About lab
Dwivedi2014 - Healthy Volunteer IL6Model This model is comprised of four models: [BIOMD0000000534] Healthy Volunteer model [BIOMD0000000535] Crohn's Disease - IL-6 Antibody [BIOMD0000000536] Crohn's D. It can be used to explore immune response dynamics and compare pathway-level behavior across conditions.
Runtime
Duration10
Comms Step1
Runs
Total0
Completed0
Failed0
Metadata
Packagedwivedi2014-healthy-volunteer-il6-model
Created2026-05-15
Updated2026-06-13
immunologysbmlbiomodels_ebifaithfulcuratedvisualisationother
Manifest
{
"io": {
"inputs": [
{
"name": "initial_interleukin_6",
"label": "Initial Interleukin 6",
"units": "native source value",
"default": 0.0000482830639918582,
"maps_to": "immunology_sbml_dwivedi2014_healthy_volunteer_il6_model_biomd0000000534_model.initial_interleukin_6",
"description": "Initial Interleukin 6. Sets the initial value of bundled SBML species `mwf626e95e_543f_41e4_aad4_c6bf60ab345b`."
},
{
"name": "initial_unresolved_immune_observable_1",
"label": "Initial Unresolved Immune Observable 1",
"units": "native source value",
"default": 3.9,
"maps_to": "immunology_sbml_dwivedi2014_healthy_volunteer_il6_model_biomd0000000534_model.initial_unresolved_immune_observable_1",
"description": "Initial Unresolved Immune Observable 1. Sets the initial value of bundled SBML species `mwbbbce920_e8dd_4320_9386_fc94bfb2fc99`."
},
{
"name": "initial_soluble_interleukin_6_sgp130_complex",
"label": "Initial Soluble Interleukin 6 Sgp130 Complex",
"units": "native source value",
"default": 0.00158509246200931,
"maps_to": "immunology_sbml_dwivedi2014_healthy_volunteer_il6_model_biomd0000000534_model.initial_soluble_interleukin_6_sgp130_complex",
"description": "Initial Soluble Interleukin 6 Sgp130 Complex. Sets the initial value of bundled SBML species `mw810ff751_fa4e_4143_bd50_169b3e325e1e`."
},
{
"name": "initial_reactive_protein",
"label": "Initial Reactive Protein",
"units": "native source value",
"default": 40.196036452179,
"maps_to": "immunology_sbml_dwivedi2014_healthy_volunteer_il6_model_biomd0000000534_model.initial_reactive_protein",
"description": "Initial Reactive Protein. Sets the initial value of bundled SBML species `mw114aa90f_5f5b_4fe8_9406_361c8489b6a1`."
},
{
"name": "initial_unresolved_immune_observable_2",
"label": "Initial Unresolved Immune Observable 2",
"units": "native source value",
"default": 1.05563779110703,
"maps_to": "immunology_sbml_dwivedi2014_healthy_volunteer_il6_model_biomd0000000534_model.initial_unresolved_immune_observable_2",
"description": "Initial Unresolved Immune Observable 2. Sets the initial value of bundled SBML species `mw30ae63db_6cd3_4b6f_93ad_3350cd360bcc`."
},
{
"name": "dose",
"label": "Dose",
"units": "native source value",
"default": 100,
"maps_to": "immunology_sbml_dwivedi2014_healthy_volunteer_il6_model_biomd0000000534_model.dose",
"description": "Dose. Sets bundled SBML parameter `parameter_1`."
},
{
"name": "dose_initial_parameter",
"label": "Dose Initial Parameter",
"units": "native source value",
"default": 100,
"maps_to": "immunology_sbml_dwivedi2014_healthy_volunteer_il6_model_biomd0000000534_model.dose_initial_parameter",
"description": "Dose Initial Parameter. Sets bundled SBML parameter `ModelValue_48`."
}
],
"outputs": [
{
"name": "interleukin_6",
"maps_to": "immunology_sbml_dwivedi2014_healthy_volunteer_il6_model_biomd0000000534_model.interleukin_6"
},
{
"name": "unresolved_immune_observable_1",
"maps_to": "immunology_sbml_dwivedi2014_healthy_volunteer_il6_model_biomd0000000534_model.unresolved_immune_observable_1"
},
{
"name": "soluble_interleukin_6_sgp130_complex",
"maps_to": "immunology_sbml_dwivedi2014_healthy_volunteer_il6_model_biomd0000000534_model.soluble_interleukin_6_sgp130_complex"
},
{
"name": "reactive_protein",
"maps_to": "immunology_sbml_dwivedi2014_healthy_volunteer_il6_model_biomd0000000534_model.reactive_protein"
},
{
"name": "unresolved_immune_observable_2",
"maps_to": "immunology_sbml_dwivedi2014_healthy_volunteer_il6_model_biomd0000000534_model.unresolved_immune_observable_2"
},
{
"name": "state",
"maps_to": "immunology_sbml_dwivedi2014_healthy_volunteer_il6_model_biomd0000000534_model.state"
},
{
"name": "summary",
"maps_to": "immunology_sbml_dwivedi2014_healthy_volunteer_il6_model_biomd0000000534_model.summary"
},
{
"name": "species_labels",
"maps_to": "immunology_sbml_dwivedi2014_healthy_volunteer_il6_model_biomd0000000534_model.species_labels"
}
]
},
"title": "Dwivedi2014 - Healthy Volunteer IL6 Model Lab",
"models": [
{
"path": "models/core",
"alias": "immunology_sbml_dwivedi2014_healthy_volunteer_il6_model_biomd0000000534_model"
},
{
"path": "models/visualisation",
"alias": "visualisation"
}
],
"wiring": [
{
"to": [
"visualisation.immunology_sbml_dwivedi2014_healthy_volunteer_il6_model_biomd0000000534_model_state"
],
"from": "immunology_sbml_dwivedi2014_healthy_volunteer_il6_model_biomd0000000534_model.state"
},
{
"to": [
"visualisation.immunology_sbml_dwivedi2014_healthy_volunteer_il6_model_biomd0000000534_model_summary"
],
"from": "immunology_sbml_dwivedi2014_healthy_volunteer_il6_model_biomd0000000534_model.summary"
},
{
"to": [
"visualisation.immunology_sbml_dwivedi2014_healthy_volunteer_il6_model_biomd0000000534_model_species_labels"
],
"from": "immunology_sbml_dwivedi2014_healthy_volunteer_il6_model_biomd0000000534_model.species_labels"
}
],
"package": "dwivedi2014-healthy-volunteer-il6-model",
"runtime": {
"duration": 10,
"initial_inputs": {},
"communication_step": 1
},
"version": "1.0.0",
"description": "Dwivedi2014 - Healthy Volunteer IL6Model This model is comprised of four models: [BIOMD0000000534] Healthy Volunteer model [BIOMD0000000535] Crohn's Disease - IL-6 Antibody [BIOMD0000000536] Crohn's D. It can be used to explore immune response dynamics and compare pathway-level behavior across conditions.",
"schema_version": "2.0"
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