Yu2019 - A mathematical model of tumor-immune interactions with an immune checkpoint inhibitor Lab

{
  "io": {
    "inputs": [
      {
        "name": "initial_unresolved_tumor_observable_1",
        "label": "Initial Unresolved Tumor Observable 1",
        "units": "native source value",
        "default": 250000,
        "maps_to": "immunology_sbml_yu2019_a_mathematical_model_of_tumor_immune_inte_model1911270002_model.initial_unresolved_tumor_observable_1",
        "description": "Initial Unresolved Tumor Observable 1. Sets the initial value of bundled SBML species `x`."
      },
      {
        "name": "initial_unresolved_tumor_observable_2",
        "label": "Initial Unresolved Tumor Observable 2",
        "units": "native source value",
        "default": 0,
        "maps_to": "immunology_sbml_yu2019_a_mathematical_model_of_tumor_immune_inte_model1911270002_model.initial_unresolved_tumor_observable_2",
        "description": "Initial Unresolved Tumor Observable 2. Sets the initial value of bundled SBML species `y`."
      },
      {
        "name": "initial_unresolved_tumor_observable_3",
        "label": "Initial Unresolved Tumor Observable 3",
        "units": "native source value",
        "default": 0,
        "maps_to": "immunology_sbml_yu2019_a_mathematical_model_of_tumor_immune_inte_model1911270002_model.initial_unresolved_tumor_observable_3",
        "description": "Initial Unresolved Tumor Observable 3. Sets the initial value of bundled SBML species `z`."
      },
      {
        "name": "initial_unresolved_tumor_observable_4",
        "label": "Initial Unresolved Tumor Observable 4",
        "units": "native source value",
        "default": 0,
        "maps_to": "immunology_sbml_yu2019_a_mathematical_model_of_tumor_immune_inte_model1911270002_model.initial_unresolved_tumor_observable_4",
        "description": "Initial Unresolved Tumor Observable 4. Sets the initial value of bundled SBML species `w`."
      },
      {
        "name": "tumor_growth_rate",
        "label": "Tumor Growth Rate",
        "units": "native source value",
        "default": 0.514,
        "maps_to": "immunology_sbml_yu2019_a_mathematical_model_of_tumor_immune_inte_model1911270002_model.tumor_growth_rate",
        "description": "Tumor Growth Rate. Sets bundled SBML parameter `r`."
      },
      {
        "name": "tumor_death_cytokines_rate",
        "label": "Tumor Death Cytokines Rate",
        "units": "native source value",
        "default": 0.2,
        "maps_to": "immunology_sbml_yu2019_a_mathematical_model_of_tumor_immune_inte_model1911270002_model.tumor_death_cytokines_rate",
        "description": "Tumor Death Cytokines Rate. Sets bundled SBML parameter `delta`."
      },
      {
        "name": "th_proliferation_rate",
        "label": "Th Proliferation Rate",
        "units": "native source value",
        "default": 0.09,
        "maps_to": "immunology_sbml_yu2019_a_mathematical_model_of_tumor_immune_inte_model1911270002_model.th_proliferation_rate",
        "description": "Th Proliferation Rate. Sets bundled SBML parameter `beta`."
      },
      {
        "name": "interferon_gamma_decay_rate",
        "label": "Interferon Gamma Decay Rate",
        "units": "native source value",
        "default": 34,
        "maps_to": "immunology_sbml_yu2019_a_mathematical_model_of_tumor_immune_inte_model1911270002_model.interferon_gamma_decay_rate",
        "description": "Interferon Gamma Decay Rate. Sets bundled SBML parameter `mu`."
      },
      {
        "name": "ctla_4_decay_rate",
        "label": "Ctla 4 Decay Rate",
        "units": "native source value",
        "default": 8.3178,
        "maps_to": "immunology_sbml_yu2019_a_mathematical_model_of_tumor_immune_inte_model1911270002_model.ctla_4_decay_rate",
        "description": "Ctla 4 Decay Rate. Sets bundled SBML parameter `d`."
      }
    ],
    "outputs": [
      {
        "name": "unresolved_tumor_observable_1",
        "maps_to": "immunology_sbml_yu2019_a_mathematical_model_of_tumor_immune_inte_model1911270002_model.unresolved_tumor_observable_1"
      },
      {
        "name": "unresolved_tumor_observable_2",
        "maps_to": "immunology_sbml_yu2019_a_mathematical_model_of_tumor_immune_inte_model1911270002_model.unresolved_tumor_observable_2"
      },
      {
        "name": "unresolved_tumor_observable_3",
        "maps_to": "immunology_sbml_yu2019_a_mathematical_model_of_tumor_immune_inte_model1911270002_model.unresolved_tumor_observable_3"
      },
      {
        "name": "unresolved_tumor_observable_4",
        "maps_to": "immunology_sbml_yu2019_a_mathematical_model_of_tumor_immune_inte_model1911270002_model.unresolved_tumor_observable_4"
      },
      {
        "name": "state",
        "maps_to": "immunology_sbml_yu2019_a_mathematical_model_of_tumor_immune_inte_model1911270002_model.state"
      },
      {
        "name": "summary",
        "maps_to": "immunology_sbml_yu2019_a_mathematical_model_of_tumor_immune_inte_model1911270002_model.summary"
      },
      {
        "name": "species_labels",
        "maps_to": "immunology_sbml_yu2019_a_mathematical_model_of_tumor_immune_inte_model1911270002_model.species_labels"
      }
    ]
  },
  "title": "Yu2019 - A mathematical model of tumor-immune interactions with an immune checkpoint inhibitor Lab",
  "models": [
    {
      "path": "models/core",
      "alias": "immunology_sbml_yu2019_a_mathematical_model_of_tumor_immune_inte_model1911270002_model"
    },
    {
      "path": "models/visualisation",
      "alias": "visualisation"
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.immunology_sbml_yu2019_a_mathematical_model_of_tumor_immune_inte_model1911270002_model_state"
      ],
      "from": "immunology_sbml_yu2019_a_mathematical_model_of_tumor_immune_inte_model1911270002_model.state"
    },
    {
      "to": [
        "visualisation.immunology_sbml_yu2019_a_mathematical_model_of_tumor_immune_inte_model1911270002_model_summary"
      ],
      "from": "immunology_sbml_yu2019_a_mathematical_model_of_tumor_immune_inte_model1911270002_model.summary"
    },
    {
      "to": [
        "visualisation.immunology_sbml_yu2019_a_mathematical_model_of_tumor_immune_inte_model1911270002_model_species_labels"
      ],
      "from": "immunology_sbml_yu2019_a_mathematical_model_of_tumor_immune_inte_model1911270002_model.species_labels"
    }
  ],
  "package": "yu2019-a-mathematical-model-of-tumor-immune-interactions",
  "runtime": {
    "duration": 10,
    "initial_inputs": {},
    "communication_step": 1
  },
  "version": "1.0.0",
  "description": "This is a mathematical model investigating interactions among malignant tumor cells, CD4+ T cells, anti-tumor cytokines (specifically IFN-gamma), and the immune checkpoint inhibitor CTLA-4 to assess t. It can be used to explore immune response dynamics and compare pathway-level behavior across conditions.",
  "schema_version": "2.0"
}