Leon-Triana2021 - Competition between tumour cells and dual-target CAR T-cells Lab

{
  "io": {
    "inputs": [
      {
        "name": "initial_car_t_cells_on_tumour",
        "label": "Initial Car T Cells On Tumour",
        "units": "native source value",
        "default": 0,
        "maps_to": "immunology_sbml_leon_triana2021_competition_between_tumour_cells_biomd0000001014_model.initial_car_t_cells_on_tumour",
        "description": "Initial Car T Cells On Tumour. Sets the initial value of bundled SBML species `CAR_T_cells_on_tumour`."
      },
      {
        "name": "initial_car_t_cells_off_tumour",
        "label": "Initial Car T Cells Off Tumour",
        "units": "native source value",
        "default": 200000000,
        "maps_to": "immunology_sbml_leon_triana2021_competition_between_tumour_cells_biomd0000001014_model.initial_car_t_cells_off_tumour",
        "description": "Initial Car T Cells Off Tumour. Sets the initial value of bundled SBML species `CAR_T_cells_off_tumour`."
      },
      {
        "name": "initial_tumour_cells",
        "label": "Initial Tumour Cells",
        "units": "native source value",
        "default": 33500000000,
        "maps_to": "immunology_sbml_leon_triana2021_competition_between_tumour_cells_biomd0000001014_model.initial_tumour_cells",
        "description": "Initial Tumour Cells. Sets the initial value of bundled SBML species `Tumour_cells`."
      },
      {
        "name": "initial_cells",
        "label": "Initial Cells",
        "units": "native source value",
        "default": 25000000000,
        "maps_to": "immunology_sbml_leon_triana2021_competition_between_tumour_cells_biomd0000001014_model.initial_cells",
        "description": "Initial Cells. Sets the initial value of bundled SBML species `B_cells`."
      },
      {
        "name": "tumour_death_rate",
        "label": "Tumour Death Rate",
        "units": "unit_3",
        "default": 2.5e-10,
        "maps_to": "immunology_sbml_leon_triana2021_competition_between_tumour_cells_biomd0000001014_model.tumour_death_rate",
        "description": "Tumour Death Rate. Sets bundled SBML parameter `alpha_2`."
      }
    ],
    "outputs": [
      {
        "name": "car_t_cells_on_tumour",
        "maps_to": "immunology_sbml_leon_triana2021_competition_between_tumour_cells_biomd0000001014_model.car_t_cells_on_tumour"
      },
      {
        "name": "car_t_cells_off_tumour",
        "maps_to": "immunology_sbml_leon_triana2021_competition_between_tumour_cells_biomd0000001014_model.car_t_cells_off_tumour"
      },
      {
        "name": "car_t_cells_total",
        "maps_to": "immunology_sbml_leon_triana2021_competition_between_tumour_cells_biomd0000001014_model.car_t_cells_total"
      },
      {
        "name": "tumour_cells",
        "maps_to": "immunology_sbml_leon_triana2021_competition_between_tumour_cells_biomd0000001014_model.tumour_cells"
      },
      {
        "name": "cells",
        "maps_to": "immunology_sbml_leon_triana2021_competition_between_tumour_cells_biomd0000001014_model.cells"
      },
      {
        "name": "state",
        "maps_to": "immunology_sbml_leon_triana2021_competition_between_tumour_cells_biomd0000001014_model.state"
      },
      {
        "name": "summary",
        "maps_to": "immunology_sbml_leon_triana2021_competition_between_tumour_cells_biomd0000001014_model.summary"
      },
      {
        "name": "species_labels",
        "maps_to": "immunology_sbml_leon_triana2021_competition_between_tumour_cells_biomd0000001014_model.species_labels"
      }
    ]
  },
  "title": "Leon-Triana2021 - Competition between tumour cells and dual-target CAR T-cells Lab",
  "models": [
    {
      "path": "owned/models/immunology_sbml_leon_triana2021_competition_between_tumour_cells_biomd0000001014_model",
      "alias": "immunology_sbml_leon_triana2021_competition_between_tumour_cells_biomd0000001014_model",
      "provenance": {
        "owned_path": "owned/models/immunology_sbml_leon_triana2021_competition_between_tumour_cells_biomd0000001014_model"
      }
    },
    {
      "path": "owned/models/visualisation",
      "alias": "visualisation",
      "provenance": {
        "owned_path": "owned/models/visualisation"
      }
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.immunology_sbml_leon_triana2021_competition_between_tumour_cells_biomd0000001014_model_state"
      ],
      "from": "immunology_sbml_leon_triana2021_competition_between_tumour_cells_biomd0000001014_model.state"
    },
    {
      "to": [
        "visualisation.immunology_sbml_leon_triana2021_competition_between_tumour_cells_biomd0000001014_model_summary"
      ],
      "from": "immunology_sbml_leon_triana2021_competition_between_tumour_cells_biomd0000001014_model.summary"
    },
    {
      "to": [
        "visualisation.immunology_sbml_leon_triana2021_competition_between_tumour_cells_biomd0000001014_model_species_labels"
      ],
      "from": "immunology_sbml_leon_triana2021_competition_between_tumour_cells_biomd0000001014_model.species_labels"
    }
  ],
  "runtime": {
    "duration": 10,
    "initial_inputs": {},
    "communication_step": 1
  },
  "description": "This model of the use of chimeric antigen receptor (CAR)-T cell therapy in the treatment of solid tumours is described in the article:'Dual-Target CAR-Ts with On- and Off-Tumour Activity May Override. It can be used to explore immune response dynamics and compare pathway-level behavior across conditions.",
  "schema_version": "2.0"
}