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Tyson1999 - Simple Mathematical Circadian Rhythms Based Dimerisation Lab

About lab

Source-faithful physiology lab for Tyson, Hong, Thron, Novak, 1999. Public controls and outputs are mapped to real source symbols for oscillatory physiology.

Runtime

Duration0.01
Comms Step0.01
Settle Steps1

Runs

Total0
Completed0
Failed0

Metadata

Packagetyson1999-simple-mathematical-circadian-rhythms-based-dimerisati
Created2026-05-23
Updated2026-05-23
physiologycellmlphysiomefaithfulvisualisationother

Manifest

{
  "io": {
    "inputs": [
      {
        "name": "initial_m_rna_concentration",
        "label": "Initial M RNA Concentration",
        "maps_to": "physiology_cellml_tyson_hong_thron_novak_1999_tysonhongthronnovak1999_model.initial_m_rna_concentration",
        "description": "Initial value for M RNA Concentration. Maps to source symbol `M`. Units: nanomolar. Naming evidence: source metadata names `M` as `mRNA concentration`.",
        "accepted_units": [
          "nanomolar"
        ]
      },
      {
        "name": "initial_total_protein_concentration",
        "label": "Initial Total Protein Concentration",
        "maps_to": "physiology_cellml_tyson_hong_thron_novak_1999_tysonhongthronnovak1999_model.initial_total_protein_concentration",
        "description": "Initial value for Total Protein Concentration. Maps to source symbol `Pt`. Units: nanomolar. Naming evidence: source metadata names `Pt` as `total protein concentration`.",
        "accepted_units": [
          "nanomolar"
        ]
      }
    ],
    "outputs": [
      {
        "name": "state",
        "label": "Selected Source State",
        "maps_to": "physiology_cellml_tyson_hong_thron_novak_1999_tysonhongthronnovak1999_model.state"
      },
      {
        "name": "summary",
        "label": "Simulation Summary",
        "maps_to": "physiology_cellml_tyson_hong_thron_novak_1999_tysonhongthronnovak1999_model.summary"
      },
      {
        "name": "trajectory",
        "label": "Source Trajectory",
        "maps_to": "physiology_cellml_tyson_hong_thron_novak_1999_tysonhongthronnovak1999_model.trajectory"
      },
      {
        "name": "variable_labels",
        "label": "Observable Labels",
        "maps_to": "physiology_cellml_tyson_hong_thron_novak_1999_tysonhongthronnovak1999_model.variable_labels"
      },
      {
        "name": "m_rna_concentration",
        "label": "M RNA Concentration",
        "maps_to": "physiology_cellml_tyson_hong_thron_novak_1999_tysonhongthronnovak1999_model.m_rna_concentration",
        "description": "M RNA Concentration. Maps to source symbol `M`. Units: nanomolar. Naming evidence: source metadata names `M` as `mRNA concentration`."
      },
      {
        "name": "total_protein_concentration",
        "label": "Total Protein Concentration",
        "maps_to": "physiology_cellml_tyson_hong_thron_novak_1999_tysonhongthronnovak1999_model.total_protein_concentration",
        "description": "Total Protein Concentration. Maps to source symbol `Pt`. Units: nanomolar. Naming evidence: source metadata names `Pt` as `total protein concentration`."
      },
      {
        "name": "keq",
        "label": "Keq",
        "maps_to": "physiology_cellml_tyson_hong_thron_novak_1999_tysonhongthronnovak1999_model.keq",
        "description": "Keq. Maps to source symbol `Keq`. Units: per_nanomolar. Naming evidence: source symbol, component, or units provide a direct public name."
      },
      {
        "name": "kp1",
        "label": "Kp1",
        "maps_to": "physiology_cellml_tyson_hong_thron_novak_1999_tysonhongthronnovak1999_model.kp1",
        "description": "Kp1. Maps to source symbol `kp1`. Units: flux. Naming evidence: source symbol, component, or units provide a direct public name."
      },
      {
        "name": "kp2",
        "label": "Kp2",
        "maps_to": "physiology_cellml_tyson_hong_thron_novak_1999_tysonhongthronnovak1999_model.kp2",
        "description": "Kp2. Maps to source symbol `kp2`. Units: flux. Naming evidence: source symbol, component, or units provide a direct public name."
      },
      {
        "name": "model_parameter_q",
        "label": "Model Parameter Q (source q)",
        "maps_to": "physiology_cellml_tyson_hong_thron_novak_1999_tysonhongthronnovak1999_model.model_parameter_q",
        "description": "Model Parameter Q (source q). Maps to source symbol `q`. Units: dimensionless. Naming evidence: source symbol is dimensionless but lacks enough evidence for a biological label."
      }
    ]
  },
  "title": "Tyson1999 - Simple Mathematical Circadian Rhythms Based Dimerisation Lab",
  "models": [
    {
      "path": "owned/models/physiology_cellml_tyson_hong_thron_novak_1999_tysonhongthronnovak1999_model",
      "alias": "physiology_cellml_tyson_hong_thron_novak_1999_tysonhongthronnovak1999_model",
      "parameters": {
        "model_path": "data/tyson_hong_thron_novak_1999.cellml",
        "integration_step": 0.01
      },
      "provenance": {
        "owned_path": "owned/models/physiology_cellml_tyson_hong_thron_novak_1999_tysonhongthronnovak1999_model"
      }
    },
    {
      "path": "owned/models/visualisation",
      "alias": "visualisation",
      "provenance": {
        "owned_path": "owned/models/visualisation"
      }
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.physiology_cellml_tyson_hong_thron_novak_1999_tysonhongthronnovak1999_model_state"
      ],
      "from": "physiology_cellml_tyson_hong_thron_novak_1999_tysonhongthronnovak1999_model.state"
    },
    {
      "to": [
        "visualisation.physiology_cellml_tyson_hong_thron_novak_1999_tysonhongthronnovak1999_model_summary"
      ],
      "from": "physiology_cellml_tyson_hong_thron_novak_1999_tysonhongthronnovak1999_model.summary"
    },
    {
      "to": [
        "visualisation.physiology_cellml_tyson_hong_thron_novak_1999_tysonhongthronnovak1999_model_trajectory"
      ],
      "from": "physiology_cellml_tyson_hong_thron_novak_1999_tysonhongthronnovak1999_model.trajectory"
    },
    {
      "to": [
        "visualisation.physiology_cellml_tyson_hong_thron_novak_1999_tysonhongthronnovak1999_model_variable_labels"
      ],
      "from": "physiology_cellml_tyson_hong_thron_novak_1999_tysonhongthronnovak1999_model.variable_labels"
    }
  ],
  "runtime": {
    "duration": 0.01,
    "settle_steps": 1,
    "initial_inputs": {},
    "communication_step": 0.01
  },
  "description": "Source-faithful physiology lab for Tyson, Hong, Thron, Novak, 1999. Public controls and outputs are mapped to real source symbols for oscillatory physiology.",
  "schema_version": "2.0"
}

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