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Proctor2017- Role of microRNAs in osteoarthritis (miR140-SOX9 incoherent feed forward) This model is described in the article: Computer simulation models as a tool to investigate the role of microRNAs. It can be used to explore systemsbiology proctor2017 role of micrornas in dynamics and compare simulation behavior across conditions.
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Metadata
Packageproctor2017-role-of-micrornas-in-osteoarthritis-9-lab
Created2026-05-17
Updated2026-05-17
generegulationsystemsbiologysbmlbiomodels_ebifaithfulcuratedvisualisation
Manifest
{
"io": {
"inputs": [
{
"name": "initial_sox9",
"label": "Initial Sox9",
"maps_to": "systemsbiology_sbml_proctor2017_role_of_micrornas_in_osteoarthritis_model1705170003_model.initial_sox9",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `SOX9`."
},
{
"name": "initial_runx2",
"label": "Initial Runx2",
"maps_to": "systemsbiology_sbml_proctor2017_role_of_micrornas_in_osteoarthritis_model1705170003_model.initial_runx2",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `RUNX2`."
},
{
"name": "initial_hdac4",
"label": "Initial Hdac4",
"maps_to": "systemsbiology_sbml_proctor2017_role_of_micrornas_in_osteoarthritis_model1705170003_model.initial_hdac4",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `HDAC4`."
},
{
"name": "initial_mi_r140",
"label": "Initial Mi R140",
"maps_to": "systemsbiology_sbml_proctor2017_role_of_micrornas_in_osteoarthritis_model1705170003_model.initial_mi_r140",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `miR140`."
},
{
"name": "initial_hdac4_mrna",
"label": "Initial Hdac4 MRNA",
"maps_to": "systemsbiology_sbml_proctor2017_role_of_micrornas_in_osteoarthritis_model1705170003_model.initial_hdac4_mrna",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `HDAC4_mRNA`."
},
{
"name": "initial_runx2_gene",
"label": "Initial Runx2 Gene",
"maps_to": "systemsbiology_sbml_proctor2017_role_of_micrornas_in_osteoarthritis_model1705170003_model.initial_runx2_gene",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `RUNX2_gene`."
}
],
"outputs": [
{
"name": "state",
"maps_to": "systemsbiology_sbml_proctor2017_role_of_micrornas_in_osteoarthritis_model1705170003_model.state"
},
{
"name": "summary",
"maps_to": "systemsbiology_sbml_proctor2017_role_of_micrornas_in_osteoarthritis_model1705170003_model.summary"
},
{
"name": "species_labels",
"maps_to": "systemsbiology_sbml_proctor2017_role_of_micrornas_in_osteoarthritis_model1705170003_model.species_labels"
},
{
"name": "sox9",
"maps_to": "systemsbiology_sbml_proctor2017_role_of_micrornas_in_osteoarthritis_model1705170003_model.sox9"
},
{
"name": "runx2",
"maps_to": "systemsbiology_sbml_proctor2017_role_of_micrornas_in_osteoarthritis_model1705170003_model.runx2"
},
{
"name": "hdac4",
"maps_to": "systemsbiology_sbml_proctor2017_role_of_micrornas_in_osteoarthritis_model1705170003_model.hdac4"
},
{
"name": "mi_r140",
"maps_to": "systemsbiology_sbml_proctor2017_role_of_micrornas_in_osteoarthritis_model1705170003_model.mi_r140"
},
{
"name": "hdac4_mrna",
"maps_to": "systemsbiology_sbml_proctor2017_role_of_micrornas_in_osteoarthritis_model1705170003_model.hdac4_mrna"
},
{
"name": "runx2_gene",
"maps_to": "systemsbiology_sbml_proctor2017_role_of_micrornas_in_osteoarthritis_model1705170003_model.runx2_gene"
}
]
},
"tags": [
"generegulation",
"systemsbiology",
"sbml",
"biomodels_ebi",
"faithful",
"curated"
],
"title": "Proctor2017 Role Of Micrornas In Osteoarthritis 9 Lab",
"models": [
{
"path": "owned/models/systemsbiology_sbml_proctor2017_role_of_micrornas_in_osteoarthritis_model1705170003_model",
"alias": "systemsbiology_sbml_proctor2017_role_of_micrornas_in_osteoarthritis_model1705170003_model",
"provenance": {
"owned_path": "owned/models/systemsbiology_sbml_proctor2017_role_of_micrornas_in_osteoarthritis_model1705170003_model"
}
},
{
"path": "owned/models/visualisation",
"alias": "visualisation",
"provenance": {
"owned_path": "owned/models/visualisation"
}
}
],
"wiring": [
{
"to": [
"visualisation.systemsbiology_sbml_proctor2017_role_of_micrornas_in_osteoarthritis_model1705170003_model_state"
],
"from": "systemsbiology_sbml_proctor2017_role_of_micrornas_in_osteoarthritis_model1705170003_model.state"
},
{
"to": [
"visualisation.systemsbiology_sbml_proctor2017_role_of_micrornas_in_osteoarthritis_model1705170003_model_summary"
],
"from": "systemsbiology_sbml_proctor2017_role_of_micrornas_in_osteoarthritis_model1705170003_model.summary"
},
{
"to": [
"visualisation.systemsbiology_sbml_proctor2017_role_of_micrornas_in_osteoarthritis_model1705170003_model_species_labels"
],
"from": "systemsbiology_sbml_proctor2017_role_of_micrornas_in_osteoarthritis_model1705170003_model.species_labels"
}
],
"runtime": {
"duration": 1,
"initial_inputs": {},
"communication_step": 0.1
},
"description": "Proctor2017- Role of microRNAs in osteoarthritis (miR140-SOX9 incoherent feed forward) This model is described in the article: Computer simulation models as a tool to investigate the role of microRNAs. It can be used to explore systemsbiology proctor2017 role of micrornas in dynamics and compare simulation behavior across conditions.",
"schema_version": "2.0"
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