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Leber2016 - Host immune response - H.pylori infection Lab

About lab

The model is first model of tissue level cellular immune responses to H. pylori in the publication, 'Modeling the role of lanthionine synthetase C-like 2 (LANCL2) in the modulation of immune responses.

Runtime

Duration10
Comms Step1

Runs

Total0
Completed0
Failed0

Metadata

Packageleber2016-host-immune-response-h-pylori-infection-lab
Created2026-05-15
Updated2026-05-15
immunologysbmlbiomodels_ebifaithfulcuratedvisualisation

Manifest

{
  "io": {
    "inputs": [
      {
        "name": "initial_interferon_gamma",
        "label": "Initial Interferon Gamma",
        "units": "native source value",
        "default": 10000,
        "maps_to": "immunology_sbml_leber2016_host_immune_response_h_pylori_infectio_model1611160002_model.initial_interferon_gamma",
        "description": "Initial Interferon Gamma. Sets the initial value of bundled SBML species `s142`."
      },
      {
        "name": "initial_unresolved_infection_observable_1",
        "label": "Initial Unresolved Infection Observable 1",
        "units": "native source value",
        "default": 100000000,
        "maps_to": "immunology_sbml_leber2016_host_immune_response_h_pylori_infectio_model1611160002_model.initial_unresolved_infection_observable_1",
        "description": "Initial Unresolved Infection Observable 1. Sets the initial value of bundled SBML species `s1`."
      },
      {
        "name": "initial_hplumdead",
        "label": "Initial Hplumdead",
        "units": "native source value",
        "default": 0,
        "maps_to": "immunology_sbml_leber2016_host_immune_response_h_pylori_infectio_model1611160002_model.initial_hplumdead",
        "description": "Initial Hplumdead. Sets the initial value of bundled SBML species `s47`."
      },
      {
        "name": "initial_tolb_signaling_component",
        "label": "Initial Tolb Signaling Component",
        "units": "native source value",
        "default": 0,
        "maps_to": "immunology_sbml_leber2016_host_immune_response_h_pylori_infectio_model1611160002_model.initial_tolb_signaling_component",
        "description": "Initial Tolb Signaling Component. Sets the initial value of bundled SBML species `s82`."
      }
    ],
    "outputs": [
      {
        "name": "interferon_gamma",
        "maps_to": "immunology_sbml_leber2016_host_immune_response_h_pylori_infectio_model1611160002_model.interferon_gamma"
      },
      {
        "name": "unresolved_infection_observable_1",
        "maps_to": "immunology_sbml_leber2016_host_immune_response_h_pylori_infectio_model1611160002_model.unresolved_infection_observable_1"
      },
      {
        "name": "hplumdead",
        "maps_to": "immunology_sbml_leber2016_host_immune_response_h_pylori_infectio_model1611160002_model.hplumdead"
      },
      {
        "name": "tolb_signaling_component",
        "maps_to": "immunology_sbml_leber2016_host_immune_response_h_pylori_infectio_model1611160002_model.tolb_signaling_component"
      },
      {
        "name": "total_t",
        "maps_to": "immunology_sbml_leber2016_host_immune_response_h_pylori_infectio_model1611160002_model.total_t"
      },
      {
        "name": "state",
        "maps_to": "immunology_sbml_leber2016_host_immune_response_h_pylori_infectio_model1611160002_model.state"
      },
      {
        "name": "summary",
        "maps_to": "immunology_sbml_leber2016_host_immune_response_h_pylori_infectio_model1611160002_model.summary"
      },
      {
        "name": "species_labels",
        "maps_to": "immunology_sbml_leber2016_host_immune_response_h_pylori_infectio_model1611160002_model.species_labels"
      }
    ]
  },
  "title": "Leber2016 - Host immune response - H.pylori infection Lab",
  "models": [
    {
      "path": "owned/models/immunology_sbml_leber2016_host_immune_response_h_pylori_infectio_model1611160002_model",
      "alias": "immunology_sbml_leber2016_host_immune_response_h_pylori_infectio_model1611160002_model",
      "provenance": {
        "owned_path": "owned/models/immunology_sbml_leber2016_host_immune_response_h_pylori_infectio_model1611160002_model"
      }
    },
    {
      "path": "owned/models/visualisation",
      "alias": "visualisation",
      "provenance": {
        "owned_path": "owned/models/visualisation"
      }
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.immunology_sbml_leber2016_host_immune_response_h_pylori_infectio_model1611160002_model_state"
      ],
      "from": "immunology_sbml_leber2016_host_immune_response_h_pylori_infectio_model1611160002_model.state"
    },
    {
      "to": [
        "visualisation.immunology_sbml_leber2016_host_immune_response_h_pylori_infectio_model1611160002_model_summary"
      ],
      "from": "immunology_sbml_leber2016_host_immune_response_h_pylori_infectio_model1611160002_model.summary"
    },
    {
      "to": [
        "visualisation.immunology_sbml_leber2016_host_immune_response_h_pylori_infectio_model1611160002_model_species_labels"
      ],
      "from": "immunology_sbml_leber2016_host_immune_response_h_pylori_infectio_model1611160002_model.species_labels"
    }
  ],
  "runtime": {
    "duration": 10,
    "initial_inputs": {},
    "communication_step": 1
  },
  "description": "The model is first model of tissue level cellular immune responses to H. pylori in the publication, 'Modeling the role of lanthionine synthetase C-like 2 (LANCL2) in the modulation of immune responses.",
  "schema_version": "2.0"
}

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