Bae2017 - Mathematical analysis of circadian disruption and metabolic re-entrainment of hepatic gluconeogenesis Lab

{
  "io": {
    "inputs": [
      {
        "name": "initial_crh",
        "units": "native SBML value",
        "default": 1,
        "maps_to": "metabolism_sbml_bae2017_mathematical_analysis_of_circadian_disru_biomd0000001005_model.initial_crh",
        "description": "Initial condition for crh. Maps to bundled SBML symbol `CRH`. Applied before the Tellurium simulation starts; this does not change kinetic parameters or equations. Default from bundled SBML initial value."
      },
      {
        "name": "initial_acth",
        "units": "native SBML value",
        "default": 1,
        "maps_to": "metabolism_sbml_bae2017_mathematical_analysis_of_circadian_disru_biomd0000001005_model.initial_acth",
        "description": "Initial condition for acth. Maps to bundled SBML symbol `ACTH`. Applied before the Tellurium simulation starts; this does not change kinetic parameters or equations. Default from bundled SBML initial value."
      },
      {
        "name": "initial_metabolic_pathway_state_3",
        "units": "native SBML value",
        "default": 1,
        "maps_to": "metabolism_sbml_bae2017_mathematical_analysis_of_circadian_disru_biomd0000001005_model.initial_metabolic_pathway_state_3",
        "description": "Initial condition for metabolic pathway state 3. Maps to bundled SBML symbol `F_HPA`. Applied before the Tellurium simulation starts; this does not change kinetic parameters or equations. Default from bundled SBML initial value."
      },
      {
        "name": "initial_metabolic_pathway_state_4_cytosolic",
        "units": "native SBML value",
        "default": 1,
        "maps_to": "metabolism_sbml_bae2017_mathematical_analysis_of_circadian_disru_biomd0000001005_model.initial_metabolic_pathway_state_4_cytosolic",
        "description": "Initial condition for metabolic pathway state 4 cytosolic. Maps to bundled SBML symbol `F_Cell`. Applied before the Tellurium simulation starts; this does not change kinetic parameters or equations. Default from bundled SBML initial value."
      },
      {
        "name": "initial_metabolic_pathway_state_5",
        "units": "native SBML value",
        "default": 1,
        "maps_to": "metabolism_sbml_bae2017_mathematical_analysis_of_circadian_disru_biomd0000001005_model.initial_metabolic_pathway_state_5",
        "description": "Initial condition for metabolic pathway state 5. Maps to bundled SBML symbol `y1`. Applied before the Tellurium simulation starts; this does not change kinetic parameters or equations. Default from bundled SBML initial value."
      }
    ],
    "outputs": [
      {
        "name": "crh",
        "maps_to": "metabolism_sbml_bae2017_mathematical_analysis_of_circadian_disru_biomd0000001005_model.crh"
      },
      {
        "name": "acth",
        "maps_to": "metabolism_sbml_bae2017_mathematical_analysis_of_circadian_disru_biomd0000001005_model.acth"
      },
      {
        "name": "metabolic_pathway_state_3",
        "maps_to": "metabolism_sbml_bae2017_mathematical_analysis_of_circadian_disru_biomd0000001005_model.metabolic_pathway_state_3"
      },
      {
        "name": "metabolic_pathway_state_4_cytosolic",
        "maps_to": "metabolism_sbml_bae2017_mathematical_analysis_of_circadian_disru_biomd0000001005_model.metabolic_pathway_state_4_cytosolic"
      },
      {
        "name": "metabolic_pathway_state_5",
        "maps_to": "metabolism_sbml_bae2017_mathematical_analysis_of_circadian_disru_biomd0000001005_model.metabolic_pathway_state_5"
      },
      {
        "name": "observable_values",
        "maps_to": "metabolism_sbml_bae2017_mathematical_analysis_of_circadian_disru_biomd0000001005_model.observable_values"
      },
      {
        "name": "run_summary",
        "maps_to": "metabolism_sbml_bae2017_mathematical_analysis_of_circadian_disru_biomd0000001005_model.run_summary"
      },
      {
        "name": "observable_labels",
        "maps_to": "metabolism_sbml_bae2017_mathematical_analysis_of_circadian_disru_biomd0000001005_model.observable_labels"
      }
    ]
  },
  "title": "Bae2017 - Mathematical analysis of circadian disruption and metabolic re-entrainment of hepatic gluconeogenesis Lab",
  "models": [
    {
      "path": "owned/models/metabolism_sbml_bae2017_mathematical_analysis_of_circadian_disru_biomd0000001005_model",
      "alias": "metabolism_sbml_bae2017_mathematical_analysis_of_circadian_disru_biomd0000001005_model",
      "parameters": {
        "model_path": "data/BIOMD0000001005.xml",
        "integration_step": 0.1
      },
      "provenance": {
        "owned_path": "owned/models/metabolism_sbml_bae2017_mathematical_analysis_of_circadian_disru_biomd0000001005_model"
      }
    },
    {
      "path": "owned/models/visualisation",
      "alias": "visualisation",
      "provenance": {
        "owned_path": "owned/models/visualisation"
      }
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.metabolism_sbml_bae2017_mathematical_analysis_of_circadian_disru_biomd0000001005_model_observable_values"
      ],
      "from": "metabolism_sbml_bae2017_mathematical_analysis_of_circadian_disru_biomd0000001005_model.observable_values"
    },
    {
      "to": [
        "visualisation.metabolism_sbml_bae2017_mathematical_analysis_of_circadian_disru_biomd0000001005_model_run_summary"
      ],
      "from": "metabolism_sbml_bae2017_mathematical_analysis_of_circadian_disru_biomd0000001005_model.run_summary"
    },
    {
      "to": [
        "visualisation.metabolism_sbml_bae2017_mathematical_analysis_of_circadian_disru_biomd0000001005_model_observable_labels"
      ],
      "from": "metabolism_sbml_bae2017_mathematical_analysis_of_circadian_disru_biomd0000001005_model.observable_labels"
    }
  ],
  "runtime": {
    "duration": 10,
    "initial_inputs": {},
    "communication_step": 1
  },
  "description": "The circadian rhythms influence the metabolic activity from molecular level to tissue, organ, and host level. Disruption of the circadian rhythms manifests to the host's health as metabolic syndromes,.",
  "schema_version": "2.0"
}