Cappuccio2006 - Cancer immunotherapy by interleukin-21 Lab

{
  "io": {
    "inputs": [
      {
        "name": "initial_natural_killer_t_cells",
        "label": "Initial Natural Killer T Cells",
        "units": "native source value",
        "default": 1.95185,
        "maps_to": "immunology_sbml_cappuccio2006_cancer_immunotherapy_by_interleuki_biomd0000000761_model.initial_natural_killer_t_cells",
        "description": "Initial Natural Killer T Cells. Sets the initial value of bundled SBML species `X`."
      },
      {
        "name": "initial_cd8_t_cells",
        "label": "Initial CD8 T Cells",
        "units": "native source value",
        "default": 0.066,
        "maps_to": "immunology_sbml_cappuccio2006_cancer_immunotherapy_by_interleuki_biomd0000000761_model.initial_cd8_t_cells",
        "description": "Initial CD8 T Cells. Sets the initial value of bundled SBML species `Y`."
      },
      {
        "name": "initial_tumor_sa",
        "label": "Initial Tumor Sa",
        "units": "native source value",
        "default": 2,
        "maps_to": "immunology_sbml_cappuccio2006_cancer_immunotherapy_by_interleuki_biomd0000000761_model.initial_tumor_sa",
        "description": "Initial Tumor Sa. Sets the initial value of bundled SBML species `Z`."
      },
      {
        "name": "initial_interleukin_21",
        "label": "Initial Interleukin 21",
        "units": "native source value",
        "default": 0,
        "maps_to": "immunology_sbml_cappuccio2006_cancer_immunotherapy_by_interleuki_biomd0000000761_model.initial_interleukin_21",
        "description": "Initial Interleukin 21. Sets the initial value of bundled SBML species `U`."
      },
      {
        "name": "initial_cd8_memory_factor",
        "label": "Initial CD8 Memory Factor",
        "units": "native source value",
        "default": 0,
        "maps_to": "immunology_sbml_cappuccio2006_cancer_immunotherapy_by_interleuki_biomd0000000761_model.initial_cd8_memory_factor",
        "description": "Initial CD8 Memory Factor. Sets the initial value of bundled SBML species `M`."
      },
      {
        "name": "tumor_growth_rate",
        "label": "Tumor Growth Rate",
        "units": "unit_6",
        "default": 5.1,
        "maps_to": "immunology_sbml_cappuccio2006_cancer_immunotherapy_by_interleuki_biomd0000000761_model.tumor_growth_rate",
        "description": "Tumor Growth Rate. Sets bundled SBML parameter `c`."
      },
      {
        "name": "tumor_killing_by_natural_killer_cells_rate",
        "label": "Tumor Killing By Natural Killer Cells Rate",
        "units": "unit_7",
        "default": 0.05,
        "maps_to": "immunology_sbml_cappuccio2006_cancer_immunotherapy_by_interleuki_biomd0000000761_model.tumor_killing_by_natural_killer_cells_rate",
        "description": "Tumor Killing By Natural Killer Cells Rate. Sets bundled SBML parameter `k1`."
      },
      {
        "name": "tumor_killing_by_cd8_t_cells_rate",
        "label": "Tumor Killing By CD8 T Cells Rate",
        "units": "unit_7",
        "default": 0.0485,
        "maps_to": "immunology_sbml_cappuccio2006_cancer_immunotherapy_by_interleuki_biomd0000000761_model.tumor_killing_by_cd8_t_cells_rate",
        "description": "Tumor Killing By CD8 T Cells Rate. Sets bundled SBML parameter `k2`."
      }
    ],
    "outputs": [
      {
        "name": "natural_killer_t_cells",
        "maps_to": "immunology_sbml_cappuccio2006_cancer_immunotherapy_by_interleuki_biomd0000000761_model.natural_killer_t_cells"
      },
      {
        "name": "cd8_t_cells",
        "maps_to": "immunology_sbml_cappuccio2006_cancer_immunotherapy_by_interleuki_biomd0000000761_model.cd8_t_cells"
      },
      {
        "name": "tumor_sa",
        "maps_to": "immunology_sbml_cappuccio2006_cancer_immunotherapy_by_interleuki_biomd0000000761_model.tumor_sa"
      },
      {
        "name": "interleukin_21",
        "maps_to": "immunology_sbml_cappuccio2006_cancer_immunotherapy_by_interleuki_biomd0000000761_model.interleukin_21"
      },
      {
        "name": "cd8_memory_factor",
        "maps_to": "immunology_sbml_cappuccio2006_cancer_immunotherapy_by_interleuki_biomd0000000761_model.cd8_memory_factor"
      },
      {
        "name": "state",
        "maps_to": "immunology_sbml_cappuccio2006_cancer_immunotherapy_by_interleuki_biomd0000000761_model.state"
      },
      {
        "name": "summary",
        "maps_to": "immunology_sbml_cappuccio2006_cancer_immunotherapy_by_interleuki_biomd0000000761_model.summary"
      },
      {
        "name": "species_labels",
        "maps_to": "immunology_sbml_cappuccio2006_cancer_immunotherapy_by_interleuki_biomd0000000761_model.species_labels"
      }
    ]
  },
  "title": "Cappuccio2006 - Cancer immunotherapy by interleukin-21 Lab",
  "models": [
    {
      "path": "owned/models/immunology_sbml_cappuccio2006_cancer_immunotherapy_by_interleuki_biomd0000000761_model",
      "alias": "immunology_sbml_cappuccio2006_cancer_immunotherapy_by_interleuki_biomd0000000761_model",
      "provenance": {
        "owned_path": "owned/models/immunology_sbml_cappuccio2006_cancer_immunotherapy_by_interleuki_biomd0000000761_model"
      }
    },
    {
      "path": "owned/models/visualisation",
      "alias": "visualisation",
      "provenance": {
        "owned_path": "owned/models/visualisation"
      }
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.immunology_sbml_cappuccio2006_cancer_immunotherapy_by_interleuki_biomd0000000761_model_state"
      ],
      "from": "immunology_sbml_cappuccio2006_cancer_immunotherapy_by_interleuki_biomd0000000761_model.state"
    },
    {
      "to": [
        "visualisation.immunology_sbml_cappuccio2006_cancer_immunotherapy_by_interleuki_biomd0000000761_model_summary"
      ],
      "from": "immunology_sbml_cappuccio2006_cancer_immunotherapy_by_interleuki_biomd0000000761_model.summary"
    },
    {
      "to": [
        "visualisation.immunology_sbml_cappuccio2006_cancer_immunotherapy_by_interleuki_biomd0000000761_model_species_labels"
      ],
      "from": "immunology_sbml_cappuccio2006_cancer_immunotherapy_by_interleuki_biomd0000000761_model.species_labels"
    }
  ],
  "runtime": {
    "duration": 10,
    "initial_inputs": {},
    "communication_step": 1
  },
  "description": "This model describes the effects of Il-21 on tumor eradication via natural killer cell-mediated and CD8+ T-cell-mediated lysis of tumor cells. The model demonstrates changes in growth dynamics in noni.",
  "schema_version": "2.0"
}