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BIOMD0000000643 Variant Musante2017 Switching Behaviour Of Pp2a Inhibition By Arpp 16 Mutual I Lab

About lab

Musante2017 Switching Behaviour Of Pp2a Inhibition By Arpp 16 Mutual I (BIOMD0000000643)

This Biosimulant lab wraps BIOMD0000000643 Musante2017 Switching Behaviour Of Pp2a Inhibition By Arpp 16 Mutual I as a runnable systems biology model with a companion visualization module. Musante2017 - Switching behaviour of PP2Ainhibition by ARPP-16 - mutual inhibitions This model is described in the article: Reciprocal regulation of ARPP-16 by PKA and MAST3 kinases provides a cAMP-re. It can be used to explore the configured dynamics and compare scenario outcomes across configurations.

What You'll See

The lab asks: Which source-defined system states dominate this SBML model trajectory? Source model: Musante2017 - Switching behaviour of PP2A inhibition by ARPP-16 - mutual inhibitions. It runs for 1.0 time units with a communication step of 0.1. The run uses the model defaults declared by the curated SBML wrapper. The generated visualizations focus on BB, A46, Complex, A88, PKA, and M, combining trajectory, endpoint-comparison, and summary-table views from one completed dark-mode run.

In this captured run, A88 moved from 0.2000 to 0.0251 across 1.0 simulation windows.

Output Visualizations

Musante2017 Switching Behaviour Of Pp2a Inhibition By Arpp 16 Mutual I - run interpretation

Summary table for Musante2017 Switching Behaviour Of Pp2a Inhibition By Arpp 16 Mutual I, reporting the scientific question, observed answer, dominant module, and caveat.

Musante2017 Switching Behaviour Of Pp2a Inhibition By Arpp 16 Mutual I - timeseries visualization

Trajectories of A88, M, BB, A46, Complex, and PKA across the 1.0 simulation. In this run M climbed from 0 to 0.1187 and A88 fell from 0.2000 to 0.0251 — the largest movements among the focused observables.

Musante2017 Switching Behaviour Of Pp2a Inhibition By Arpp 16 Mutual I - excursions bar

Largest-excursion ranking of the focused observables — the absolute movement magnitude during the run. Top 3: A88 = 0.1749, M = 0.1187, BB = 0.0859, with 2 more observables below.

Musante2017 Switching Behaviour Of Pp2a Inhibition By Arpp 16 Mutual I - endpoint snapshot bar

Endpoint snapshot of the focused observables — final values from the captured run. Top 3 by value: BB = 11.730, A46 = 9.714, Complex = 1.996, with 2 more observables below.

Musante2017 Switching Behaviour Of Pp2a Inhibition By Arpp 16 Mutual I - visualization

Visualization card from the Musante2017 Switching Behaviour Of Pp2a Inhibition By Arpp 16 Mutual I dark-mode run.

Model Context

  • Core model: models/core
  • Visualization model: models/visualisation
  • Standard: other
  • Upstream source: biomodels_ebi:BIOMD0000000643
  • License: CC0

Inputs

InputMaps ToDefaultNotes
Initial Model State Bbsystemsbiology_sbml_musante2017_switching_behaviour_of_pp2a_inhibiti_biomd0000000643_model.initial_model_state_bbSource state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol BB.
Initial Model State A46systemsbiology_sbml_musante2017_switching_behaviour_of_pp2a_inhibiti_biomd0000000643_model.initial_model_state_a46Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol A46.
Initial Complexsystemsbiology_sbml_musante2017_switching_behaviour_of_pp2a_inhibiti_biomd0000000643_model.initial_complexSource state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol Complex.
Initial Model State A88systemsbiology_sbml_musante2017_switching_behaviour_of_pp2a_inhibiti_biomd0000000643_model.initial_model_state_a88Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol A88.
Initial Model State Pkasystemsbiology_sbml_musante2017_switching_behaviour_of_pp2a_inhibiti_biomd0000000643_model.initial_model_state_pkaSource state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol PKA.
Initial Model State Msystemsbiology_sbml_musante2017_switching_behaviour_of_pp2a_inhibiti_biomd0000000643_model.initial_model_state_mSource state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol M.

Outputs

OutputMaps ToRole
statesystemsbiology_sbml_musante2017_switching_behaviour_of_pp2a_inhibiti_biomd0000000643_model.stateAvailable to the visualization model and downstream workflows.
summarysystemsbiology_sbml_musante2017_switching_behaviour_of_pp2a_inhibiti_biomd0000000643_model.summaryAvailable to the visualization model and downstream workflows.
species_labelssystemsbiology_sbml_musante2017_switching_behaviour_of_pp2a_inhibiti_biomd0000000643_model.species_labelsAvailable to the visualization model and downstream workflows.
model_state_bbsystemsbiology_sbml_musante2017_switching_behaviour_of_pp2a_inhibiti_biomd0000000643_model.model_state_bbAvailable to the visualization model and downstream workflows.
a46systemsbiology_sbml_musante2017_switching_behaviour_of_pp2a_inhibiti_biomd0000000643_model.a46Available to the visualization model and downstream workflows.
complexsystemsbiology_sbml_musante2017_switching_behaviour_of_pp2a_inhibiti_biomd0000000643_model.complexAvailable to the visualization model and downstream workflows.
a88systemsbiology_sbml_musante2017_switching_behaviour_of_pp2a_inhibiti_biomd0000000643_model.a88Available to the visualization model and downstream workflows.
pkasystemsbiology_sbml_musante2017_switching_behaviour_of_pp2a_inhibiti_biomd0000000643_model.pkaAvailable to the visualization model and downstream workflows.
model_state_msystemsbiology_sbml_musante2017_switching_behaviour_of_pp2a_inhibiti_biomd0000000643_model.model_state_mAvailable to the visualization model and downstream workflows.

Runtime

  • Duration: 1.0
  • Communication step: 0.1

Running Locally

biosimulant labs serve

Musante2017 - Switching behaviour of PP2Ainhibition by ARPP-16 - mutual inhibitions This model is described in the article: Reciprocal regulation of ARPP-16 by PKA and MAST3 kinases provides a cAMP-re. It can be used to explore systemsbiology musante2017 switching behaviour of pp2a dynamics and compare simulation behavior across conditions.

Runtime

Duration1
Comms Step0.1

Runs

Total0
Completed0
Failed0

Metadata

Packagebiomd0000000643-musante2017-switching-behaviour-of-pp2a-inhibiti
Created2026-05-17
Updated2026-05-17
systemsbiologysbmlbiomodels_ebifaithfulcuratedvisualisation

Manifest

{
  "io": {
    "inputs": [
      {
        "name": "initial_model_state_bb",
        "label": "Initial Model State Bb",
        "maps_to": "systemsbiology_sbml_musante2017_switching_behaviour_of_pp2a_inhibiti_biomd0000000643_model.initial_model_state_bb",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `BB`."
      },
      {
        "name": "initial_model_state_a46",
        "label": "Initial Model State A46",
        "maps_to": "systemsbiology_sbml_musante2017_switching_behaviour_of_pp2a_inhibiti_biomd0000000643_model.initial_model_state_a46",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `A46`."
      },
      {
        "name": "initial_complex",
        "label": "Initial Complex",
        "maps_to": "systemsbiology_sbml_musante2017_switching_behaviour_of_pp2a_inhibiti_biomd0000000643_model.initial_complex",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `Complex`."
      },
      {
        "name": "initial_model_state_a88",
        "label": "Initial Model State A88",
        "maps_to": "systemsbiology_sbml_musante2017_switching_behaviour_of_pp2a_inhibiti_biomd0000000643_model.initial_model_state_a88",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `A88`."
      },
      {
        "name": "initial_model_state_pka",
        "label": "Initial Model State Pka",
        "maps_to": "systemsbiology_sbml_musante2017_switching_behaviour_of_pp2a_inhibiti_biomd0000000643_model.initial_model_state_pka",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `PKA`."
      },
      {
        "name": "initial_model_state_m",
        "label": "Initial Model State M",
        "maps_to": "systemsbiology_sbml_musante2017_switching_behaviour_of_pp2a_inhibiti_biomd0000000643_model.initial_model_state_m",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `M`."
      }
    ],
    "outputs": [
      {
        "name": "state",
        "maps_to": "systemsbiology_sbml_musante2017_switching_behaviour_of_pp2a_inhibiti_biomd0000000643_model.state"
      },
      {
        "name": "summary",
        "maps_to": "systemsbiology_sbml_musante2017_switching_behaviour_of_pp2a_inhibiti_biomd0000000643_model.summary"
      },
      {
        "name": "species_labels",
        "maps_to": "systemsbiology_sbml_musante2017_switching_behaviour_of_pp2a_inhibiti_biomd0000000643_model.species_labels"
      },
      {
        "name": "model_state_bb",
        "maps_to": "systemsbiology_sbml_musante2017_switching_behaviour_of_pp2a_inhibiti_biomd0000000643_model.model_state_bb"
      },
      {
        "name": "a46",
        "maps_to": "systemsbiology_sbml_musante2017_switching_behaviour_of_pp2a_inhibiti_biomd0000000643_model.a46"
      },
      {
        "name": "complex",
        "maps_to": "systemsbiology_sbml_musante2017_switching_behaviour_of_pp2a_inhibiti_biomd0000000643_model.complex"
      },
      {
        "name": "a88",
        "maps_to": "systemsbiology_sbml_musante2017_switching_behaviour_of_pp2a_inhibiti_biomd0000000643_model.a88"
      },
      {
        "name": "pka",
        "maps_to": "systemsbiology_sbml_musante2017_switching_behaviour_of_pp2a_inhibiti_biomd0000000643_model.pka"
      },
      {
        "name": "model_state_m",
        "maps_to": "systemsbiology_sbml_musante2017_switching_behaviour_of_pp2a_inhibiti_biomd0000000643_model.model_state_m"
      }
    ]
  },
  "tags": [
    "systemsbiology",
    "sbml",
    "biomodels_ebi",
    "faithful",
    "curated"
  ],
  "title": "BIOMD0000000643 Variant Musante2017 Switching Behaviour Of Pp2a Inhibition By Arpp 16 Mutual I Lab",
  "models": [
    {
      "path": "owned/models/systemsbiology_sbml_musante2017_switching_behaviour_of_pp2a_inhibiti_biomd0000000643_model",
      "alias": "systemsbiology_sbml_musante2017_switching_behaviour_of_pp2a_inhibiti_biomd0000000643_model",
      "provenance": {
        "owned_path": "owned/models/systemsbiology_sbml_musante2017_switching_behaviour_of_pp2a_inhibiti_biomd0000000643_model"
      }
    },
    {
      "path": "owned/models/visualisation",
      "alias": "visualisation",
      "provenance": {
        "owned_path": "owned/models/visualisation"
      }
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.systemsbiology_sbml_musante2017_switching_behaviour_of_pp2a_inhibiti_biomd0000000643_model_state"
      ],
      "from": "systemsbiology_sbml_musante2017_switching_behaviour_of_pp2a_inhibiti_biomd0000000643_model.state"
    },
    {
      "to": [
        "visualisation.systemsbiology_sbml_musante2017_switching_behaviour_of_pp2a_inhibiti_biomd0000000643_model_summary"
      ],
      "from": "systemsbiology_sbml_musante2017_switching_behaviour_of_pp2a_inhibiti_biomd0000000643_model.summary"
    },
    {
      "to": [
        "visualisation.systemsbiology_sbml_musante2017_switching_behaviour_of_pp2a_inhibiti_biomd0000000643_model_species_labels"
      ],
      "from": "systemsbiology_sbml_musante2017_switching_behaviour_of_pp2a_inhibiti_biomd0000000643_model.species_labels"
    }
  ],
  "runtime": {
    "duration": 1,
    "initial_inputs": {},
    "communication_step": 0.1
  },
  "description": "Musante2017 - Switching behaviour of PP2Ainhibition by ARPP-16 - mutual inhibitions This model is described in the article: Reciprocal regulation of ARPP-16 by PKA and MAST3 kinases provides a cAMP-re. It can be used to explore systemsbiology musante2017 switching behaviour of pp2a dynamics and compare simulation behavior across conditions.",
  "schema_version": "2.0"
}

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