About lab
Its a mechanistic model explaining the impact of p53 om apoptosis decision. It can be used to explore systemsbiology zhang2007 mechanism of dna damage dynamics and compare simulation behavior across conditions.
Runtime
Duration1
Comms Step0.1
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Completed0
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Metadata
Packagezhang2007-mechanism-of-dna-damage-response-lab
Created2026-05-17
Updated2026-05-17
cellcyclesystemsbiologysbmlbiomodels_ebifaithfulcuratedvisualisation
Manifest
{
"io": {
"inputs": [
{
"name": "initial_dn_adamage",
"label": "Initial Dn Adamage",
"maps_to": "systemsbiology_sbml_zhang2007_mechanism_of_dna_damage_response_model_biomd0000001007_model.initial_dn_adamage",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `DNAdamage`."
},
{
"name": "initial_model_state_p53",
"label": "Initial Model State P53",
"maps_to": "systemsbiology_sbml_zhang2007_mechanism_of_dna_damage_response_model_biomd0000001007_model.initial_model_state_p53",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `p53`."
},
{
"name": "initial_mdm2nuc",
"label": "Initial Mdm2nuc",
"maps_to": "systemsbiology_sbml_zhang2007_mechanism_of_dna_damage_response_model_biomd0000001007_model.initial_mdm2nuc",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `MDM2nuc`."
},
{
"name": "initial_mdm2cyt",
"label": "Initial Mdm2cyt",
"maps_to": "systemsbiology_sbml_zhang2007_mechanism_of_dna_damage_response_model_biomd0000001007_model.initial_mdm2cyt",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `MDM2cyt`."
}
],
"outputs": [
{
"name": "state",
"maps_to": "systemsbiology_sbml_zhang2007_mechanism_of_dna_damage_response_model_biomd0000001007_model.state"
},
{
"name": "summary",
"maps_to": "systemsbiology_sbml_zhang2007_mechanism_of_dna_damage_response_model_biomd0000001007_model.summary"
},
{
"name": "species_labels",
"maps_to": "systemsbiology_sbml_zhang2007_mechanism_of_dna_damage_response_model_biomd0000001007_model.species_labels"
},
{
"name": "dn_adamage",
"maps_to": "systemsbiology_sbml_zhang2007_mechanism_of_dna_damage_response_model_biomd0000001007_model.dn_adamage"
},
{
"name": "p53",
"maps_to": "systemsbiology_sbml_zhang2007_mechanism_of_dna_damage_response_model_biomd0000001007_model.p53"
},
{
"name": "mdm2nuc",
"maps_to": "systemsbiology_sbml_zhang2007_mechanism_of_dna_damage_response_model_biomd0000001007_model.mdm2nuc"
},
{
"name": "mdm2cyt",
"maps_to": "systemsbiology_sbml_zhang2007_mechanism_of_dna_damage_response_model_biomd0000001007_model.mdm2cyt"
}
]
},
"tags": [
"cellcycle",
"systemsbiology",
"sbml",
"biomodels_ebi",
"faithful",
"curated"
],
"title": "Zhang2007 Mechanism Of Dna Damage Response Lab",
"models": [
{
"path": "owned/models/systemsbiology_sbml_zhang2007_mechanism_of_dna_damage_response_model_biomd0000001007_model",
"alias": "systemsbiology_sbml_zhang2007_mechanism_of_dna_damage_response_model_biomd0000001007_model",
"provenance": {
"owned_path": "owned/models/systemsbiology_sbml_zhang2007_mechanism_of_dna_damage_response_model_biomd0000001007_model"
}
},
{
"path": "owned/models/visualisation",
"alias": "visualisation",
"provenance": {
"owned_path": "owned/models/visualisation"
}
}
],
"wiring": [
{
"to": [
"visualisation.systemsbiology_sbml_zhang2007_mechanism_of_dna_damage_response_model_biomd0000001007_model_state"
],
"from": "systemsbiology_sbml_zhang2007_mechanism_of_dna_damage_response_model_biomd0000001007_model.state"
},
{
"to": [
"visualisation.systemsbiology_sbml_zhang2007_mechanism_of_dna_damage_response_model_biomd0000001007_model_summary"
],
"from": "systemsbiology_sbml_zhang2007_mechanism_of_dna_damage_response_model_biomd0000001007_model.summary"
},
{
"to": [
"visualisation.systemsbiology_sbml_zhang2007_mechanism_of_dna_damage_response_model_biomd0000001007_model_species_labels"
],
"from": "systemsbiology_sbml_zhang2007_mechanism_of_dna_damage_response_model_biomd0000001007_model.species_labels"
}
],
"runtime": {
"duration": 1,
"initial_inputs": {},
"communication_step": 0.1
},
"description": "Its a mechanistic model explaining the impact of p53 om apoptosis decision. It can be used to explore systemsbiology zhang2007 mechanism of dna damage dynamics and compare simulation behavior across conditions.",
"schema_version": "2.0"
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