Niederer2006 Myocyte Relaxation Lab

{
  "io": {
    "inputs": [
      {
        "name": "integration_step",
        "maps_to": "niederer2006_myocyte_relaxation_core.integration_step"
      },
      {
        "name": "parameter_overrides",
        "maps_to": "niederer2006_myocyte_relaxation_core.parameter_overrides"
      },
      {
        "name": "initial_conditions",
        "maps_to": "niederer2006_myocyte_relaxation_core.initial_conditions"
      }
    ],
    "outputs": [
      {
        "name": "scenario_metadata",
        "maps_to": "niederer2006_myocyte_relaxation_scenario.scenario_metadata"
      },
      {
        "name": "state",
        "maps_to": "niederer2006_myocyte_relaxation_core.state"
      },
      {
        "name": "run_summary",
        "maps_to": "niederer2006_myocyte_relaxation_viz.run_summary"
      }
    ]
  },
  "title": "Niederer2006 Myocyte Relaxation Lab",
  "models": [
    {
      "path": "models/scenario",
      "alias": "niederer2006_myocyte_relaxation_scenario",
      "parameters": {
        "schedule": {
          "cooperativity": {
            "unit": "dimensionless",
            "label": "cooperativity",
            "active": false,
            "baseline": 0.008,
            "recovery": 0.008,
            "challenge": 0.008,
            "description": "Scenario-controlled cooperativity value."
          },
          "troponin_pool": {
            "unit": "dimensionless",
            "label": "troponin pool",
            "active": true,
            "baseline": 0.067593139865,
            "recovery": 0.067593139865,
            "challenge": 0.1013897097975,
            "description": "Scenario-controlled troponin pool value."
          },
          "relaxation_rate": {
            "unit": "dimensionless",
            "label": "relaxation rate",
            "active": false,
            "baseline": 0.002,
            "recovery": 0.002,
            "challenge": 0.002,
            "description": "Scenario-controlled relaxation rate value."
          }
        },
        "scenario_name": "Troponin pool challenge",
        "baseline_until": 0.25,
        "challenge_until": 0.75,
        "scenario_description": "Baseline is followed by a troponin pool challenge and recovery period."
      }
    },
    {
      "path": "./models/core",
      "alias": "niederer2006_myocyte_relaxation_core",
      "parameters": {
        "model_path": "data/MODEL8687196544.xml",
        "integration_step": 0.001
      }
    },
    {
      "path": "./models/viz",
      "alias": "niederer2006_myocyte_relaxation_viz",
      "parameters": {
        "lab_title": "Niederer2006 Myocyte Relaxation",
        "lab_question": "How quickly does the myocyte relax after calcium activation?",
        "integration_step": 0.001
      }
    }
  ],
  "wiring": [
    {
      "to": [
        "niederer2006_myocyte_relaxation_core.troponin_pool"
      ],
      "from": "niederer2006_myocyte_relaxation_scenario.troponin_pool"
    },
    {
      "to": [
        "niederer2006_myocyte_relaxation_core.relaxation_rate"
      ],
      "from": "niederer2006_myocyte_relaxation_scenario.relaxation_rate"
    },
    {
      "to": [
        "niederer2006_myocyte_relaxation_core.cooperativity"
      ],
      "from": "niederer2006_myocyte_relaxation_scenario.cooperativity"
    },
    {
      "to": [
        "niederer2006_myocyte_relaxation_viz.scenario_metadata"
      ],
      "from": "niederer2006_myocyte_relaxation_scenario.scenario_metadata"
    },
    {
      "to": [
        "niederer2006_myocyte_relaxation_viz.state"
      ],
      "from": "niederer2006_myocyte_relaxation_core.state"
    },
    {
      "to": [
        "niederer2006_myocyte_relaxation_viz.species_labels"
      ],
      "from": "niederer2006_myocyte_relaxation_core.species_labels"
    }
  ],
  "package": "niederer2006-myocyte-relaxation",
  "runtime": {
    "duration": 1,
    "initial_inputs": {
      "niederer2006_myocyte_relaxation_core": {
        "integration_step": 0.001,
        "initial_conditions": {
          "payload": {}
        },
        "parameter_overrides": {
          "payload": {}
        }
      }
    },
    "communication_step": 0.001
  },
  "version": "1.0.0",
  "description": "Two-model lab for Niederer2006 Myocyte Relaxation: a core SBML simulator wired into a dedicated visualization sub-model that turns the raw state into friendly timeseries and a plain-language summary. This a model from the article: A quantitative analysis of cardiac myocyte relaxation: a simulation study. It can be used to explore cardiac dynamics and compare response patterns across conditions.",
  "schema_version": "2.0"
}