Vilar2006 Tgfbeta Lab

{
  "io": {
    "inputs": [
      {
        "name": "initial_ligand_receptor_complex_endosome",
        "label": "Initial Ligand Receptor Complex Endosome",
        "maps_to": "systemsbiology_sbml_vilar2006_tgfbeta_biomd0000000101_model.initial_ligand_receptor_complex_endosome",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `lRIRII_endo`."
      },
      {
        "name": "initial_receptor_2",
        "label": "Initial Receptor 2",
        "maps_to": "systemsbiology_sbml_vilar2006_tgfbeta_biomd0000000101_model.initial_receptor_2",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `RII`."
      },
      {
        "name": "initial_receptor_1",
        "label": "Initial Receptor 1",
        "maps_to": "systemsbiology_sbml_vilar2006_tgfbeta_biomd0000000101_model.initial_receptor_1",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `RI`."
      },
      {
        "name": "initial_ligand_receptor_complex_plasma_membrane",
        "label": "Initial Ligand Receptor Complex Plasma Membrane",
        "maps_to": "systemsbiology_sbml_vilar2006_tgfbeta_biomd0000000101_model.initial_ligand_receptor_complex_plasma_membrane",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `lRIRII`."
      },
      {
        "name": "initial_receptor_2_endosome",
        "label": "Initial Receptor 2 Endosome",
        "maps_to": "systemsbiology_sbml_vilar2006_tgfbeta_biomd0000000101_model.initial_receptor_2_endosome",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `RII_endo`."
      },
      {
        "name": "initial_receptor_1_endosome",
        "label": "Initial Receptor 1 Endosome",
        "maps_to": "systemsbiology_sbml_vilar2006_tgfbeta_biomd0000000101_model.initial_receptor_1_endosome",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `RI_endo`."
      }
    ],
    "outputs": [
      {
        "name": "state",
        "maps_to": "systemsbiology_sbml_vilar2006_tgfbeta_biomd0000000101_model.state"
      },
      {
        "name": "summary",
        "maps_to": "systemsbiology_sbml_vilar2006_tgfbeta_biomd0000000101_model.summary"
      },
      {
        "name": "species_labels",
        "maps_to": "systemsbiology_sbml_vilar2006_tgfbeta_biomd0000000101_model.species_labels"
      },
      {
        "name": "ligand_receptor_complex_endosome",
        "maps_to": "systemsbiology_sbml_vilar2006_tgfbeta_biomd0000000101_model.ligand_receptor_complex_endosome"
      },
      {
        "name": "receptor_2",
        "maps_to": "systemsbiology_sbml_vilar2006_tgfbeta_biomd0000000101_model.receptor_2"
      },
      {
        "name": "receptor_1",
        "maps_to": "systemsbiology_sbml_vilar2006_tgfbeta_biomd0000000101_model.receptor_1"
      },
      {
        "name": "ligand_receptor_complex_plasma_membrane",
        "maps_to": "systemsbiology_sbml_vilar2006_tgfbeta_biomd0000000101_model.ligand_receptor_complex_plasma_membrane"
      },
      {
        "name": "receptor_2_endosome",
        "maps_to": "systemsbiology_sbml_vilar2006_tgfbeta_biomd0000000101_model.receptor_2_endosome"
      },
      {
        "name": "receptor_1_endosome",
        "maps_to": "systemsbiology_sbml_vilar2006_tgfbeta_biomd0000000101_model.receptor_1_endosome"
      }
    ]
  },
  "tags": [
    "signaling",
    "systemsbiology",
    "sbml",
    "biomodels_ebi",
    "faithful",
    "curated"
  ],
  "title": "Vilar2006 Tgfbeta Lab",
  "models": [
    {
      "path": "models/core",
      "alias": "systemsbiology_sbml_vilar2006_tgfbeta_biomd0000000101_model"
    },
    {
      "path": "models/visualisation",
      "alias": "visualisation"
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.systemsbiology_sbml_vilar2006_tgfbeta_biomd0000000101_model_state"
      ],
      "from": "systemsbiology_sbml_vilar2006_tgfbeta_biomd0000000101_model.state"
    },
    {
      "to": [
        "visualisation.systemsbiology_sbml_vilar2006_tgfbeta_biomd0000000101_model_summary"
      ],
      "from": "systemsbiology_sbml_vilar2006_tgfbeta_biomd0000000101_model.summary"
    },
    {
      "to": [
        "visualisation.systemsbiology_sbml_vilar2006_tgfbeta_biomd0000000101_model_species_labels"
      ],
      "from": "systemsbiology_sbml_vilar2006_tgfbeta_biomd0000000101_model.species_labels"
    }
  ],
  "package": "vilar2006-tgfbeta",
  "runtime": {
    "duration": 1,
    "initial_inputs": {},
    "communication_step": 0.1
  },
  "version": "1.0.0",
  "description": "The model reproduces Fig 5A of the paper. The ligand concentration is increased from 3E-5 to 0.01 at time t=2500 to ensure that the system reaches steady state.",
  "schema_version": "2.0"
}