About lab
Dwivedi2014 - Healthy Volunteer IL6 Model Lab
Curated immunology lab using the bundled source model as the scientific source of truth.
What You'll See
This captured run documents the default Dwivedi2014 - Healthy Volunteer IL6 Model configuration for 10.0 time units with a 1.0 communication step. Default inputs include Initial Interleukin 6, Initial Unresolved Immune Observable 1, Initial Soluble Interleukin 6 Sgp130 Complex, and Initial Reactive Protein. Reported outputs include interleukin_6, unresolved_immune_observable_1, soluble_interleukin_6_sgp130_complex, and reactive_protein. The screenshots below pair the run-interpretation table with Immune-cell dynamics and Largest state excursions so the README shows both trajectories and the strongest state changes from the same dark-mode run.
Output Visualizations
The run-interpretation table summarizes the configured Dwivedi2014 - Healthy Volunteer IL6 Model simulation and its final-state diagnostics.
The Immune-cell dynamics time series follows the selected immune, pathogen, tumor, or signaling quantities across the simulated horizon.
The largest state excursions chart ranks the state variables that moved furthest during the run.
Dwivedi2014 - Healthy Volunteer IL6Model This model is comprised of four models: [BIOMD0000000534] Healthy Volunteer model [BIOMD0000000535] Crohn's Disease - IL-6 Antibody [BIOMD0000000536] Crohn's D. It can be used to explore immune response dynamics and compare pathway-level behavior across conditions.
Runtime
Runs
Metadata
Manifest
{
"io": {
"inputs": [
{
"name": "initial_interleukin_6",
"label": "Initial Interleukin 6",
"units": "native source value",
"default": 0.0000482830639918582,
"maps_to": "immunology_sbml_dwivedi2014_healthy_volunteer_il6_model_biomd0000000534_model.initial_interleukin_6",
"description": "Initial Interleukin 6. Sets the initial value of bundled SBML species `mwf626e95e_543f_41e4_aad4_c6bf60ab345b`."
},
{
"name": "initial_unresolved_immune_observable_1",
"label": "Initial Unresolved Immune Observable 1",
"units": "native source value",
"default": 3.9,
"maps_to": "immunology_sbml_dwivedi2014_healthy_volunteer_il6_model_biomd0000000534_model.initial_unresolved_immune_observable_1",
"description": "Initial Unresolved Immune Observable 1. Sets the initial value of bundled SBML species `mwbbbce920_e8dd_4320_9386_fc94bfb2fc99`."
},
{
"name": "initial_soluble_interleukin_6_sgp130_complex",
"label": "Initial Soluble Interleukin 6 Sgp130 Complex",
"units": "native source value",
"default": 0.00158509246200931,
"maps_to": "immunology_sbml_dwivedi2014_healthy_volunteer_il6_model_biomd0000000534_model.initial_soluble_interleukin_6_sgp130_complex",
"description": "Initial Soluble Interleukin 6 Sgp130 Complex. Sets the initial value of bundled SBML species `mw810ff751_fa4e_4143_bd50_169b3e325e1e`."
},
{
"name": "initial_reactive_protein",
"label": "Initial Reactive Protein",
"units": "native source value",
"default": 40.196036452179,
"maps_to": "immunology_sbml_dwivedi2014_healthy_volunteer_il6_model_biomd0000000534_model.initial_reactive_protein",
"description": "Initial Reactive Protein. Sets the initial value of bundled SBML species `mw114aa90f_5f5b_4fe8_9406_361c8489b6a1`."
},
{
"name": "initial_unresolved_immune_observable_2",
"label": "Initial Unresolved Immune Observable 2",
"units": "native source value",
"default": 1.05563779110703,
"maps_to": "immunology_sbml_dwivedi2014_healthy_volunteer_il6_model_biomd0000000534_model.initial_unresolved_immune_observable_2",
"description": "Initial Unresolved Immune Observable 2. Sets the initial value of bundled SBML species `mw30ae63db_6cd3_4b6f_93ad_3350cd360bcc`."
},
{
"name": "dose",
"label": "Dose",
"units": "native source value",
"default": 100,
"maps_to": "immunology_sbml_dwivedi2014_healthy_volunteer_il6_model_biomd0000000534_model.dose",
"description": "Dose. Sets bundled SBML parameter `parameter_1`."
},
{
"name": "dose_initial_parameter",
"label": "Dose Initial Parameter",
"units": "native source value",
"default": 100,
"maps_to": "immunology_sbml_dwivedi2014_healthy_volunteer_il6_model_biomd0000000534_model.dose_initial_parameter",
"description": "Dose Initial Parameter. Sets bundled SBML parameter `ModelValue_48`."
}
],
"outputs": [
{
"name": "interleukin_6",
"maps_to": "immunology_sbml_dwivedi2014_healthy_volunteer_il6_model_biomd0000000534_model.interleukin_6"
},
{
"name": "unresolved_immune_observable_1",
"maps_to": "immunology_sbml_dwivedi2014_healthy_volunteer_il6_model_biomd0000000534_model.unresolved_immune_observable_1"
},
{
"name": "soluble_interleukin_6_sgp130_complex",
"maps_to": "immunology_sbml_dwivedi2014_healthy_volunteer_il6_model_biomd0000000534_model.soluble_interleukin_6_sgp130_complex"
},
{
"name": "reactive_protein",
"maps_to": "immunology_sbml_dwivedi2014_healthy_volunteer_il6_model_biomd0000000534_model.reactive_protein"
},
{
"name": "unresolved_immune_observable_2",
"maps_to": "immunology_sbml_dwivedi2014_healthy_volunteer_il6_model_biomd0000000534_model.unresolved_immune_observable_2"
},
{
"name": "state",
"maps_to": "immunology_sbml_dwivedi2014_healthy_volunteer_il6_model_biomd0000000534_model.state"
},
{
"name": "summary",
"maps_to": "immunology_sbml_dwivedi2014_healthy_volunteer_il6_model_biomd0000000534_model.summary"
},
{
"name": "species_labels",
"maps_to": "immunology_sbml_dwivedi2014_healthy_volunteer_il6_model_biomd0000000534_model.species_labels"
}
]
},
"title": "Dwivedi2014 - Healthy Volunteer IL6 Model Lab",
"models": [
{
"path": "owned/models/immunology_sbml_dwivedi2014_healthy_volunteer_il6_model_biomd0000000534_model",
"alias": "immunology_sbml_dwivedi2014_healthy_volunteer_il6_model_biomd0000000534_model",
"provenance": {
"owned_path": "owned/models/immunology_sbml_dwivedi2014_healthy_volunteer_il6_model_biomd0000000534_model"
}
},
{
"path": "owned/models/visualisation",
"alias": "visualisation",
"provenance": {
"owned_path": "owned/models/visualisation"
}
}
],
"wiring": [
{
"to": [
"visualisation.immunology_sbml_dwivedi2014_healthy_volunteer_il6_model_biomd0000000534_model_state"
],
"from": "immunology_sbml_dwivedi2014_healthy_volunteer_il6_model_biomd0000000534_model.state"
},
{
"to": [
"visualisation.immunology_sbml_dwivedi2014_healthy_volunteer_il6_model_biomd0000000534_model_summary"
],
"from": "immunology_sbml_dwivedi2014_healthy_volunteer_il6_model_biomd0000000534_model.summary"
},
{
"to": [
"visualisation.immunology_sbml_dwivedi2014_healthy_volunteer_il6_model_biomd0000000534_model_species_labels"
],
"from": "immunology_sbml_dwivedi2014_healthy_volunteer_il6_model_biomd0000000534_model.species_labels"
}
],
"runtime": {
"duration": 10,
"initial_inputs": {},
"communication_step": 1
},
"description": "Dwivedi2014 - Healthy Volunteer IL6Model This model is comprised of four models: [BIOMD0000000534] Healthy Volunteer model [BIOMD0000000535] Crohn's Disease - IL-6 Antibody [BIOMD0000000536] Crohn's D. It can be used to explore immune response dynamics and compare pathway-level behavior across conditions.",
"schema_version": "2.0"
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