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Wolf2000 - Wolf Passarge Somsen Snoepheinrich Westerhoff 2 Lab

About lab

Source-faithful physiology lab for Wolf, Passarge, Somsen, Snoep, Heinrich, Westerhoff, 2000. Public controls and outputs are mapped to real source symbols for glucose-insulin physiology.

Runtime

Duration0.01
Comms Step0.01
Settle Steps1

Runs

Total0
Completed0
Failed0

Metadata

Packagewolf2000-wolf-passarge-somsen-snoepheinrich-westerhoff-2-lab
Created2026-05-23
Updated2026-05-23
physiologycellmlphysiomefaithfulvisualisationother

Manifest

{
  "io": {
    "inputs": [
      {
        "name": "initial_atp",
        "label": "Initial ATP",
        "maps_to": "physiology_cellml_wolf_passarge_somsen_snoep_heinrich_westerhoff_2_wolfpassargesomsensnoepheinrichwesterhoff2000_model.initial_atp",
        "description": "Initial value for ATP. Maps to source symbol `A3`. Units: millimolar. Naming evidence: source metadata names `A3` as `ATP`.",
        "accepted_units": [
          "millimolar"
        ]
      },
      {
        "name": "initial_extracellular_acetaldehyde",
        "label": "Initial Extracellular Acetaldehyde",
        "maps_to": "physiology_cellml_wolf_passarge_somsen_snoep_heinrich_westerhoff_2_wolfpassargesomsensnoepheinrichwesterhoff2000_model.initial_extracellular_acetaldehyde",
        "description": "Initial value for Extracellular Acetaldehyde. Maps to source symbol `S6_ex`. Units: millimolar. Naming evidence: source metadata names `S6_ex` as `extracellular acetaldehyde`.",
        "accepted_units": [
          "millimolar"
        ]
      }
    ],
    "outputs": [
      {
        "name": "state",
        "label": "Selected Source State",
        "maps_to": "physiology_cellml_wolf_passarge_somsen_snoep_heinrich_westerhoff_2_wolfpassargesomsensnoepheinrichwesterhoff2000_model.state"
      },
      {
        "name": "summary",
        "label": "Simulation Summary",
        "maps_to": "physiology_cellml_wolf_passarge_somsen_snoep_heinrich_westerhoff_2_wolfpassargesomsensnoepheinrichwesterhoff2000_model.summary"
      },
      {
        "name": "trajectory",
        "label": "Source Trajectory",
        "maps_to": "physiology_cellml_wolf_passarge_somsen_snoep_heinrich_westerhoff_2_wolfpassargesomsensnoepheinrichwesterhoff2000_model.trajectory"
      },
      {
        "name": "variable_labels",
        "label": "Observable Labels",
        "maps_to": "physiology_cellml_wolf_passarge_somsen_snoep_heinrich_westerhoff_2_wolfpassargesomsensnoepheinrichwesterhoff2000_model.variable_labels"
      },
      {
        "name": "atp",
        "label": "ATP",
        "maps_to": "physiology_cellml_wolf_passarge_somsen_snoep_heinrich_westerhoff_2_wolfpassargesomsensnoepheinrichwesterhoff2000_model.atp",
        "description": "ATP. Maps to source symbol `A3`. Units: millimolar. Naming evidence: source metadata names `A3` as `ATP`."
      },
      {
        "name": "intracellular_potassium",
        "label": "Intracellular Potassium",
        "maps_to": "physiology_cellml_wolf_passarge_somsen_snoep_heinrich_westerhoff_2_wolfpassargesomsensnoepheinrichwesterhoff2000_model.intracellular_potassium",
        "description": "Intracellular Potassium. Maps to source symbol `K_i`. Units: millimolar. Naming evidence: source symbol, component, or units provide a direct public name."
      },
      {
        "name": "s6_flux_rate_across_the_plasma_membrane_j",
        "label": "S6 Flux Rate Across The Plasma Membrane J",
        "maps_to": "physiology_cellml_wolf_passarge_somsen_snoep_heinrich_westerhoff_2_wolfpassargesomsensnoepheinrichwesterhoff2000_model.s6_flux_rate_across_the_plasma_membrane_j",
        "description": "S6 Flux Rate Across The Plasma Membrane J. Maps to source symbol `J`. Units: flux. Naming evidence: source symbol, component, or units provide a direct public name."
      },
      {
        "name": "s6_flux_rate_across_the_plasma_membrane_k",
        "label": "S6 Flux Rate Across The Plasma Membrane K",
        "maps_to": "physiology_cellml_wolf_passarge_somsen_snoep_heinrich_westerhoff_2_wolfpassargesomsensnoepheinrichwesterhoff2000_model.s6_flux_rate_across_the_plasma_membrane_k",
        "description": "S6 Flux Rate Across The Plasma Membrane K. Maps to source symbol `k`. Units: first_order_rate_constant. Naming evidence: source symbol, component, or units provide a direct public name."
      },
      {
        "name": "glucose_influx_rate_jo",
        "label": "Glucose Influx Rate Jo",
        "maps_to": "physiology_cellml_wolf_passarge_somsen_snoep_heinrich_westerhoff_2_wolfpassargesomsensnoepheinrichwesterhoff2000_model.glucose_influx_rate_jo",
        "description": "Glucose Influx Rate Jo. Maps to source symbol `Jo`. Units: flux. Naming evidence: source symbol, component, or units provide a direct public name."
      },
      {
        "name": "nadh",
        "label": "Nadh",
        "maps_to": "physiology_cellml_wolf_passarge_somsen_snoep_heinrich_westerhoff_2_wolfpassargesomsensnoepheinrichwesterhoff2000_model.nadh",
        "description": "Nadh. Maps to source symbol `N2`. Units: millimolar. Naming evidence: source metadata names `N2` as `NADH`."
      }
    ]
  },
  "title": "Wolf2000 - Wolf Passarge Somsen Snoepheinrich Westerhoff 2 Lab",
  "models": [
    {
      "path": "owned/models/physiology_cellml_wolf_passarge_somsen_snoep_heinrich_westerhoff_2_wolfpassargesomsensnoepheinrichwesterhoff2000_model",
      "alias": "physiology_cellml_wolf_passarge_somsen_snoep_heinrich_westerhoff_2_wolfpassargesomsensnoepheinrichwesterhoff2000_model",
      "parameters": {
        "model_path": "data/wolf_passarge_somsen_snoep_heinrich_westerhoff_2000.cellml",
        "integration_step": 0.01
      },
      "provenance": {
        "owned_path": "owned/models/physiology_cellml_wolf_passarge_somsen_snoep_heinrich_westerhoff_2_wolfpassargesomsensnoepheinrichwesterhoff2000_model"
      }
    },
    {
      "path": "owned/models/visualisation",
      "alias": "visualisation",
      "provenance": {
        "owned_path": "owned/models/visualisation"
      }
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.physiology_cellml_wolf_passarge_somsen_snoep_heinrich_westerhoff_2_wolfpassargesomsensnoepheinrichwesterhoff2000_model_state"
      ],
      "from": "physiology_cellml_wolf_passarge_somsen_snoep_heinrich_westerhoff_2_wolfpassargesomsensnoepheinrichwesterhoff2000_model.state"
    },
    {
      "to": [
        "visualisation.physiology_cellml_wolf_passarge_somsen_snoep_heinrich_westerhoff_2_wolfpassargesomsensnoepheinrichwesterhoff2000_model_summary"
      ],
      "from": "physiology_cellml_wolf_passarge_somsen_snoep_heinrich_westerhoff_2_wolfpassargesomsensnoepheinrichwesterhoff2000_model.summary"
    },
    {
      "to": [
        "visualisation.physiology_cellml_wolf_passarge_somsen_snoep_heinrich_westerhoff_2_wolfpassargesomsensnoepheinrichwesterhoff2000_model_trajectory"
      ],
      "from": "physiology_cellml_wolf_passarge_somsen_snoep_heinrich_westerhoff_2_wolfpassargesomsensnoepheinrichwesterhoff2000_model.trajectory"
    },
    {
      "to": [
        "visualisation.physiology_cellml_wolf_passarge_somsen_snoep_heinrich_westerhoff_2_wolfpassargesomsensnoepheinrichwesterhoff2000_model_variable_labels"
      ],
      "from": "physiology_cellml_wolf_passarge_somsen_snoep_heinrich_westerhoff_2_wolfpassargesomsensnoepheinrichwesterhoff2000_model.variable_labels"
    }
  ],
  "runtime": {
    "duration": 0.01,
    "settle_steps": 1,
    "initial_inputs": {},
    "communication_step": 0.01
  },
  "description": "Source-faithful physiology lab for Wolf, Passarge, Somsen, Snoep, Heinrich, Westerhoff, 2000. Public controls and outputs are mapped to real source symbols for glucose-insulin physiology.",
  "schema_version": "2.0"
}

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