About lab
Koo2013 Integrated Shear-Stress Induced NO Production Lab
This lab wraps the integrated Koo et al. (2013) endothelial mechanotransduction model from BioModels source BIOMD0000000468. The canvas model is named koo2013_integrated_shear_stress_no_production, matching the screenshots below, and connects a shear-stress stimulus surrogate through calcium handling, mechanosensor signalling, eNOS activation, and nitric oxide production. The models/core package handles SBML execution and numeric outputs, while models/visualisation owns internal grouped charts and narrative logic.
Use this lab when the question is the end-to-end NO-production response rather than the isolated calcium-influx or NO-production submodules.
Results Preview
The default published run spans 600 s and renders 10 visualization panels. The first view shows the canvas wiring beside the mechanical-input and calcium-subsystem plots. stimulus_intensity acts as the practical shear-stress input by driving IP3 production, while the calcium panel tracks extracellular, stored, cytosolic, buffered, IP3, and calmodulin-related pools.
The mid-run results expose the upstream signalling cascade. The mechanosensor panel follows FAK, Src, Shc, Ras, and adapter complexes, while the adjacent PI3K/AKT panel shows the downstream kinase axis that links mechanical stimulation to eNOS regulation.
The later panels focus on vasoactive output and negative regulation. Nitric oxide accumulates across the 600 s run as the active eNOS complex converts L-arginine, while PP2A and PTEN provide the regulatory phosphatase context.
The summary view reports 65 species observables, identifies stored calcium in the ER lumen as the largest excursion, and notes that 26 of 65 observables settled within 1% over the final 10% of the run.
Model Files
| Path | Purpose |
|---|---|
lab.yaml | Lab title, IO wiring, runtime defaults, and canvas metadata. |
models/core/model.yaml | Core SBML execution package metadata, parameters, inputs, outputs, and units. |
models/core/src/koo2013_integrated_shear_stress_no_production.py | Tellurium-backed SBML execution wrapper. |
models/core/data/BIOMD0000000468.xml | Curated SBML model file from BioModels. |
models/visualisation/ | Internal presentation model for charts and narrative logic. |
models/*/tests/ | Smoke coverage for core execution and visualisation behavior. |
Inputs and Outputs
Inputs:
stimulus_intensity(1/s): IP3-production rate constantk1; the model's practical shear-stress stimulus surrogate.integration_step(s): Tellurium output sampling interval.
Outputs:
active_eNOS: active eNOS-CaM-Ca4 complex amount, averaged over the wrapper's headline window.cytosolic_calcium: cytosolic calcium amount, averaged over the wrapper's headline window.nitric_oxide: nitric oxide amount, averaged over the wrapper's headline window.state: latest values for the tracked named species.summary: final, peak, minimum, and excursion diagnostics for the run.
Notes
The upstream SBML Shear Stress species is decorative in this wrapper; use stimulus_intensity for perturbation experiments. The state output carries 65 named species after filtering mass-balance placeholders from the 79-species SBML model.
Koo et al. (2013) integrated endothelial mechanotransduction model combining shear-stress sensing, calcium influx, eNOS activation, and NO production into a single ODE system.
Runtime
Duration600
Comms Step10
Runs
Total3
Completed3
Failed0
Metadata
Packagekoo2013-integrated-shear-stress-induced-no-production-lab
Created2026-05-04
Updated2026-05-14
biomechanicsendothelialshear-stressnitric-oxidemechanotransductionsbmlbiomodels_ebifaithfulvisualisationkoo2013
Manifest
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}Sign in to start your own run. Public-lab history stays visible here.
Logs
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JSON
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"title": "Koo2013 Integrated Shear-Stress Induced NO Production - PI3K / AKT signalling",
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},
"description": "How does PI3K signalling activate AKT?",
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],
"title": "Koo2013 Integrated Shear-Stress Induced NO Production - Regulatory phosphatases",
"x_unit": "s"
},
"description": "How do the deactivating phosphatases respond?",
"render": "timeseries"
},
{
"data": {
"categories": [
"Stored calcium",
"Nitric oxide",
"Buffered calcium",
"Calmodulin",
"Calmodulin Ca2 complex",
"Cytosolic calcium",
"Simulation time",
"Pre-step time"
],
"title": "Koo2013 Integrated Shear-Stress Induced NO Production - largest excursions during the run",
"values": [
2396423.1278739567,
110226.45341271991,
28472.325022708956,
2210.325593338207,
1999.1242399147163,
993.1342749072631,
590,
590
]
},
"description": "Which observables shifted the most during the run?",
"render": "bar"
},
{
"data": {
"columns": [
"Question",
"Answer"
],
"rows": [
[
"What did this run track?",
"65 observables in Koo2013 Integrated Shear-Stress Induced NO Production"
],
[
"How long did it run?",
"590 s"
],
[
"Which observable changed the most?",
"Stored calcium"
],
[
"Largest peak?",
"Stored calcium"
]
],
"title": "What Happened"
},
"description": "What did this simulation actually show, in plain language?",
"render": "table"
}
]
}
]
}