Schropp2019 - Target-Mediated Drug Disposition Model for Bispecific Antibodies Lab

{
  "io": {
    "inputs": [
      {
        "name": "initial_free_bispecific_antibody",
        "label": "Initial Free Bispecific Antibody",
        "maps_to": "pharmacology_sbml_schropp2019_target_mediated_drug_disposition_mod_biomd0000000788_model.initial_free_bispecific_antibody"
      },
      {
        "name": "initial_target_a_concentration",
        "label": "Initial Target A Concentration",
        "maps_to": "pharmacology_sbml_schropp2019_target_mediated_drug_disposition_mod_biomd0000000788_model.initial_target_a_concentration"
      },
      {
        "name": "initial_target_b_concentration",
        "label": "Initial Target B Concentration",
        "maps_to": "pharmacology_sbml_schropp2019_target_mediated_drug_disposition_mod_biomd0000000788_model.initial_target_b_concentration"
      },
      {
        "name": "target_a_association_rate",
        "label": "Target A Association Rate",
        "maps_to": "pharmacology_sbml_schropp2019_target_mediated_drug_disposition_mod_biomd0000000788_model.target_a_association_rate"
      },
      {
        "name": "target_b_association_rate",
        "label": "Target B Association Rate",
        "maps_to": "pharmacology_sbml_schropp2019_target_mediated_drug_disposition_mod_biomd0000000788_model.target_b_association_rate"
      },
      {
        "name": "central_elimination_rate",
        "label": "Central Elimination Rate",
        "maps_to": "pharmacology_sbml_schropp2019_target_mediated_drug_disposition_mod_biomd0000000788_model.central_elimination_rate"
      }
    ],
    "outputs": [
      {
        "name": "state",
        "label": "Tracked source state",
        "maps_to": "pharmacology_sbml_schropp2019_target_mediated_drug_disposition_mod_biomd0000000788_model.state"
      },
      {
        "name": "summary",
        "label": "Simulation summary",
        "maps_to": "pharmacology_sbml_schropp2019_target_mediated_drug_disposition_mod_biomd0000000788_model.summary"
      },
      {
        "name": "species_labels",
        "label": "Observable labels",
        "maps_to": "pharmacology_sbml_schropp2019_target_mediated_drug_disposition_mod_biomd0000000788_model.species_labels"
      },
      {
        "name": "free_bispecific_antibody",
        "label": "Free Bispecific Antibody",
        "maps_to": "pharmacology_sbml_schropp2019_target_mediated_drug_disposition_mod_biomd0000000788_model.free_bispecific_antibody"
      },
      {
        "name": "free_target_a",
        "label": "Free Target A",
        "maps_to": "pharmacology_sbml_schropp2019_target_mediated_drug_disposition_mod_biomd0000000788_model.free_target_a"
      },
      {
        "name": "free_target_b",
        "label": "Free Target B",
        "maps_to": "pharmacology_sbml_schropp2019_target_mediated_drug_disposition_mod_biomd0000000788_model.free_target_b"
      },
      {
        "name": "antibody_target_a_complex",
        "label": "Antibody Target A Complex",
        "maps_to": "pharmacology_sbml_schropp2019_target_mediated_drug_disposition_mod_biomd0000000788_model.antibody_target_a_complex"
      },
      {
        "name": "antibody_target_b_complex",
        "label": "Antibody Target B Complex",
        "maps_to": "pharmacology_sbml_schropp2019_target_mediated_drug_disposition_mod_biomd0000000788_model.antibody_target_b_complex"
      },
      {
        "name": "bispecific_bridge_complex",
        "label": "Bispecific Bridge Complex",
        "maps_to": "pharmacology_sbml_schropp2019_target_mediated_drug_disposition_mod_biomd0000000788_model.bispecific_bridge_complex"
      },
      {
        "name": "peripheral_antibody",
        "label": "Peripheral Antibody",
        "maps_to": "pharmacology_sbml_schropp2019_target_mediated_drug_disposition_mod_biomd0000000788_model.peripheral_antibody"
      },
      {
        "name": "depot_antibody",
        "label": "Depot Antibody",
        "maps_to": "pharmacology_sbml_schropp2019_target_mediated_drug_disposition_mod_biomd0000000788_model.depot_antibody"
      }
    ]
  },
  "tags": [
    "pharmacology",
    "pharmacokinetics",
    "tmdd",
    "biologics",
    "immunology",
    "sbml",
    "tellurium",
    "faithful",
    "biomodels_ebi"
  ],
  "title": "Schropp2019 - Target-Mediated Drug Disposition Model for Bispecific Antibodies Lab",
  "models": [
    {
      "path": "models/core",
      "alias": "pharmacology_sbml_schropp2019_target_mediated_drug_disposition_mod_biomd0000000788_model",
      "parameters": {
        "model_path": "data/BIOMD0000000788.xml",
        "integration_step": 0.1
      }
    },
    {
      "path": "models/visualisation",
      "alias": "visualisation"
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.pharmacology_sbml_schropp2019_target_mediated_drug_disposition_mod_biomd0000000788_model_state"
      ],
      "from": "pharmacology_sbml_schropp2019_target_mediated_drug_disposition_mod_biomd0000000788_model.state"
    },
    {
      "to": [
        "visualisation.pharmacology_sbml_schropp2019_target_mediated_drug_disposition_mod_biomd0000000788_model_summary"
      ],
      "from": "pharmacology_sbml_schropp2019_target_mediated_drug_disposition_mod_biomd0000000788_model.summary"
    },
    {
      "to": [
        "visualisation.pharmacology_sbml_schropp2019_target_mediated_drug_disposition_mod_biomd0000000788_model_species_labels"
      ],
      "from": "pharmacology_sbml_schropp2019_target_mediated_drug_disposition_mod_biomd0000000788_model.species_labels"
    }
  ],
  "package": "schropp2019-bispecific-antibody-tmdd",
  "runtime": {
    "duration": 24,
    "initial_inputs": {},
    "communication_step": 1
  },
  "version": "1.0.0",
  "description": "This model presents a general target-mediated drug disposition (TMDD) model for bispecific antibodies (BsAbs), which bind to two different targets on different cell membranes. It can be used to explore dose-response dynamics and compare treatment scenarios across conditions.",
  "schema_version": "2.0"
}