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Alexander2010 Tcell Regulation Sys2 Lab

About lab

This is system 2, the model with Michelis Menten type antigen uptake by pAPCs, described in the article: Self-tolerance and Autoimmunity in a Regulatory T Cell Model. It can be used to explore immune response dynamics and compare pathway-level behavior across conditions.

Runtime

Duration10
Comms Step1

Runs

Total0
Completed0
Failed0

Metadata

Packagealexander2010-tcell-regulation-sys2-lab
Created2026-05-15
Updated2026-05-15
immunologysbmlbiomodels_ebifaithfulcuratedvisualisation

Manifest

{
  "io": {
    "inputs": [
      {
        "name": "initial_unresolved_immune_observable_1",
        "label": "Initial Unresolved Immune Observable 1",
        "units": "native source value",
        "default": 1,
        "maps_to": "immunology_sbml_alexander2010_tcell_regulation_sys2_biomd0000000290_model.initial_unresolved_immune_observable_1",
        "description": "Initial Unresolved Immune Observable 1. Sets the initial value of bundled SBML species `A`."
      },
      {
        "name": "initial_unresolved_immune_observable_2",
        "label": "Initial Unresolved Immune Observable 2",
        "units": "native source value",
        "default": 0,
        "maps_to": "immunology_sbml_alexander2010_tcell_regulation_sys2_biomd0000000290_model.initial_unresolved_immune_observable_2",
        "description": "Initial Unresolved Immune Observable 2. Sets the initial value of bundled SBML species `R`."
      },
      {
        "name": "initial_unresolved_immune_observable_3",
        "label": "Initial Unresolved Immune Observable 3",
        "units": "native source value",
        "default": 0,
        "maps_to": "immunology_sbml_alexander2010_tcell_regulation_sys2_biomd0000000290_model.initial_unresolved_immune_observable_3",
        "description": "Initial Unresolved Immune Observable 3. Sets the initial value of bundled SBML species `E`."
      },
      {
        "name": "initial_unresolved_immune_observable_4",
        "label": "Initial Unresolved Immune Observable 4",
        "units": "native source value",
        "default": 100000000,
        "maps_to": "immunology_sbml_alexander2010_tcell_regulation_sys2_biomd0000000290_model.initial_unresolved_immune_observable_4",
        "description": "Initial Unresolved Immune Observable 4. Sets the initial value of bundled SBML species `G`."
      },
      {
        "name": "r2_self_antigen_release_triggered_by_e_rate",
        "label": "R2 Self Antigen Release Triggered By E Rate",
        "units": "per_day",
        "default": 2000,
        "maps_to": "immunology_sbml_alexander2010_tcell_regulation_sys2_biomd0000000290_model.r2_self_antigen_release_triggered_by_e_rate",
        "description": "R2 Self Antigen Release Triggered By E Rate. Sets bundled SBML parameter `gamma`."
      }
    ],
    "outputs": [
      {
        "name": "unresolved_immune_observable_1",
        "maps_to": "immunology_sbml_alexander2010_tcell_regulation_sys2_biomd0000000290_model.unresolved_immune_observable_1"
      },
      {
        "name": "unresolved_immune_observable_2",
        "maps_to": "immunology_sbml_alexander2010_tcell_regulation_sys2_biomd0000000290_model.unresolved_immune_observable_2"
      },
      {
        "name": "unresolved_immune_observable_3",
        "maps_to": "immunology_sbml_alexander2010_tcell_regulation_sys2_biomd0000000290_model.unresolved_immune_observable_3"
      },
      {
        "name": "unresolved_immune_observable_4",
        "maps_to": "immunology_sbml_alexander2010_tcell_regulation_sys2_biomd0000000290_model.unresolved_immune_observable_4"
      },
      {
        "name": "unresolved_immune_observable_5",
        "maps_to": "immunology_sbml_alexander2010_tcell_regulation_sys2_biomd0000000290_model.unresolved_immune_observable_5"
      },
      {
        "name": "state",
        "maps_to": "immunology_sbml_alexander2010_tcell_regulation_sys2_biomd0000000290_model.state"
      },
      {
        "name": "summary",
        "maps_to": "immunology_sbml_alexander2010_tcell_regulation_sys2_biomd0000000290_model.summary"
      },
      {
        "name": "species_labels",
        "maps_to": "immunology_sbml_alexander2010_tcell_regulation_sys2_biomd0000000290_model.species_labels"
      }
    ]
  },
  "title": "Alexander2010 Tcell Regulation Sys2 Lab",
  "models": [
    {
      "path": "owned/models/immunology_sbml_alexander2010_tcell_regulation_sys2_biomd0000000290_model",
      "alias": "immunology_sbml_alexander2010_tcell_regulation_sys2_biomd0000000290_model",
      "provenance": {
        "owned_path": "owned/models/immunology_sbml_alexander2010_tcell_regulation_sys2_biomd0000000290_model"
      }
    },
    {
      "path": "owned/models/visualisation",
      "alias": "visualisation",
      "provenance": {
        "owned_path": "owned/models/visualisation"
      }
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.immunology_sbml_alexander2010_tcell_regulation_sys2_biomd0000000290_model_state"
      ],
      "from": "immunology_sbml_alexander2010_tcell_regulation_sys2_biomd0000000290_model.state"
    },
    {
      "to": [
        "visualisation.immunology_sbml_alexander2010_tcell_regulation_sys2_biomd0000000290_model_summary"
      ],
      "from": "immunology_sbml_alexander2010_tcell_regulation_sys2_biomd0000000290_model.summary"
    },
    {
      "to": [
        "visualisation.immunology_sbml_alexander2010_tcell_regulation_sys2_biomd0000000290_model_species_labels"
      ],
      "from": "immunology_sbml_alexander2010_tcell_regulation_sys2_biomd0000000290_model.species_labels"
    }
  ],
  "runtime": {
    "duration": 10,
    "initial_inputs": {},
    "communication_step": 1
  },
  "description": "This is system 2, the model with Michelis Menten type antigen uptake by pAPCs, described in the article: Self-tolerance and Autoimmunity in a Regulatory T Cell Model. It can be used to explore immune response dynamics and compare pathway-level behavior across conditions.",
  "schema_version": "2.0"
}

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