Zhu2015 - Combined gemcitabine and birinapant in pancreatic cancer cells - mechanistic PD model Lab

{
  "io": {
    "inputs": [
      {
        "name": "gemcitabine_concentration",
        "label": "Gemcitabine Concentration",
        "units": "native SBML value",
        "default": 20,
        "maps_to": "oncology_sbml_zhu2015_combined_gemcitabine_and_birinapant_in_p_biomd0000000669_model.gemcitabine_concentration",
        "description": "Gemcitabine Concentration. Overrides bundled SBML parameter `C_g`."
      },
      {
        "name": "birinapant_concentration",
        "label": "Birinapant Concentration",
        "units": "native SBML value",
        "default": 500,
        "maps_to": "oncology_sbml_zhu2015_combined_gemcitabine_and_birinapant_in_p_biomd0000000669_model.birinapant_concentration",
        "description": "Birinapant Concentration. Overrides bundled SBML parameter `C_b`."
      },
      {
        "name": "initial_g1_cells",
        "label": "G1 Cells",
        "units": "native SBML value",
        "default": 113516,
        "maps_to": "oncology_sbml_zhu2015_combined_gemcitabine_and_birinapant_in_p_biomd0000000669_model.initial_g1_cells",
        "description": "Initial G1 Cells. Sets the initial value of bundled SBML symbol `G1`."
      },
      {
        "name": "initial_g2_cells",
        "label": "G2 Cells",
        "units": "native SBML value",
        "default": 81656,
        "maps_to": "oncology_sbml_zhu2015_combined_gemcitabine_and_birinapant_in_p_biomd0000000669_model.initial_g2_cells",
        "description": "Initial G2 Cells. Sets the initial value of bundled SBML symbol `G2`."
      }
    ],
    "outputs": [
      {
        "name": "g1_cells",
        "maps_to": "oncology_sbml_zhu2015_combined_gemcitabine_and_birinapant_in_p_biomd0000000669_model.g1_cells",
        "description": "G1 Cells observable. Maps to SBML symbol `G1`."
      },
      {
        "name": "s_phase_cells",
        "maps_to": "oncology_sbml_zhu2015_combined_gemcitabine_and_birinapant_in_p_biomd0000000669_model.s_phase_cells",
        "description": "S-Phase Cells observable. Maps to SBML symbol `S`."
      },
      {
        "name": "g2_cells",
        "maps_to": "oncology_sbml_zhu2015_combined_gemcitabine_and_birinapant_in_p_biomd0000000669_model.g2_cells",
        "description": "G2 Cells observable. Maps to SBML symbol `G2`."
      },
      {
        "name": "apoptotic_response",
        "maps_to": "oncology_sbml_zhu2015_combined_gemcitabine_and_birinapant_in_p_biomd0000000669_model.apoptotic_response",
        "description": "Apoptotic Response observable. Maps to SBML symbol `R_apo`."
      },
      {
        "name": "other_response",
        "maps_to": "oncology_sbml_zhu2015_combined_gemcitabine_and_birinapant_in_p_biomd0000000669_model.other_response",
        "description": "Other Response observable. Maps to SBML symbol `R_other`."
      },
      {
        "name": "state",
        "maps_to": "oncology_sbml_zhu2015_combined_gemcitabine_and_birinapant_in_p_biomd0000000669_model.state",
        "description": "Full raw SBML observable record for reproducibility and downstream visualisation."
      },
      {
        "name": "summary",
        "maps_to": "oncology_sbml_zhu2015_combined_gemcitabine_and_birinapant_in_p_biomd0000000669_model.summary",
        "description": "Change and peak summary across the simulated SBML observables."
      },
      {
        "name": "species_labels",
        "maps_to": "oncology_sbml_zhu2015_combined_gemcitabine_and_birinapant_in_p_biomd0000000669_model.species_labels",
        "description": "Mapping from selected raw SBML observable symbols to display labels."
      }
    ]
  },
  "tags": [
    "biomodels_ebi",
    "chemotherapy",
    "curated",
    "drug-response",
    "faithful",
    "oncology",
    "pharmacology",
    "physiology",
    "sbml",
    "systemsbiology",
    "tumor-growth"
  ],
  "title": "Zhu2015 - Combined gemcitabine and birinapant in pancreatic cancer cells - mechanistic PD model Lab",
  "models": [
    {
      "path": "owned/models/oncology_sbml_zhu2015_combined_gemcitabine_and_birinapant_in_p_biomd0000000669_model",
      "alias": "oncology_sbml_zhu2015_combined_gemcitabine_and_birinapant_in_p_biomd0000000669_model",
      "provenance": {
        "owned_path": "owned/models/oncology_sbml_zhu2015_combined_gemcitabine_and_birinapant_in_p_biomd0000000669_model"
      }
    },
    {
      "path": "owned/models/visualisation",
      "alias": "visualisation",
      "provenance": {
        "owned_path": "owned/models/visualisation"
      }
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.oncology_sbml_zhu2015_combined_gemcitabine_and_birinapant_in_p_biomd0000000669_model_state"
      ],
      "from": "oncology_sbml_zhu2015_combined_gemcitabine_and_birinapant_in_p_biomd0000000669_model.state"
    },
    {
      "to": [
        "visualisation.oncology_sbml_zhu2015_combined_gemcitabine_and_birinapant_in_p_biomd0000000669_model_summary"
      ],
      "from": "oncology_sbml_zhu2015_combined_gemcitabine_and_birinapant_in_p_biomd0000000669_model.summary"
    },
    {
      "to": [
        "visualisation.oncology_sbml_zhu2015_combined_gemcitabine_and_birinapant_in_p_biomd0000000669_model_species_labels"
      ],
      "from": "oncology_sbml_zhu2015_combined_gemcitabine_and_birinapant_in_p_biomd0000000669_model.species_labels"
    }
  ],
  "runtime": {
    "duration": 10,
    "initial_inputs": {},
    "communication_step": 1
  },
  "description": "Zhu2015 - combined gemcitabine and birinapantin pancreatic cancer cells - mechanistic PD model Mechanistic mathematical model toillustrate the effectiveness of combination chemotherapy involvinggemcit. It can be used to explore tumor-related dynamics and compare treatment-response behavior across conditions.",
  "schema_version": "2.0"
}