Gevertz2018 - Cancer Treatment with Oncolytic Viruses and Dendritic Cell injections original model Lab

{
  "io": {
    "inputs": [
      {
        "name": "c_kill_source_parameter",
        "label": "C kill source parameter",
        "units": "native SBML value",
        "default": 0.595397,
        "maps_to": "oncology_sbml_gevertz2018_cancer_treatment_with_oncolytic_viru_biomd0000000816_model.c_kill_source_parameter",
        "description": "C kill source parameter. Maps to bundled SBML parameter `c_kill`."
      },
      {
        "name": "ov_dose_source_parameter",
        "label": "OV dose source parameter",
        "units": "native SBML value",
        "default": 2.5,
        "maps_to": "oncology_sbml_gevertz2018_cancer_treatment_with_oncolytic_viru_biomd0000000816_model.ov_dose_source_parameter",
        "description": "OV dose source parameter. Maps to bundled SBML parameter `OV_dose`."
      },
      {
        "name": "initial_uninfected_tumor_cell_u",
        "label": "Uninfected Tumor Cell U",
        "units": "native SBML value",
        "default": 58.020755,
        "maps_to": "oncology_sbml_gevertz2018_cancer_treatment_with_oncolytic_viru_biomd0000000816_model.initial_uninfected_tumor_cell_u",
        "description": "Initial Uninfected Tumor Cell U. Sets the initial value of bundled SBML symbol `Uninfected_Tumor_Cell_U`."
      },
      {
        "name": "initial_tumor_targeting_t_cells_t",
        "label": "Tumor targeting T cells T",
        "units": "native SBML value",
        "default": 0,
        "maps_to": "oncology_sbml_gevertz2018_cancer_treatment_with_oncolytic_viru_biomd0000000816_model.initial_tumor_targeting_t_cells_t",
        "description": "Initial Tumor targeting T cells T. Sets the initial value of bundled SBML symbol `Tumor_targeting_T_cells_T`."
      },
      {
        "name": "initial_infected_cancer_cell_i",
        "label": "Infected Cancer Cell I",
        "units": "native SBML value",
        "default": 0,
        "maps_to": "oncology_sbml_gevertz2018_cancer_treatment_with_oncolytic_viru_biomd0000000816_model.initial_infected_cancer_cell_i",
        "description": "Initial Infected Cancer Cell I. Sets the initial value of bundled SBML symbol `Infected_Cancer_Cell_I`."
      },
      {
        "name": "initial_naive_t_cells_a",
        "label": "Naive T cells A",
        "units": "native SBML value",
        "default": 0,
        "maps_to": "oncology_sbml_gevertz2018_cancer_treatment_with_oncolytic_viru_biomd0000000816_model.initial_naive_t_cells_a",
        "description": "Initial Naive T cells A. Sets the initial value of bundled SBML symbol `Naive_T_cells_A`."
      }
    ],
    "outputs": [
      {
        "name": "uninfected_tumor_cell_u",
        "maps_to": "oncology_sbml_gevertz2018_cancer_treatment_with_oncolytic_viru_biomd0000000816_model.uninfected_tumor_cell_u",
        "description": "Uninfected Tumor Cell U observable. Maps to SBML symbol `Uninfected_Tumor_Cell_U`."
      },
      {
        "name": "tumor_targeting_t_cells_t",
        "maps_to": "oncology_sbml_gevertz2018_cancer_treatment_with_oncolytic_viru_biomd0000000816_model.tumor_targeting_t_cells_t",
        "description": "Tumor targeting T cells T observable. Maps to SBML symbol `Tumor_targeting_T_cells_T`."
      },
      {
        "name": "infected_cancer_cell_i",
        "maps_to": "oncology_sbml_gevertz2018_cancer_treatment_with_oncolytic_viru_biomd0000000816_model.infected_cancer_cell_i",
        "description": "Infected Cancer Cell I observable. Maps to SBML symbol `Infected_Cancer_Cell_I`."
      },
      {
        "name": "naive_t_cells_a",
        "maps_to": "oncology_sbml_gevertz2018_cancer_treatment_with_oncolytic_viru_biomd0000000816_model.naive_t_cells_a",
        "description": "Naive T cells A observable. Maps to SBML symbol `Naive_T_cells_A`."
      },
      {
        "name": "dendritic_cells_d",
        "maps_to": "oncology_sbml_gevertz2018_cancer_treatment_with_oncolytic_viru_biomd0000000816_model.dendritic_cells_d",
        "description": "Dendritic Cells D observable. Maps to SBML symbol `Dendritic_Cells_D`."
      },
      {
        "name": "oncolytic_adenovirus_v",
        "maps_to": "oncology_sbml_gevertz2018_cancer_treatment_with_oncolytic_viru_biomd0000000816_model.oncolytic_adenovirus_v",
        "description": "Oncolytic Adenovirus V observable. Maps to SBML symbol `Oncolytic_Adenovirus_V`."
      },
      {
        "name": "state",
        "maps_to": "oncology_sbml_gevertz2018_cancer_treatment_with_oncolytic_viru_biomd0000000816_model.state",
        "description": "Full raw SBML observable record for reproducibility and downstream visualisation."
      },
      {
        "name": "summary",
        "maps_to": "oncology_sbml_gevertz2018_cancer_treatment_with_oncolytic_viru_biomd0000000816_model.summary",
        "description": "Change and peak summary across the simulated SBML observables."
      },
      {
        "name": "species_labels",
        "maps_to": "oncology_sbml_gevertz2018_cancer_treatment_with_oncolytic_viru_biomd0000000816_model.species_labels",
        "description": "Mapping from selected raw SBML observable symbols to display labels."
      }
    ]
  },
  "tags": [
    "biomodels_ebi",
    "curated",
    "drug-response",
    "faithful",
    "immunotherapy",
    "oncology",
    "pharmacology",
    "physiology",
    "sbml",
    "systemsbiology",
    "tumor-growth",
    "virotherapy"
  ],
  "title": "Gevertz2018 - Cancer Treatment with Oncolytic Viruses and Dendritic Cell injections original model Lab",
  "models": [
    {
      "path": "owned/models/oncology_sbml_gevertz2018_cancer_treatment_with_oncolytic_viru_biomd0000000816_model",
      "alias": "oncology_sbml_gevertz2018_cancer_treatment_with_oncolytic_viru_biomd0000000816_model",
      "provenance": {
        "owned_path": "owned/models/oncology_sbml_gevertz2018_cancer_treatment_with_oncolytic_viru_biomd0000000816_model"
      }
    },
    {
      "path": "owned/models/visualisation",
      "alias": "visualisation",
      "provenance": {
        "owned_path": "owned/models/visualisation"
      }
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.oncology_sbml_gevertz2018_cancer_treatment_with_oncolytic_viru_biomd0000000816_model_state"
      ],
      "from": "oncology_sbml_gevertz2018_cancer_treatment_with_oncolytic_viru_biomd0000000816_model.state"
    },
    {
      "to": [
        "visualisation.oncology_sbml_gevertz2018_cancer_treatment_with_oncolytic_viru_biomd0000000816_model_summary"
      ],
      "from": "oncology_sbml_gevertz2018_cancer_treatment_with_oncolytic_viru_biomd0000000816_model.summary"
    },
    {
      "to": [
        "visualisation.oncology_sbml_gevertz2018_cancer_treatment_with_oncolytic_viru_biomd0000000816_model_species_labels"
      ],
      "from": "oncology_sbml_gevertz2018_cancer_treatment_with_oncolytic_viru_biomd0000000816_model.species_labels"
    }
  ],
  "runtime": {
    "duration": 10,
    "initial_inputs": {},
    "communication_step": 1
  },
  "description": "The model is based on 'Developing a Minimally Structured Mathematical Model of Cancer Treatment with Oncolytic Viruses and Dendritic Cell Injections', PMID:30510594. It can be used to explore tumor-related dynamics and compare treatment-response behavior across conditions.",
  "schema_version": "2.0"
}