "Tracks Model state M IL6 = 0 0003 in the lab model via `cellcycle_sbml_g_rard_2019_coupling_the_cell_cycle_and_the_cell_model1906070001_model.model_state_m_il6_0_0003`."
      },
      {
        "name": "model_state_m_il6let7",
        "label": "Model state M IL6let7",
        "maps_to": "cellcycle_sbml_g_rard_2019_coupling_the_cell_cycle_and_the_cell_model1906070001_model.model_state_m_il6let7",
        "description": "Tracks Model state M IL6let7 in the lab model via `cellcycle_sbml_g_rard_2019_coupling_the_cell_cycle_and_the_cell_model1906070001_model.model_state_m_il6let7`."
      },
      {
        "name": "il6_0_001",
        "label": "IL6 = 0 001",
        "maps_to": "cellcycle_sbml_g_rard_2019_coupling_the_cell_cycle_and_the_cell_model1906070001_model.il6_0_001",
        "description": "Tracks IL6 = 0 001 in the lab model via `cellcycle_sbml_g_rard_2019_coupling_the_cell_cycle_and_the_cell_model1906070001_model.il6_0_001`."
      },
      {
        "name": "model_state_m_ras_0_00001",
        "label": "Model state M Ras = 0 00001",
        "maps_to": "cellcycle_sbml_g_rard_2019_coupling_the_cell_cycle_and_the_cell_model1906070001_model.model_state_m_ras_0_00001",
        "description": "Tracks Model state M Ras = 0 00001 in the lab model via `cellcycle_sbml_g_rard_2019_coupling_the_cell_cycle_and_the_cell_model1906070001_model.model_state_m_ras_0_00001`."
      },
      {
        "name": "model_state_m_raslet7",
        "label": "Model state M Raslet7",
        "maps_to": "cellcycle_sbml_g_rard_2019_coupling_the_cell_cycle_and_the_cell_model1906070001_model.model_state_m_raslet7",
        "description": "Tracks Model state M Raslet7 in the lab model via `cellcycle_sbml_g_rard_2019_coupling_the_cell_cycle_and_the_cell_model1906070001_model.model_state_m_raslet7`."
      },
      {
        "name": "ras_0_0001",
        "label": "Ras = 0 0001",
        "maps_to": "cellcycle_sbml_g_rard_2019_coupling_the_cell_cycle_and_the_cell_model1906070001_model.ras_0_0001",
        "description": "Tracks Ras = 0 0001 in the lab model via `cellcycle_sbml_g_rard_2019_coupling_the_cell_cycle_and_the_cell_model1906070001_model.ras_0_0001`."
      },
      {
        "name": "stat3_0_0001",
        "label": "STAT3 = 0 0001",
        "maps_to": "cellcycle_sbml_g_rard_2019_coupling_the_cell_cycle_and_the_cell_model1906070001_model.stat3_0_0001",
        "description": "Tracks STAT3 = 0 0001 in the lab model via `cellcycle_sbml_g_rard_2019_coupling_the_cell_cycle_and_the_cell_model1906070001_model.stat3_0_0001`."
      },
      {
        "name": "mi_model_state_r21_0_0003",
        "label": "Mi Model state R21 = 0 0003",
        "maps_to": "cellcycle_sbml_g_rard_2019_coupling_the_cell_cycle_and_the_cell_model1906070001_model.mi_model_state_r21_0_0003",
        "description": "Tracks Mi Model state R21 = 0 0003 in the lab model via `cellcycle_sbml_g_rard_2019_coupling_the_cell_cycle_and_the_cell_model1906070001_model.mi_model_state_r21_0_0003`."
      },
      {
        "name": "model_state_m_pten_0_01",
        "label": "Model state M PTEN = 0 01",
        "maps_to": "cellcycle_sbml_g_rard_2019_coupling_the_cell_cycle_and_the_cell_model1906070001_model.model_state_m_pten_0_01",
        "description": "Tracks Model state M PTEN = 0 01 in the lab model via `cellcycle_sbml_g_rard_2019_coupling_the_cell_cycle_and_the_cell_model1906070001_model.model_state_m_pten_0_01`."
      },
      {
        "name": "mi_rmpten",
        "label": "Mi Rmpten",
        "maps_to": "cellcycle_sbml_g_rard_2019_coupling_the_cell_cycle_and_the_cell_model1906070001_model.mi_rmpten",
        "description": "Tracks Mi Rmpten in the lab model via `cellcycle_sbml_g_rard_2019_coupling_the_cell_cycle_and_the_cell_model1906070001_model.mi_rmpten`."
      },
      {
        "name": "pten_0_17",
        "label": "PTEN = 0 17",
        "maps_to": "cellcycle_sbml_g_rard_2019_coupling_the_cell_cycle_and_the_cell_model1906070001_model.pten_0_17",
        "description": "Tracks PTEN = 0 17 in the lab model via `cellcycle_sbml_g_rard_2019_coupling_the_cell_cycle_and_the_cell_model1906070001_model.pten_0_17`."
      },
      {
        "name": "model_state_m_md",
        "label": "Model state M Md",
        "maps_to": "cellcycle_sbml_g_rard_2019_coupling_the_cell_cycle_and_the_cell_model1906070001_model.model_state_m_md",
        "description": "Tracks Model state M Md in the lab model via `cellcycle_sbml_g_rard_2019_coupling_the_cell_cycle_and_the_cell_model1906070001_model.model_state_m_md`."
      },
      {
        "name": "md_0_01",
        "label": "Md = 0 01",
        "maps_to": "cellcycle_sbml_g_rard_2019_coupling_the_cell_cycle_and_the_cell_model1906070001_model.md_0_01",
        "description": "Tracks Md = 0 01 in the lab model via `cellcycle_sbml_g_rard_2019_coupling_the_cell_cycle_and_the_cell_model1906070001_model.md_0_01`."
      },
      {
        "name": "model_state_m_mdlet7",
        "label": "Model state M Mdlet7",
        "maps_to": "cellcycle_sbml_g_rard_2019_coupling_the_cell_cycle_and_the_cell_model1906070001_model.model_state_m_mdlet7",
        "description": "Tracks Model state M Mdlet7 in the lab model via `cellcycle_sbml_g_rard_2019_coupling_the_cell_cycle_and_the_cell_model1906070001_model.model_state_m_mdlet7`."
      },
      {
        "name": "e2f_transcription_factor",
        "label": "E2F transcription factor",
        "maps_to": "cellcycle_sbml_g_rard_2019_coupling_the_cell_cycle_and_the_cell_model1906070001_model.e2f_transcription_factor",
        "description": "Tracks E2F transcription factor in the lab model via `cellcycle_sbml_g_rard_2019_coupling_the_cell_cycle_and_the_cell_model1906070001_model.e2f_transcription_factor`."
      },
      {
        "name": "model_state_m_me",
        "label": "Model state M Me",
        "maps_to": "cellcycle_sbml_g_rard_2019_coupling_the_cell_cycle_and_the_cell_model1906070001_model.model_state_m_me",
        "description": "Tracks Model state M Me in the lab model via `cellcycle_sbml_g_rard_2019_coupling_the_cell_cycle_and_the_cell_model1906070001_model.model_state_m_me`."
      },
      {
        "name": "me_0_01",
        "label": "Me = 0 01",
        "maps_to": "cellcycle_sbml_g_rard_2019_coupling_the_cell_cycle_and_the_cell_model1906070001_model.me_0_01",
        "description": "Tracks Me = 0 01 in the lab model via `cellcycle_sbml_g_rard_2019_coupling_the_cell_cycle_and_the_cell_model1906070001_model.me_0_01`."
      },
      {
        "name": "model_state_m_melet7",
        "label": "Model state M Melet7",
        "maps_to": "cellcycle_sbml_g_rard_2019_coupling_the_cell_cycle_and_the_cell_model1906070001_model.model_state_m_melet7",
        "description": "Tracks Model state M Melet7 in the lab model via `cellcycle_sbml_g_rard_2019_coupling_the_cell_cycle_and_the_cell_model1906070001_model.model_state_m_melet7`."
      },
      {
        "name": "model_state_m_ma",
        "label": "Model state M Ma",
        "maps_to": "cellcycle_sbml_g_rard_2019_coupling_the_cell_cycle_and_the_cell_model1906070001_model.model_state_m_ma",
        "description": "Tracks Model state M Ma in the lab model via `cellcycle_sbml_g_rard_2019_coupling_the_cell_cycle_and_the_cell_model1906070001_model.model_state_m_ma`."
      },
      {
        "name": "ma_0_01",
        "label": "Ma = 0 01",
        "maps_to": "cellcycle_sbml_g_rard_2019_coupling_the_cell_cycle_and_the_cell_model1906070001_model.ma_0_01",
        "description": "Tracks Ma = 0 01 in the lab model via `cellcycle_sbml_g_rard_2019_coupling_the_cell_cycle_and_the_cell_model1906070001_model.ma_0_01`."
      },
      {
        "name": "model_state_m_malet7",
        "label": "Model state M Malet7",
        "maps_to": "cellcycle_sbml_g_rard_2019_coupling_the_cell_cycle_and_the_cell_model1906070001_model.model_state_m_malet7",
        "description": "Tracks Model state M Malet7 in the lab model via `cellcycle_sbml_g_rard_2019_coupling_the_cell_cycle_and_the_cell_model1906070001_model.model_state_m_malet7`."
      },
      {
        "name": "model_state_m_mb",
        "label": "Model state M Mb",
        "maps_to": "cellcycle_sbml_g_rard_2019_coupling_the_cell_cycle_and_the_cell_model1906070001_model.model_state_m_mb",
        "description": "Tracks Model state M Mb in the lab model via `cellcycle_sbml_g_rard_2019_coupling_the_cell_cycle_and_the_cell_model1906070001_model.model_state_m_mb`."
      },
      {
        "name": "mb_0_01",
        "label": "Mb = 0 01",
        "maps_to": "cellcycle_sbml_g_rard_2019_coupling_the_cell_cycle_and_the_cell_model1906070001_model.mb_0_01",
        "description": "Tracks Mb = 0 01 in the lab model via `cellcycle_sbml_g_rard_2019_coupling_the_cell_cycle_and_the_cell_model1906070001_model.mb_0_01`."
      },
      {
        "name": "model_state_m_mblet7",
        "label": "Model state M Mblet7",
        "maps_to": "cellcycle_sbml_g_rard_2019_coupling_the_cell_cycle_and_the_cell_model1906070001_model.model_state_m_mblet7",
        "description": "Tracks Model state M Mblet7 in the lab model via `cellcycle_sbml_g_rard_2019_coupling_the_cell_cycle_and_the_cell_model1906070001_model.model_state_m_mblet7`."
      },
      {
        "name": "apc_c_c_0_01",
        "label": "APC/C/C = 0 01",
        "maps_to": "cellcycle_sbml_g_rard_2019_coupling_the_cell_cycle_and_the_cell_model1906070001_model.apc_c_c_0_01",
        "description": "Tracks APC/C/C = 0 01 in the lab model via `cellcycle_sbml_g_rard_2019_coupling_the_cell_cycle_and_the_cell_model1906070001_model.apc_c_c_0_01`."
      },
      {
        "name": "total_let_7_micro_rna",
        "label": "Total let-7 microRNA",
        "maps_to": "cellcycle_sbml_g_rard_2019_coupling_the_cell_cycle_and_the_cell_model1906070001_model.total_let_7_micro_rna",
        "description": "Tracks Total let-7 microRNA in the lab model via `cellcycle_sbml_g_rard_2019_coupling_the_cell_cycle_and_the_cell_model1906070001_model.total_let_7_micro_rna`."
      },
      {
        "name": "inactive_nf_k_b",
        "label": "Inactive NF-kB",
        "maps_to": "cellcycle_sbml_g_rard_2019_coupling_the_cell_cycle_and_the_cell_model1906070001_model.inactive_nf_k_b",
        "description": "Tracks Inactive NF-kB in the lab model via `cellcycle_sbml_g_rard_2019_coupling_the_cell_cycle_and_the_cell_model1906070001_model.inactive_nf_k_b`."
      },
      {
        "name": "model_time",
        "label": "Model Time",
        "maps_to": "cellcycle_sbml_g_rard_2019_coupling_the_cell_cycle_and_the_cell_model1906070001_model.model_time",
        "description": "Tracks Model Time in the lab model via `cellcycle_sbml_g_rard_2019_coupling_the_cell_cycle_and_the_cell_model1906070001_model.model_time`."
      }
    ]
  },
  "title": "Gérard - 2019 - Coupling the cell cycle and the cell transformation networks (SBML) Lab",
  "models": [
    {
      "path": "models/core",
      "alias": "cellcycle_sbml_g_rard_2019_coupling_the_cell_cycle_and_the_cell_model1906070001_model"
    },
    {
      "path": "models/visualisation",
      "alias": "visualisation"
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.cellcycle_sbml_g_rard_2019_coupling_the_cell_cycle_and_the_cell_model1906070001_model_state"
      ],
      "from": "cellcycle_sbml_g_rard_2019_coupling_the_cell_cycle_and_the_cell_model1906070001_model.state"
    },
    {
      "to": [
        "visualisation.cellcycle_sbml_g_rard_2019_coupling_the_cell_cycle_and_the_cell_model1906070001_model_summary"
      ],
      "from": "cellcycle_sbml_g_rard_2019_coupling_the_cell_cycle_and_the_cell_model1906070001_model.summary"
    },
    {
      "to": [
        "visualisation.cellcycle_sbml_g_rard_2019_coupling_the_cell_cycle_and_the_cell_model1906070001_model_species_labels"
      ],
      "from": "cellcycle_sbml_g_rard_2019_coupling_the_cell_cycle_and_the_cell_model1906070001_model.species_labels"
    }
  ],
  "package": "gerard2019-cell-cycle-transformation",
  "runtime": {
    "duration": 10,
    "initial_inputs": {},
    "communication_step": 1
  },
  "version": "1.0.0",
  "description": "Single-model lab wrapper for Gérard - 2019 - Coupling the cell cycle and the cell transformation networks (SBML). Model for the Let-7-mediated coupling between the CDK network driving the cell cycle and the malignant cell transformation network. It can be used to explore cell-cycle regulation dynamics and compare checkpoint behavior across conditions.",
  "schema_version": "2.0"
}