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Potter2005 - Response Continuous Pulsatile Pth Dosing Mathematical Lab

About lab

Source-faithful physiology lab for Potter, Greller, Cho, Nuttall, Stroup, Suva, Tobin, 2005. Public controls and outputs are mapped to real source symbols for bone and endocrine physiology.

Runtime

Duration0.01
Comms Step0.01
Settle Steps1

Runs

Total0
Completed0
Failed0

Metadata

Packagepotter2005-response-continuous-pulsatile-pth-dosing-mathematical
Created2026-05-23
Updated2026-05-23
physiologycellmlphysiomefaithfulvisualisationother

Manifest

{
  "io": {
    "inputs": [
      {
        "name": "initial_active_parathyroid_hormone_parathyroid_hormone_type_1_receptor",
        "label": "Initial Active Parathyroid Hormone Parathyroid Hormone Type 1 Receptor",
        "maps_to": "physiology_cellml_potter_greller_cho_nuttall_stroup_suva_tobin_200_pottergrellerchonuttallstroupsuvatobin2005_model.initial_active_parathyroid_hormone_parathyroid_hormone_type_1_receptor",
        "description": "Initial value for Active Parathyroid Hormone Parathyroid Hormone Type 1 Receptor. Maps to source symbol `Ca`. Units: picomolar. Naming evidence: source metadata names `Ca` as `active parathyroid hormone-parathyroid hormone Type 1 receptor`.",
        "accepted_units": [
          "picomolar"
        ]
      },
      {
        "name": "initial_inactive_parathyroid_hormone_parathyroid_hormone_type_1_receptor",
        "label": "Initial Inactive Parathyroid Hormone Parathyroid Hormone Type 1 Receptor",
        "maps_to": "physiology_cellml_potter_greller_cho_nuttall_stroup_suva_tobin_200_pottergrellerchonuttallstroupsuvatobin2005_model.initial_inactive_parathyroid_hormone_parathyroid_hormone_type_1_receptor",
        "description": "Initial value for Inactive Parathyroid Hormone Parathyroid Hormone Type 1 Receptor. Maps to source symbol `Ci`. Units: picomolar. Naming evidence: source metadata names `Ci` as `inactive parathyroid hormone-parathyroid hormone Type 1 receptor`.",
        "accepted_units": [
          "picomolar"
        ]
      }
    ],
    "outputs": [
      {
        "name": "state",
        "label": "Selected Source State",
        "maps_to": "physiology_cellml_potter_greller_cho_nuttall_stroup_suva_tobin_200_pottergrellerchonuttallstroupsuvatobin2005_model.state"
      },
      {
        "name": "summary",
        "label": "Simulation Summary",
        "maps_to": "physiology_cellml_potter_greller_cho_nuttall_stroup_suva_tobin_200_pottergrellerchonuttallstroupsuvatobin2005_model.summary"
      },
      {
        "name": "trajectory",
        "label": "Source Trajectory",
        "maps_to": "physiology_cellml_potter_greller_cho_nuttall_stroup_suva_tobin_200_pottergrellerchonuttallstroupsuvatobin2005_model.trajectory"
      },
      {
        "name": "variable_labels",
        "label": "Observable Labels",
        "maps_to": "physiology_cellml_potter_greller_cho_nuttall_stroup_suva_tobin_200_pottergrellerchonuttallstroupsuvatobin2005_model.variable_labels"
      },
      {
        "name": "active_parathyroid_hormone_parathyroid_hormone_type_1_receptor",
        "label": "Active Parathyroid Hormone Parathyroid Hormone Type 1 Receptor",
        "maps_to": "physiology_cellml_potter_greller_cho_nuttall_stroup_suva_tobin_200_pottergrellerchonuttallstroupsuvatobin2005_model.active_parathyroid_hormone_parathyroid_hormone_type_1_receptor",
        "description": "Active Parathyroid Hormone Parathyroid Hormone Type 1 Receptor. Maps to source symbol `Ca`. Units: picomolar. Naming evidence: source metadata names `Ca` as `active parathyroid hormone-parathyroid hormone Type 1 receptor`."
      },
      {
        "name": "inactive_parathyroid_hormone_parathyroid_hormone_type_1_receptor",
        "label": "Inactive Parathyroid Hormone Parathyroid Hormone Type 1 Receptor",
        "maps_to": "physiology_cellml_potter_greller_cho_nuttall_stroup_suva_tobin_200_pottergrellerchonuttallstroupsuvatobin2005_model.inactive_parathyroid_hormone_parathyroid_hormone_type_1_receptor",
        "description": "Inactive Parathyroid Hormone Parathyroid Hormone Type 1 Receptor. Maps to source symbol `Ci`. Units: picomolar. Naming evidence: source metadata names `Ci` as `inactive parathyroid hormone-parathyroid hormone Type 1 receptor`."
      },
      {
        "name": "inactive_parathyroid_hormone_type_1_receptor",
        "label": "Inactive Parathyroid Hormone Type 1 Receptor",
        "maps_to": "physiology_cellml_potter_greller_cho_nuttall_stroup_suva_tobin_200_pottergrellerchonuttallstroupsuvatobin2005_model.inactive_parathyroid_hormone_type_1_receptor",
        "description": "Inactive Parathyroid Hormone Type 1 Receptor. Maps to source symbol `Ri`. Units: picomolar. Naming evidence: source metadata names `Ri` as `inactive parathyroid hormone Type 1 receptor`."
      },
      {
        "name": "active_pth1_r",
        "label": "Active Pth1 R",
        "maps_to": "physiology_cellml_potter_greller_cho_nuttall_stroup_suva_tobin_200_pottergrellerchonuttallstroupsuvatobin2005_model.active_pth1_r",
        "description": "Active Pth1 R. Maps to source symbol `Ra`. Units: picomolar. Naming evidence: source metadata names `Ra` as `active PTH1R`."
      },
      {
        "name": "parathyroid_hormone",
        "label": "Parathyroid Hormone",
        "maps_to": "physiology_cellml_potter_greller_cho_nuttall_stroup_suva_tobin_200_pottergrellerchonuttallstroupsuvatobin2005_model.parathyroid_hormone",
        "description": "Parathyroid Hormone. Maps to source symbol `P`. Units: picomolar. Naming evidence: source metadata names `P` as `parathyroid hormone`."
      },
      {
        "name": "kcl",
        "label": "Kcl",
        "maps_to": "physiology_cellml_potter_greller_cho_nuttall_stroup_suva_tobin_200_pottergrellerchonuttallstroupsuvatobin2005_model.kcl",
        "description": "Kcl. Maps to source symbol `kcl`. Units: first_order_rate_constant. Naming evidence: source symbol, component, or units provide a direct public name."
      }
    ]
  },
  "title": "Potter2005 - Response Continuous Pulsatile Pth Dosing Mathematical Lab",
  "models": [
    {
      "path": "owned/models/physiology_cellml_potter_greller_cho_nuttall_stroup_suva_tobin_200_pottergrellerchonuttallstroupsuvatobin2005_model",
      "alias": "physiology_cellml_potter_greller_cho_nuttall_stroup_suva_tobin_200_pottergrellerchonuttallstroupsuvatobin2005_model",
      "parameters": {
        "model_path": "data/potter_greller_cho_nuttall_stroup_suva_tobin_2005_a.cellml",
        "integration_step": 0.01
      },
      "provenance": {
        "owned_path": "owned/models/physiology_cellml_potter_greller_cho_nuttall_stroup_suva_tobin_200_pottergrellerchonuttallstroupsuvatobin2005_model"
      }
    },
    {
      "path": "owned/models/visualisation",
      "alias": "visualisation",
      "provenance": {
        "owned_path": "owned/models/visualisation"
      }
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.physiology_cellml_potter_greller_cho_nuttall_stroup_suva_tobin_200_pottergrellerchonuttallstroupsuvatobin2005_model_state"
      ],
      "from": "physiology_cellml_potter_greller_cho_nuttall_stroup_suva_tobin_200_pottergrellerchonuttallstroupsuvatobin2005_model.state"
    },
    {
      "to": [
        "visualisation.physiology_cellml_potter_greller_cho_nuttall_stroup_suva_tobin_200_pottergrellerchonuttallstroupsuvatobin2005_model_summary"
      ],
      "from": "physiology_cellml_potter_greller_cho_nuttall_stroup_suva_tobin_200_pottergrellerchonuttallstroupsuvatobin2005_model.summary"
    },
    {
      "to": [
        "visualisation.physiology_cellml_potter_greller_cho_nuttall_stroup_suva_tobin_200_pottergrellerchonuttallstroupsuvatobin2005_model_trajectory"
      ],
      "from": "physiology_cellml_potter_greller_cho_nuttall_stroup_suva_tobin_200_pottergrellerchonuttallstroupsuvatobin2005_model.trajectory"
    },
    {
      "to": [
        "visualisation.physiology_cellml_potter_greller_cho_nuttall_stroup_suva_tobin_200_pottergrellerchonuttallstroupsuvatobin2005_model_variable_labels"
      ],
      "from": "physiology_cellml_potter_greller_cho_nuttall_stroup_suva_tobin_200_pottergrellerchonuttallstroupsuvatobin2005_model.variable_labels"
    }
  ],
  "runtime": {
    "duration": 0.01,
    "settle_steps": 1,
    "initial_inputs": {},
    "communication_step": 0.01
  },
  "description": "Source-faithful physiology lab for Potter, Greller, Cho, Nuttall, Stroup, Suva, Tobin, 2005. Public controls and outputs are mapped to real source symbols for bone and endocrine physiology.",
  "schema_version": "2.0"
}

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