Iyer2007 Arrhythmia Cardiac Death Lab

{
  "io": {
    "inputs": [
      {
        "name": "integration_step",
        "maps_to": "iyer2007_arrhythmia_cardiac_death_core.integration_step"
      },
      {
        "name": "parameter_overrides",
        "maps_to": "iyer2007_arrhythmia_cardiac_death_core.parameter_overrides"
      },
      {
        "name": "initial_conditions",
        "maps_to": "iyer2007_arrhythmia_cardiac_death_core.initial_conditions"
      }
    ],
    "outputs": [
      {
        "name": "scenario_metadata",
        "maps_to": "iyer2007_arrhythmia_cardiac_death_scenario.scenario_metadata"
      },
      {
        "name": "state",
        "maps_to": "iyer2007_arrhythmia_cardiac_death_core.state"
      },
      {
        "name": "run_summary",
        "maps_to": "iyer2007_arrhythmia_cardiac_death_viz.run_summary"
      }
    ]
  },
  "title": "Iyer2007 Arrhythmia Cardiac Death Lab",
  "models": [
    {
      "path": "owned/models/iyer2007_arrhythmia_cardiac_death_scenario",
      "alias": "iyer2007_arrhythmia_cardiac_death_scenario",
      "parameters": {
        "schedule": {
          "temperature": {
            "unit": "dimensionless",
            "label": "temperature",
            "active": false,
            "baseline": 310,
            "recovery": 310,
            "challenge": 310,
            "description": "Scenario-controlled temperature value."
          },
          "isoproterenol_drive": {
            "unit": "dimensionless",
            "label": "isoproterenol drive",
            "active": false,
            "baseline": 0,
            "recovery": 0,
            "challenge": 0,
            "description": "Scenario-controlled isoproterenol drive value."
          },
          "calsequestrin_buffer": {
            "unit": "dimensionless",
            "label": "calsequestrin buffer",
            "active": false,
            "baseline": 0,
            "recovery": 0,
            "challenge": 0,
            "description": "Scenario-controlled calsequestrin buffer value."
          },
          "intracellular_calcium": {
            "unit": "mM",
            "label": "intracellular calcium",
            "active": true,
            "baseline": 0.00036396867218,
            "recovery": 0.00036396867218,
            "challenge": 0.00072793734436,
            "description": "Scenario-controlled intracellular calcium value."
          },
          "ryanodine_receptor_pool": {
            "unit": "dimensionless",
            "label": "ryanodine receptor pool",
            "active": false,
            "baseline": 0,
            "recovery": 0,
            "challenge": 0,
            "description": "Scenario-controlled ryanodine receptor pool value."
          }
        },
        "scenario_name": "Calcium activation challenge",
        "baseline_until": 0.25,
        "challenge_until": 0.75,
        "scenario_description": "Baseline is followed by a intracellular calcium challenge and recovery period."
      },
      "provenance": {
        "owned_path": "owned/models/iyer2007_arrhythmia_cardiac_death_scenario"
      }
    },
    {
      "path": "owned/models/iyer2007_arrhythmia_cardiac_death_core",
      "alias": "iyer2007_arrhythmia_cardiac_death_core",
      "parameters": {
        "model_path": "data/MODEL1006230030.xml",
        "integration_step": 0.001
      },
      "provenance": {
        "owned_path": "owned/models/iyer2007_arrhythmia_cardiac_death_core"
      }
    },
    {
      "path": "owned/models/iyer2007_arrhythmia_cardiac_death_viz",
      "alias": "iyer2007_arrhythmia_cardiac_death_viz",
      "parameters": {
        "lab_title": "Iyer2007 Arrhythmia Cardiac Death",
        "lab_question": "Does abnormal calcium handling create arrhythmogenic behaviour?",
        "integration_step": 0.001
      },
      "provenance": {
        "owned_path": "owned/models/iyer2007_arrhythmia_cardiac_death_viz"
      }
    }
  ],
  "wiring": [
    {
      "to": [
        "iyer2007_arrhythmia_cardiac_death_core.temperature"
      ],
      "from": "iyer2007_arrhythmia_cardiac_death_scenario.temperature"
    },
    {
      "to": [
        "iyer2007_arrhythmia_cardiac_death_core.isoproterenol_drive"
      ],
      "from": "iyer2007_arrhythmia_cardiac_death_scenario.isoproterenol_drive"
    },
    {
      "to": [
        "iyer2007_arrhythmia_cardiac_death_core.calsequestrin_buffer"
      ],
      "from": "iyer2007_arrhythmia_cardiac_death_scenario.calsequestrin_buffer"
    },
    {
      "to": [
        "iyer2007_arrhythmia_cardiac_death_core.ryanodine_receptor_pool"
      ],
      "from": "iyer2007_arrhythmia_cardiac_death_scenario.ryanodine_receptor_pool"
    },
    {
      "to": [
        "iyer2007_arrhythmia_cardiac_death_core.intracellular_calcium"
      ],
      "from": "iyer2007_arrhythmia_cardiac_death_scenario.intracellular_calcium"
    },
    {
      "to": [
        "iyer2007_arrhythmia_cardiac_death_viz.scenario_metadata"
      ],
      "from": "iyer2007_arrhythmia_cardiac_death_scenario.scenario_metadata"
    },
    {
      "to": [
        "iyer2007_arrhythmia_cardiac_death_viz.state"
      ],
      "from": "iyer2007_arrhythmia_cardiac_death_core.state"
    },
    {
      "to": [
        "iyer2007_arrhythmia_cardiac_death_viz.species_labels"
      ],
      "from": "iyer2007_arrhythmia_cardiac_death_core.species_labels"
    }
  ],
  "runtime": {
    "duration": 1,
    "initial_inputs": {
      "iyer2007_arrhythmia_cardiac_death_core": {
        "integration_step": 0.001,
        "initial_conditions": {
          "payload": {}
        },
        "parameter_overrides": {
          "payload": {}
        }
      }
    },
    "communication_step": 0.001
  },
  "description": "Two-model lab for Iyer2007 Arrhythmia Cardiac Death: a core SBML simulator wired into a dedicated visualization sub-model that turns the raw state into friendly timeseries and a plain-language summary. This a model from the article: Mechanisms of abnormal calcium homeostasis in mutations responsible forcatecholaminergic polymorphic ventricular tachycardia. It can be used to explore cardiac dynamics and compare response patterns across conditions.",
  "schema_version": "2.0"
}