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Kesmir1999 - De Boer Mathematical Germinal Centre Kinetics Termination Lab

About lab

Source-faithful physiology lab for Kesmir, Deboer, 1999. Public controls and outputs are mapped to real source symbols for source-model physiology.

Runtime

Duration0.01
Comms Step0.01
Settle Steps1

Runs

Total0
Completed0
Failed0

Metadata

Packagekesmir1999-de-boer-mathematical-germinal-centre-kinetics-termina
Created2026-05-23
Updated2026-05-23
physiologycellmlphysiomefaithfulvisualisationother

Manifest

{
  "io": {
    "inputs": [
      {
        "name": "initial_ag_bound_centrocyte",
        "label": "Initial Ag Bound Centrocyte",
        "maps_to": "physiology_cellml_kesmir_deboer_1999_kesmirdeboer1999_model.initial_ag_bound_centrocyte",
        "description": "Initial value for Ag Bound Centrocyte. Maps to source symbol `C_star`. Units: cells_per_GC. Naming evidence: source metadata names `C_star` as `Ag-bound centrocyte`.",
        "accepted_units": [
          "cells_per_GC"
        ]
      },
      {
        "name": "initial_centroblast_0_divisions",
        "label": "Initial Centroblast 0 Divisions",
        "maps_to": "physiology_cellml_kesmir_deboer_1999_kesmirdeboer1999_model.initial_centroblast_0_divisions",
        "description": "Initial value for Centroblast 0 Divisions. Maps to source symbol `B0`. Units: cells_per_GC. Naming evidence: source metadata names `B0` as `centroblast 0 divisions`.",
        "accepted_units": [
          "cells_per_GC"
        ]
      }
    ],
    "outputs": [
      {
        "name": "state",
        "label": "Selected Source State",
        "maps_to": "physiology_cellml_kesmir_deboer_1999_kesmirdeboer1999_model.state"
      },
      {
        "name": "summary",
        "label": "Simulation Summary",
        "maps_to": "physiology_cellml_kesmir_deboer_1999_kesmirdeboer1999_model.summary"
      },
      {
        "name": "trajectory",
        "label": "Source Trajectory",
        "maps_to": "physiology_cellml_kesmir_deboer_1999_kesmirdeboer1999_model.trajectory"
      },
      {
        "name": "variable_labels",
        "label": "Observable Labels",
        "maps_to": "physiology_cellml_kesmir_deboer_1999_kesmirdeboer1999_model.variable_labels"
      },
      {
        "name": "centroblast_0_divisions",
        "label": "Centroblast 0 Divisions",
        "maps_to": "physiology_cellml_kesmir_deboer_1999_kesmirdeboer1999_model.centroblast_0_divisions",
        "description": "Centroblast 0 Divisions. Maps to source symbol `B0`. Units: cells_per_GC. Naming evidence: source metadata names `B0` as `centroblast 0 divisions`."
      },
      {
        "name": "centroblast_10_divisions",
        "label": "Centroblast 10 Divisions",
        "maps_to": "physiology_cellml_kesmir_deboer_1999_kesmirdeboer1999_model.centroblast_10_divisions",
        "description": "Centroblast 10 Divisions. Maps to source symbol `B10`. Units: cells_per_GC. Naming evidence: source metadata names `B10` as `centroblast 10 divisions`."
      },
      {
        "name": "centroblast_1_division",
        "label": "Centroblast 1 Division",
        "maps_to": "physiology_cellml_kesmir_deboer_1999_kesmirdeboer1999_model.centroblast_1_division",
        "description": "Centroblast 1 Division. Maps to source symbol `B1`. Units: cells_per_GC. Naming evidence: source metadata names `B1` as `centroblast 1 division`."
      },
      {
        "name": "centroblast_2_divisions",
        "label": "Centroblast 2 Divisions",
        "maps_to": "physiology_cellml_kesmir_deboer_1999_kesmirdeboer1999_model.centroblast_2_divisions",
        "description": "Centroblast 2 Divisions. Maps to source symbol `B2`. Units: cells_per_GC. Naming evidence: source metadata names `B2` as `centroblast 2 divisions`."
      },
      {
        "name": "centroblast_3_divisions",
        "label": "Centroblast 3 Divisions",
        "maps_to": "physiology_cellml_kesmir_deboer_1999_kesmirdeboer1999_model.centroblast_3_divisions",
        "description": "Centroblast 3 Divisions. Maps to source symbol `B3`. Units: cells_per_GC. Naming evidence: source metadata names `B3` as `centroblast 3 divisions`."
      },
      {
        "name": "centrocyte_fdc_complex",
        "label": "Centrocyte Fdc Complex",
        "maps_to": "physiology_cellml_kesmir_deboer_1999_kesmirdeboer1999_model.centrocyte_fdc_complex",
        "description": "Centrocyte Fdc Complex. Maps to source symbol `CA`. Units: cells_per_GC. Naming evidence: source metadata names `CA` as `centrocyte-FDC complex`."
      }
    ]
  },
  "title": "Kesmir1999 - De Boer Mathematical Germinal Centre Kinetics Termination Lab",
  "models": [
    {
      "path": "owned/models/physiology_cellml_kesmir_deboer_1999_kesmirdeboer1999_model",
      "alias": "physiology_cellml_kesmir_deboer_1999_kesmirdeboer1999_model",
      "parameters": {
        "model_path": "data/kesmir_deboer_1999.cellml",
        "integration_step": 0.01
      },
      "provenance": {
        "owned_path": "owned/models/physiology_cellml_kesmir_deboer_1999_kesmirdeboer1999_model"
      }
    },
    {
      "path": "owned/models/visualisation",
      "alias": "visualisation",
      "provenance": {
        "owned_path": "owned/models/visualisation"
      }
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.physiology_cellml_kesmir_deboer_1999_kesmirdeboer1999_model_state"
      ],
      "from": "physiology_cellml_kesmir_deboer_1999_kesmirdeboer1999_model.state"
    },
    {
      "to": [
        "visualisation.physiology_cellml_kesmir_deboer_1999_kesmirdeboer1999_model_summary"
      ],
      "from": "physiology_cellml_kesmir_deboer_1999_kesmirdeboer1999_model.summary"
    },
    {
      "to": [
        "visualisation.physiology_cellml_kesmir_deboer_1999_kesmirdeboer1999_model_trajectory"
      ],
      "from": "physiology_cellml_kesmir_deboer_1999_kesmirdeboer1999_model.trajectory"
    },
    {
      "to": [
        "visualisation.physiology_cellml_kesmir_deboer_1999_kesmirdeboer1999_model_variable_labels"
      ],
      "from": "physiology_cellml_kesmir_deboer_1999_kesmirdeboer1999_model.variable_labels"
    }
  ],
  "runtime": {
    "duration": 0.01,
    "settle_steps": 1,
    "initial_inputs": {},
    "communication_step": 0.01
  },
  "description": "Source-faithful physiology lab for Kesmir, Deboer, 1999. Public controls and outputs are mapped to real source symbols for source-model physiology.",
  "schema_version": "2.0"
}

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