About lab
Heldt2002 Orthostatic Stress - Lumped Parameter Circulation Lab
This lab runs the Heldt et al. (2002) lumped-parameter circulation model. It asks: how do cardiac filling, aortic and pulmonary flow, mean arterial pressure, and the left-ventricular pressure-volume loop respond during a 60 s orthostatic-stress circulation run?
The model wraps the BioModels EBI SBML asset MODEL1006230113. The models/core package handles SBML execution and stable headline outputs, while models/visualisation owns grouped charts, phase portraits, and plain-language summaries.
What You'll See
The lab opens as a canvas with one Heldt2002 LPC node and a run-results panel. A default run produces grouped time-series panels for chamber volumes, aortic and pulmonary trunk volumes, pulmonary/systemic/coronary perfusion, flow waveforms, pressure waveforms, a largest-excursions diagnostic, a What Happened table, and an LV pressure-volume loop.
The first screenshot shows the canvas and top result panels for cardiac chamber volumes plus aortic and pulmonary trunk volumes. The second scrolls down to aortic/pulmonary flow waveforms and pressure waveforms. The third shows the What Happened table and the LV pressure-volume loop.
How to Read the Visualizations
The cardiac chamber plot shows left/right atrial and ventricular filling across repeated cardiac cycles. The aortic and pulmonary trunk plot separates proximal and distal vascular segments so you can compare how each segment fills and drains.
The flow and pressure panels are the main hemodynamic readouts. They show pulsatile aortic and pulmonary flow waveforms, plus mean arterial pressure and proximal aortic pressure across the same 60 s run.
The What Happened table summarizes the run without reading every trace. In the shown run, it reports 30 tracked rate-rule observables, systemic vein volume as both the largest signed change and largest peak, and no observable settling within 1% over the final 10% of the run.
The LV pressure-volume loop shows the last cardiac cycle as pressure against volume. Loop area corresponds to stroke work, x-extent to preload, and the upper pressure plateau to afterload.
What This Lab Contains
lab.yamldescribes the lab, runtime, inputs, outputs, and default model parameters.wiring-layout.jsonplaces the model on the canvas.models/core/model.yamldescribes the SBML execution package, upstream source, parameters, and ports.models/core/src/heldt2002_orthostaticstress_lpc.pywraps the SBML model and publishes stable numeric outputs.models/core/data/MODEL1006230113.xmlis the curated SBML model file from BioModels EBI.models/visualisation/contains the dedicated presentation model for grouped charts, summaries, and phase portraits.models/*/tests/contains smoke tests for core execution and visualisation behavior.
Inputs
heart_rate(1/min): cardiac pacing rate.peak_lv_elastance(mmHg/mL): peak left-ventricle elastance; higher values model stronger contractility.integration_step(s): output sampling step for the Tellurium simulator.
Outputs
cardiac_output: cycle-averaged cardiac output over the model's headline window.mean_arterial_pressure: cycle-averaged mean arterial pressure over the model's headline window.state: latest values of the tracked rate-rule observables.summary: final, peak, minimum, and largest-change diagnostics for the run.
Recreate and Run with the Biosim CLI
From this lab folder:
cd /path/to/models-biomechanics/labs/heldt2002-lpc
mkdir -p dist
python -m biosim pack build . --out dist/heldt2002-lpc.bsilab
python -m biosim pack run dist/heldt2002-lpc.bsilab
If you are working from this monorepo without installing biosim, use the local package environment instead:
mkdir -p dist
/path/to/bsim-active/biosim/.venv/bin/python -m biosim pack build . --out dist/heldt2002-lpc.bsilab
/path/to/bsim-active/biosim/.venv/bin/python -m biosim pack run dist/heldt2002-lpc.bsilab
Run in the Desktop App
- Open Biosimulant Desktop.
- Go to Projects or Labs.
- Choose the option to open or import an existing lab.
- Select this folder's
lab.yaml. - Open the lab and press Run.
The right side of the app should show grouped cardiovascular result panels, summary diagnostics, and the LV pressure-volume loop.
How to Edit It
For scenario changes, start with lab.yaml and models/core/model.yaml.
- Change
runtime.durationinlab.yamlfor a longer or shorter simulation. - Change
runtime.communication_stepif you want more or fewer reported points. - Change
heart_rateorpeak_lv_elastanceto perturb the circulation scenario. - Change
integration_stepinmodels/core/model.yamlfor finer or coarser Tellurium output sampling.
To change the physiology itself, edit or replace models/core/data/MODEL1006230113.xml. Edit models/core/src/heldt2002_orthostaticstress_lpc.py only if you are changing execution behavior or published numeric outputs; edit models/visualisation/ for labels, grouping, prose, and charts.
Heldt et al. (2002) lumped-parameter circulation (LPC) model tracking aortic pressure, mean arterial pressure, and aortic flow under orthostatic stress.
Runtime
Duration60
Comms Step1
Runs
Total6
Completed6
Failed0
Metadata
Packageheldt2002-orthostatic-stress---lumped-parameter-circulation-lab
Created2026-05-04
Updated2026-05-04
Manifest
{
"description": "Heldt et al. (2002) lumped-parameter circulation (LPC) model tracking aortic pressure, mean arterial pressure, and aortic flow under orthostatic stress.",
"io": {
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{
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"name": "heart_rate"
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{
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},
{
"maps_to": "heldt2002_orthostaticstress_lpc.peak_lv_elastance",
"name": "peak_lv_elastance"
}
],
"outputs": [
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"name": "cardiac_output"
},
{
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"name": "mean_arterial_pressure"
},
{
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{
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},
"path": "owned/models/heldt2002_orthostaticstress_lpc",
"provenance": {
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{
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"runtime": {
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"duration": 60,
"initial_inputs": {}
},
"schema_version": "2.0",
"title": "Heldt2002 Orthostatic Stress - Lumped Parameter Circulation Lab",
"wiring": [
{
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"to": [
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},
{
"from": "heldt2002_orthostaticstress_lpc.mean_arterial_pressure",
"to": [
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},
{
"from": "heldt2002_orthostaticstress_lpc.state",
"to": [
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},
{
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"to": [
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},
{
"from": "heldt2002_orthostaticstress_lpc.visualisation_aux",
"to": [
"visualisation.heldt2002_orthostaticstress_lpc_visualisation_aux"
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}
]
}Sign in to start your own run. Public-lab history stays visible here.
Logs
No logs yet.
JSON
{
"communication_step": 1,
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{
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"status": "reused"
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],
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"model_resolutions": [
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"title": "Heldt2002 Orthostatic Stress - Lumped Parameter Circulation - Other observables",
"x_unit": "s"
},
"description": "How do the remaining observed variables evolve over time?",
"render": "timeseries"
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"Pulmonary vein volume",
"Systemic capillary volume",
"Right ventricle volume",
"Left ventricle volume",
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"title": "Heldt2002 Orthostatic Stress - Lumped Parameter Circulation - largest excursions during the run",
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"60 s"
],
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"Systemic vein volume (-566)"
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"No observable settled within 1% over the last 10% of the run."
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"title": "What Happened"
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}