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Al-Husari2013 - pH and lactate in tumor Lab

About lab

The paper describes a model of pH control in tumor. Created by COPASI 4.26 (Build 213) This model is described in the article: Regulation of tumour intracellular pH: A mathematical model examining the.

Runtime

Duration10
Comms Step1

Runs

Total0
Completed0
Failed0

Metadata

Packageal-husari2013-ph-and-lactate-in-tumor-lab
Created2026-05-16
Updated2026-05-16
biomodels_ebicuratedfaithfulmetabolismoncologyphysiologysbmlsystemsbiologytumor-growthvisualisation

Manifest

{
  "io": {
    "inputs": [
      {
        "name": "intracellular_ph",
        "label": "Intracellular pH",
        "units": "native SBML value",
        "default": 7.3,
        "maps_to": "oncology_sbml_al_husari2013_ph_and_lactate_in_tumor_biomd0000000805_model.intracellular_ph",
        "description": "Intracellular pH. Overrides bundled SBML parameter `pHi`."
      },
      {
        "name": "extracellular_ph",
        "label": "Extracellular pH",
        "units": "native SBML value",
        "default": 7,
        "maps_to": "oncology_sbml_al_husari2013_ph_and_lactate_in_tumor_biomd0000000805_model.extracellular_ph",
        "description": "Extracellular pH. Overrides bundled SBML parameter `pHe`."
      }
    ],
    "outputs": [
      {
        "name": "intracellular_hydrogen_ion",
        "maps_to": "oncology_sbml_al_husari2013_ph_and_lactate_in_tumor_biomd0000000805_model.intracellular_hydrogen_ion",
        "description": "Intracellular Hydrogen Ion observable. Maps to SBML symbol `Hi`."
      },
      {
        "name": "extracellular_hydrogen_ion",
        "maps_to": "oncology_sbml_al_husari2013_ph_and_lactate_in_tumor_biomd0000000805_model.extracellular_hydrogen_ion",
        "description": "Extracellular Hydrogen Ion observable. Maps to SBML symbol `He`."
      },
      {
        "name": "intracellular_lactate",
        "maps_to": "oncology_sbml_al_husari2013_ph_and_lactate_in_tumor_biomd0000000805_model.intracellular_lactate",
        "description": "Intracellular Lactate observable. Maps to SBML symbol `Li`."
      },
      {
        "name": "extracellular_lactate",
        "maps_to": "oncology_sbml_al_husari2013_ph_and_lactate_in_tumor_biomd0000000805_model.extracellular_lactate",
        "description": "Extracellular Lactate observable. Maps to SBML symbol `Le`."
      },
      {
        "name": "state",
        "maps_to": "oncology_sbml_al_husari2013_ph_and_lactate_in_tumor_biomd0000000805_model.state",
        "description": "Full raw SBML observable record for reproducibility and downstream visualisation."
      },
      {
        "name": "summary",
        "maps_to": "oncology_sbml_al_husari2013_ph_and_lactate_in_tumor_biomd0000000805_model.summary",
        "description": "Change and peak summary across the simulated SBML observables."
      },
      {
        "name": "species_labels",
        "maps_to": "oncology_sbml_al_husari2013_ph_and_lactate_in_tumor_biomd0000000805_model.species_labels",
        "description": "Mapping from selected raw SBML observable symbols to display labels."
      }
    ]
  },
  "tags": [
    "biomodels_ebi",
    "curated",
    "faithful",
    "metabolism",
    "oncology",
    "physiology",
    "sbml",
    "systemsbiology",
    "tumor-growth"
  ],
  "title": "Al-Husari2013 - pH and lactate in tumor Lab",
  "models": [
    {
      "path": "owned/models/oncology_sbml_al_husari2013_ph_and_lactate_in_tumor_biomd0000000805_model",
      "alias": "oncology_sbml_al_husari2013_ph_and_lactate_in_tumor_biomd0000000805_model",
      "provenance": {
        "owned_path": "owned/models/oncology_sbml_al_husari2013_ph_and_lactate_in_tumor_biomd0000000805_model"
      }
    },
    {
      "path": "owned/models/visualisation",
      "alias": "visualisation",
      "provenance": {
        "owned_path": "owned/models/visualisation"
      }
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.oncology_sbml_al_husari2013_ph_and_lactate_in_tumor_biomd0000000805_model_state"
      ],
      "from": "oncology_sbml_al_husari2013_ph_and_lactate_in_tumor_biomd0000000805_model.state"
    },
    {
      "to": [
        "visualisation.oncology_sbml_al_husari2013_ph_and_lactate_in_tumor_biomd0000000805_model_summary"
      ],
      "from": "oncology_sbml_al_husari2013_ph_and_lactate_in_tumor_biomd0000000805_model.summary"
    },
    {
      "to": [
        "visualisation.oncology_sbml_al_husari2013_ph_and_lactate_in_tumor_biomd0000000805_model_species_labels"
      ],
      "from": "oncology_sbml_al_husari2013_ph_and_lactate_in_tumor_biomd0000000805_model.species_labels"
    }
  ],
  "runtime": {
    "duration": 10,
    "initial_inputs": {},
    "communication_step": 1
  },
  "description": "The paper describes a model of pH control in tumor. Created by COPASI 4.26 (Build 213) This model is described in the article: Regulation of tumour intracellular pH: A mathematical model examining the.",
  "schema_version": "2.0"
}

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