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Coletti2020 - QSP model of prostate cancer immunotherapy Lab

About lab

This model is based on the publication:Coletti R, Leonardelli L, Parolo S, Marchetti L. A QSP model of prostate cancer immunotherapy to identify effective combination therapies.

Runtime

Duration10
Comms Step1

Runs

Total0
Completed0
Failed0

Metadata

Packagecoletti2020-qsp-model-of-prostate-cancer-immunotherapy-lab
Created2026-05-16
Updated2026-05-16
biomodels_ebicurateddrug-responsefaithfulimmunologyimmunotherapymicroenvironmentoncologypharmacologyphysiologysbmlsignal-transductionsignalingsystemsbiologytumor-growthvisualisation

Manifest

{
  "io": {
    "inputs": [
      {
        "name": "k_anti_il_source_parameter",
        "label": "K antiIl source parameter",
        "units": "native SBML value",
        "default": 0.714,
        "maps_to": "oncology_sbml_coletti2020_qsp_model_of_prostate_cancer_immunot_model2109110002_model.k_anti_il_source_parameter",
        "description": "K antiIl source parameter. Maps to bundled SBML parameter `k_antiIl`."
      }
    ],
    "outputs": [
      {
        "name": "x_1",
        "maps_to": "oncology_sbml_coletti2020_qsp_model_of_prostate_cancer_immunot_model2109110002_model.x_1",
        "description": "X 1 observable. Maps to SBML symbol `X_1`."
      },
      {
        "name": "a",
        "maps_to": "oncology_sbml_coletti2020_qsp_model_of_prostate_cancer_immunot_model2109110002_model.a",
        "description": "A observable. Maps to SBML symbol `A`."
      },
      {
        "name": "d_m",
        "maps_to": "oncology_sbml_coletti2020_qsp_model_of_prostate_cancer_immunot_model2109110002_model.d_m",
        "description": "D m observable. Maps to SBML symbol `D_m`."
      },
      {
        "name": "c_2",
        "maps_to": "oncology_sbml_coletti2020_qsp_model_of_prostate_cancer_immunot_model2109110002_model.c_2",
        "description": "C 2 observable. Maps to SBML symbol `C_2`."
      },
      {
        "name": "i_2",
        "maps_to": "oncology_sbml_coletti2020_qsp_model_of_prostate_cancer_immunot_model2109110002_model.i_2",
        "description": "I 2 observable. Maps to SBML symbol `I_2`."
      },
      {
        "name": "normal_cells",
        "maps_to": "oncology_sbml_coletti2020_qsp_model_of_prostate_cancer_immunot_model2109110002_model.normal_cells",
        "description": "N observable. Maps to SBML symbol `N`."
      },
      {
        "name": "state",
        "maps_to": "oncology_sbml_coletti2020_qsp_model_of_prostate_cancer_immunot_model2109110002_model.state",
        "description": "Full raw SBML observable record for reproducibility and downstream visualisation."
      },
      {
        "name": "summary",
        "maps_to": "oncology_sbml_coletti2020_qsp_model_of_prostate_cancer_immunot_model2109110002_model.summary",
        "description": "Change and peak summary across the simulated SBML observables."
      },
      {
        "name": "species_labels",
        "maps_to": "oncology_sbml_coletti2020_qsp_model_of_prostate_cancer_immunot_model2109110002_model.species_labels",
        "description": "Mapping from selected raw SBML observable symbols to display labels."
      }
    ]
  },
  "tags": [
    "biomodels_ebi",
    "curated",
    "drug-response",
    "faithful",
    "immunology",
    "immunotherapy",
    "microenvironment",
    "oncology",
    "pharmacology",
    "physiology",
    "sbml",
    "signal-transduction",
    "signaling",
    "systemsbiology",
    "tumor-growth"
  ],
  "title": "Coletti2020 - QSP model of prostate cancer immunotherapy Lab",
  "models": [
    {
      "path": "owned/models/oncology_sbml_coletti2020_qsp_model_of_prostate_cancer_immunot_model2109110002_model",
      "alias": "oncology_sbml_coletti2020_qsp_model_of_prostate_cancer_immunot_model2109110002_model",
      "provenance": {
        "owned_path": "owned/models/oncology_sbml_coletti2020_qsp_model_of_prostate_cancer_immunot_model2109110002_model"
      }
    },
    {
      "path": "owned/models/visualisation",
      "alias": "visualisation",
      "provenance": {
        "owned_path": "owned/models/visualisation"
      }
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.oncology_sbml_coletti2020_qsp_model_of_prostate_cancer_immunot_model2109110002_model_state"
      ],
      "from": "oncology_sbml_coletti2020_qsp_model_of_prostate_cancer_immunot_model2109110002_model.state"
    },
    {
      "to": [
        "visualisation.oncology_sbml_coletti2020_qsp_model_of_prostate_cancer_immunot_model2109110002_model_summary"
      ],
      "from": "oncology_sbml_coletti2020_qsp_model_of_prostate_cancer_immunot_model2109110002_model.summary"
    },
    {
      "to": [
        "visualisation.oncology_sbml_coletti2020_qsp_model_of_prostate_cancer_immunot_model2109110002_model_species_labels"
      ],
      "from": "oncology_sbml_coletti2020_qsp_model_of_prostate_cancer_immunot_model2109110002_model.species_labels"
    }
  ],
  "runtime": {
    "duration": 10,
    "initial_inputs": {},
    "communication_step": 1
  },
  "description": "This model is based on the publication:Coletti R, Leonardelli L, Parolo S, Marchetti L. A QSP model of prostate cancer immunotherapy to identify effective combination therapies.",
  "schema_version": "2.0"
}

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