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Proctor2017 Role Of Micrornas In Osteoarthritis 8 Lab

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Proctor2017- Role of microRNAs inosteoarthritis (miR140-SMAD3 double negative feedback) This model is described in the article: Computer simulation models as a tool to investigate the role of microRNA. It can be used to explore systemsbiology proctor2017 role of micrornas in dynamics and compare simulation behavior across conditions.

Runtime

Duration1
Comms Step0.1

Runs

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Completed0
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Metadata

Packageproctor2017-role-of-micrornas-in-osteoarthritis-8-lab
Created2026-05-17
Updated2026-05-17
generegulationsystemsbiologysbmlbiomodels_ebifaithfulcuratedvisualisation

Manifest

{
  "io": {
    "inputs": [
      {
        "name": "initial_tg_fb_a",
        "label": "Initial Tg Fb A",
        "maps_to": "systemsbiology_sbml_proctor2017_role_of_micrornas_in_osteoarthritis_model1705170000_model.initial_tg_fb_a",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `TGFb_A`."
      },
      {
        "name": "initial_tg_fb_i",
        "label": "Initial Tg Fb I",
        "maps_to": "systemsbiology_sbml_proctor2017_role_of_micrornas_in_osteoarthritis_model1705170000_model.initial_tg_fb_i",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `TGFb_I`."
      },
      {
        "name": "initial_mi_r140",
        "label": "Initial Mi R140",
        "maps_to": "systemsbiology_sbml_proctor2017_role_of_micrornas_in_osteoarthritis_model1705170000_model.initial_mi_r140",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `miR140`."
      },
      {
        "name": "initial_smad3",
        "label": "Initial Smad3",
        "maps_to": "systemsbiology_sbml_proctor2017_role_of_micrornas_in_osteoarthritis_model1705170000_model.initial_smad3",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `SMAD3`."
      },
      {
        "name": "initial_mi_r140_smad3_mrna",
        "label": "Initial Mi R140 Smad3 MRNA",
        "maps_to": "systemsbiology_sbml_proctor2017_role_of_micrornas_in_osteoarthritis_model1705170000_model.initial_mi_r140_smad3_mrna",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `miR140_SMAD3_mRNA`."
      },
      {
        "name": "initial_smad3_mrna",
        "label": "Initial Smad3 MRNA",
        "maps_to": "systemsbiology_sbml_proctor2017_role_of_micrornas_in_osteoarthritis_model1705170000_model.initial_smad3_mrna",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `SMAD3_mRNA`."
      }
    ],
    "outputs": [
      {
        "name": "state",
        "maps_to": "systemsbiology_sbml_proctor2017_role_of_micrornas_in_osteoarthritis_model1705170000_model.state"
      },
      {
        "name": "summary",
        "maps_to": "systemsbiology_sbml_proctor2017_role_of_micrornas_in_osteoarthritis_model1705170000_model.summary"
      },
      {
        "name": "species_labels",
        "maps_to": "systemsbiology_sbml_proctor2017_role_of_micrornas_in_osteoarthritis_model1705170000_model.species_labels"
      },
      {
        "name": "tg_fb_a",
        "maps_to": "systemsbiology_sbml_proctor2017_role_of_micrornas_in_osteoarthritis_model1705170000_model.tg_fb_a"
      },
      {
        "name": "tg_fb_i",
        "maps_to": "systemsbiology_sbml_proctor2017_role_of_micrornas_in_osteoarthritis_model1705170000_model.tg_fb_i"
      },
      {
        "name": "mi_r140",
        "maps_to": "systemsbiology_sbml_proctor2017_role_of_micrornas_in_osteoarthritis_model1705170000_model.mi_r140"
      },
      {
        "name": "smad3",
        "maps_to": "systemsbiology_sbml_proctor2017_role_of_micrornas_in_osteoarthritis_model1705170000_model.smad3"
      },
      {
        "name": "mi_r140_smad3_mrna",
        "maps_to": "systemsbiology_sbml_proctor2017_role_of_micrornas_in_osteoarthritis_model1705170000_model.mi_r140_smad3_mrna"
      },
      {
        "name": "smad3_mrna",
        "maps_to": "systemsbiology_sbml_proctor2017_role_of_micrornas_in_osteoarthritis_model1705170000_model.smad3_mrna"
      }
    ]
  },
  "tags": [
    "generegulation",
    "systemsbiology",
    "sbml",
    "biomodels_ebi",
    "faithful",
    "curated"
  ],
  "title": "Proctor2017 Role Of Micrornas In Osteoarthritis 8 Lab",
  "models": [
    {
      "path": "owned/models/systemsbiology_sbml_proctor2017_role_of_micrornas_in_osteoarthritis_model1705170000_model",
      "alias": "systemsbiology_sbml_proctor2017_role_of_micrornas_in_osteoarthritis_model1705170000_model",
      "provenance": {
        "owned_path": "owned/models/systemsbiology_sbml_proctor2017_role_of_micrornas_in_osteoarthritis_model1705170000_model"
      }
    },
    {
      "path": "owned/models/visualisation",
      "alias": "visualisation",
      "provenance": {
        "owned_path": "owned/models/visualisation"
      }
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.systemsbiology_sbml_proctor2017_role_of_micrornas_in_osteoarthritis_model1705170000_model_state"
      ],
      "from": "systemsbiology_sbml_proctor2017_role_of_micrornas_in_osteoarthritis_model1705170000_model.state"
    },
    {
      "to": [
        "visualisation.systemsbiology_sbml_proctor2017_role_of_micrornas_in_osteoarthritis_model1705170000_model_summary"
      ],
      "from": "systemsbiology_sbml_proctor2017_role_of_micrornas_in_osteoarthritis_model1705170000_model.summary"
    },
    {
      "to": [
        "visualisation.systemsbiology_sbml_proctor2017_role_of_micrornas_in_osteoarthritis_model1705170000_model_species_labels"
      ],
      "from": "systemsbiology_sbml_proctor2017_role_of_micrornas_in_osteoarthritis_model1705170000_model.species_labels"
    }
  ],
  "runtime": {
    "duration": 1,
    "initial_inputs": {},
    "communication_step": 0.1
  },
  "description": "Proctor2017- Role of microRNAs inosteoarthritis (miR140-SMAD3 double negative feedback) This model is described in the article: Computer simulation models as a tool to investigate the role of microRNA. It can be used to explore systemsbiology proctor2017 role of micrornas in dynamics and compare simulation behavior across conditions.",
  "schema_version": "2.0"
}

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