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Aguda1999 Cellcycle Lab

About lab

The model reproduces the time profiles of p27, E2F and aE/cdk2 as depicted in Figure 5 c of the paper. It can be used to explore systemsbiology aguda1999 cellcycle BioModels0000000169 dynamics and compare simulation behavior across conditions.

Runtime

Duration1
Comms Step0.1

Runs

Total0
Completed0
Failed0

Metadata

Packageaguda1999-cellcycle-lab
Created2026-05-17
Updated2026-05-17
cellcyclesystemsbiologysbmlbiomodels_ebifaithfulcuratedvisualisation

Manifest

{
  "io": {
    "inputs": [
      {
        "name": "initial_model_state_p27",
        "label": "Initial Model State P27",
        "maps_to": "systemsbiology_sbml_aguda1999_cellcycle_biomd0000000169_model.initial_model_state_p27",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `Y7_1`."
      },
      {
        "name": "initial_model_state_p16",
        "label": "Initial Model State P16",
        "maps_to": "systemsbiology_sbml_aguda1999_cellcycle_biomd0000000169_model.initial_model_state_p16",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `Y10_1`."
      },
      {
        "name": "initial_p_rb_e2_f",
        "label": "Initial P Rb E2 F",
        "maps_to": "systemsbiology_sbml_aguda1999_cellcycle_biomd0000000169_model.initial_p_rb_e2_f",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `Y3_1`."
      },
      {
        "name": "initial_cyc_e_cdk2_p27",
        "label": "Initial Cyc E Cdk2 P27",
        "maps_to": "systemsbiology_sbml_aguda1999_cellcycle_biomd0000000169_model.initial_cyc_e_cdk2_p27",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `Y8_1`."
      },
      {
        "name": "initial_p_rb",
        "label": "Initial P Rb",
        "maps_to": "systemsbiology_sbml_aguda1999_cellcycle_biomd0000000169_model.initial_p_rb",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `Y5_1`."
      },
      {
        "name": "initial_p_rb_p",
        "label": "Initial P Rb P",
        "maps_to": "systemsbiology_sbml_aguda1999_cellcycle_biomd0000000169_model.initial_p_rb_p",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `Y11_1`."
      }
    ],
    "outputs": [
      {
        "name": "state",
        "maps_to": "systemsbiology_sbml_aguda1999_cellcycle_biomd0000000169_model.state"
      },
      {
        "name": "summary",
        "maps_to": "systemsbiology_sbml_aguda1999_cellcycle_biomd0000000169_model.summary"
      },
      {
        "name": "species_labels",
        "maps_to": "systemsbiology_sbml_aguda1999_cellcycle_biomd0000000169_model.species_labels"
      },
      {
        "name": "p27",
        "maps_to": "systemsbiology_sbml_aguda1999_cellcycle_biomd0000000169_model.p27"
      },
      {
        "name": "p16",
        "maps_to": "systemsbiology_sbml_aguda1999_cellcycle_biomd0000000169_model.p16"
      },
      {
        "name": "p_rb_e2_f",
        "maps_to": "systemsbiology_sbml_aguda1999_cellcycle_biomd0000000169_model.p_rb_e2_f"
      },
      {
        "name": "cyc_e_cdk2_p27",
        "maps_to": "systemsbiology_sbml_aguda1999_cellcycle_biomd0000000169_model.cyc_e_cdk2_p27"
      },
      {
        "name": "p_rb",
        "maps_to": "systemsbiology_sbml_aguda1999_cellcycle_biomd0000000169_model.p_rb"
      },
      {
        "name": "p_rb_p",
        "maps_to": "systemsbiology_sbml_aguda1999_cellcycle_biomd0000000169_model.p_rb_p"
      }
    ]
  },
  "tags": [
    "cellcycle",
    "systemsbiology",
    "sbml",
    "biomodels_ebi",
    "faithful",
    "curated"
  ],
  "title": "Aguda1999 Cellcycle Lab",
  "models": [
    {
      "path": "owned/models/systemsbiology_sbml_aguda1999_cellcycle_biomd0000000169_model",
      "alias": "systemsbiology_sbml_aguda1999_cellcycle_biomd0000000169_model",
      "provenance": {
        "owned_path": "owned/models/systemsbiology_sbml_aguda1999_cellcycle_biomd0000000169_model"
      }
    },
    {
      "path": "owned/models/visualisation",
      "alias": "visualisation",
      "provenance": {
        "owned_path": "owned/models/visualisation"
      }
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.systemsbiology_sbml_aguda1999_cellcycle_biomd0000000169_model_state"
      ],
      "from": "systemsbiology_sbml_aguda1999_cellcycle_biomd0000000169_model.state"
    },
    {
      "to": [
        "visualisation.systemsbiology_sbml_aguda1999_cellcycle_biomd0000000169_model_summary"
      ],
      "from": "systemsbiology_sbml_aguda1999_cellcycle_biomd0000000169_model.summary"
    },
    {
      "to": [
        "visualisation.systemsbiology_sbml_aguda1999_cellcycle_biomd0000000169_model_species_labels"
      ],
      "from": "systemsbiology_sbml_aguda1999_cellcycle_biomd0000000169_model.species_labels"
    }
  ],
  "runtime": {
    "duration": 1,
    "initial_inputs": {},
    "communication_step": 0.1
  },
  "description": "The model reproduces the time profiles of p27, E2F and aE/cdk2 as depicted in Figure 5 c of the paper. It can be used to explore systemsbiology aguda1999 cellcycle BioModels0000000169 dynamics and compare simulation behavior across conditions.",
  "schema_version": "2.0"
}

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