Wanant2000_InsulinReceptorModel_A Lab

About lab

Wanant2000_InsulinReceptorModel_A

This Biosimulant lab wraps Wanant2000_InsulinReceptorModel_A as a runnable signaling model with a companion visualization module. Clean Biosimulant lab for metabolic and hormone-linked signaling. It can be used to explore second-messenger and pathway-signaling dynamics and compare scenario outcomes across configurations.

What You'll See

The lab asks: How does Wanant2000 InsulinReceptorModel A route receptor activity into cAMP/PKA-linked readouts? It runs for 1.0 time units with a communication step of 0.1. The run uses the model defaults declared by the curated SBML wrapper. The generated visualizations focus on Source Defined X1 State, Source Defined X2 State, Source Defined X3 State, and Source Defined X4 State, combining trajectory, endpoint-comparison, and summary-table views from one completed dark-mode run.

In this captured run, Source Defined X1 State moved from 1000.0 to 999.8 across 1.0 simulation windows.

Output Visualizations

Wanant2000_InsulinReceptorModel_A - run interpretation

Summary table for Wanant2000_InsulinReceptorModel_A, reporting the scientific question, observed answer, dominant module, and caveat.

Wanant2000_InsulinReceptorModel_A - timeseries visualization

Trajectories of Source Defined X1 State, Source Defined X2 State, Source Defined X4 State, and Source Defined X3 State across the 1.0 simulation. In this run Source Defined X4 State climbed from 0 to 0.1000 and Source Defined X1 State fell from 1000.0 to 999.8 — the largest movements among the focused observables.

Wanant2000_InsulinReceptorModel_A - excursions bar

Largest-excursion ranking of the focused observables — the absolute movement magnitude during the run. Top 3: Source Defined X1 State = 999.8, Source Defined X4 State = 0.1000, Source Defined X3 State = 4e-12, with 1 more observable below.

Model Context

Core model: models/core
Visualization model: models/visualisation
Standard: other
Upstream source: biomodels_ebi:MODEL1201140005
License: CC0
Visual scope: GPCR and cAMP/PKA signaling
Caveat: Values are native SBML quantities; equations, parameters, units, and initial values remain in the bundled source file.

Inputs

Input	Maps To	Default	Notes
Initial source-defined X1 state	`signaling_sbml_wanant2000_insulinreceptormodel_a_model1201140005_model.initial_source_defined_x1_state`		Initial level of source-defined X1 state. Maps to SBML symbol `x1`; exposed as a traceable initial-condition perturbation.

Outputs

Output	Maps To	Role
`source_defined_x1_state`	`signaling_sbml_wanant2000_insulinreceptormodel_a_model1201140005_model.source_defined_x1_state`	source-defined X1 state.
`source_defined_x2_state`	`signaling_sbml_wanant2000_insulinreceptormodel_a_model1201140005_model.source_defined_x2_state`	source-defined X2 state.
`source_defined_x3_state`	`signaling_sbml_wanant2000_insulinreceptormodel_a_model1201140005_model.source_defined_x3_state`	source-defined X3 state.
`state`	`signaling_sbml_wanant2000_insulinreceptormodel_a_model1201140005_model.state`	Available to the visualization model and downstream workflows.
`summary`	`signaling_sbml_wanant2000_insulinreceptormodel_a_model1201140005_model.summary`	Available to the visualization model and downstream workflows.
`species_labels`	`signaling_sbml_wanant2000_insulinreceptormodel_a_model1201140005_model.species_labels`	Available to the visualization model and downstream workflows.

Runtime

Duration: 1.0
Communication step: 0.1

Running Locally

biosimulant labs serve .

Clean Biosimulant lab for metabolic and hormone-linked signaling. Values are native SBML quantities; equations, parameters, and initial values remain in the bundled source file.

Runtime

Duration1

Comms Step0.1

Runs

Total0

Completed0

Failed0

Metadata

Packagewanant2000-insulinreceptormodel-a-lab

Created2026-05-16

Updated2026-05-16

signalingsystemssystems-biologysbmlfaithfulbiomodels_ebigpcrmetabolic-signalinghormone-signalingvisualisation

Manifest

{
  "io": {
    "inputs": [
      {
        "name": "initial_source_defined_x1_state",
        "label": "Initial source-defined X1 state",
        "maps_to": "signaling_sbml_wanant2000_insulinreceptormodel_a_model1201140005_model.initial_source_defined_x1_state",
        "description": "Initial level of source-defined X1 state. Maps to SBML symbol `x1`; exposed as a traceable initial-condition perturbation."
      }
    ],
    "outputs": [
      {
        "name": "source_defined_x1_state",
        "label": "source-defined X1 state",
        "maps_to": "signaling_sbml_wanant2000_insulinreceptormodel_a_model1201140005_model.source_defined_x1_state",
        "description": "source-defined X1 state. Maps to SBML symbol `x1` and is emitted in native SBML units."
      },
      {
        "name": "source_defined_x2_state",
        "label": "source-defined X2 state",
        "maps_to": "signaling_sbml_wanant2000_insulinreceptormodel_a_model1201140005_model.source_defined_x2_state",
        "description": "source-defined X2 state. Maps to SBML symbol `x2` and is emitted in native SBML units."
      },
      {
        "name": "source_defined_x3_state",
        "label": "source-defined X3 state",
        "maps_to": "signaling_sbml_wanant2000_insulinreceptormodel_a_model1201140005_model.source_defined_x3_state",
        "description": "source-defined X3 state. Maps to SBML symbol `x3` and is emitted in native SBML units."
      },
      {
        "name": "state",
        "label": "Observable state",
        "maps_to": "signaling_sbml_wanant2000_insulinreceptormodel_a_model1201140005_model.state"
      },
      {
        "name": "summary",
        "label": "Simulation summary",
        "maps_to": "signaling_sbml_wanant2000_insulinreceptormodel_a_model1201140005_model.summary"
      },
      {
        "name": "species_labels",
        "label": "Observable labels",
        "maps_to": "signaling_sbml_wanant2000_insulinreceptormodel_a_model1201140005_model.species_labels"
      }
    ]
  },
  "tags": [
    "signaling",
    "systems",
    "systems-biology",
    "sbml",
    "faithful",
    "biomodels_ebi",
    "gpcr",
    "metabolic-signaling",
    "hormone-signaling"
  ],
  "title": "Wanant2000_InsulinReceptorModel_A Lab",
  "models": [
    {
      "path": "owned/models/signaling_sbml_wanant2000_insulinreceptormodel_a_model1201140005_model",
      "alias": "signaling_sbml_wanant2000_insulinreceptormodel_a_model1201140005_model",
      "provenance": {
        "owned_path": "owned/models/signaling_sbml_wanant2000_insulinreceptormodel_a_model1201140005_model"
      }
    },
    {
      "path": "owned/models/visualisation",
      "alias": "visualisation",
      "provenance": {
        "owned_path": "owned/models/visualisation"
      }
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.signaling_sbml_wanant2000_insulinreceptormodel_a_model1201140005_model_state"
      ],
      "from": "signaling_sbml_wanant2000_insulinreceptormodel_a_model1201140005_model.state"
    },
    {
      "to": [
        "visualisation.signaling_sbml_wanant2000_insulinreceptormodel_a_model1201140005_model_summary"
      ],
      "from": "signaling_sbml_wanant2000_insulinreceptormodel_a_model1201140005_model.summary"
    },
    {
      "to": [
        "visualisation.signaling_sbml_wanant2000_insulinreceptormodel_a_model1201140005_model_species_labels"
      ],
      "from": "signaling_sbml_wanant2000_insulinreceptormodel_a_model1201140005_model.species_labels"
    }
  ],
  "runtime": {
    "duration": 1,
    "initial_inputs": {},
    "communication_step": 0.1
  },
  "description": "Clean Biosimulant lab for metabolic and hormone-linked signaling. Values are native SBML quantities; equations, parameters, and initial values remain in the bundled source file.",
  "schema_version": "2.0"
}

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