Chen2007 Neuronal Endothelial Nos Lab

{
  "io": {
    "inputs": [
      {
        "name": "integration_step",
        "maps_to": "chen2007_neuronal_endothelial_nos_core.integration_step"
      },
      {
        "name": "parameter_overrides",
        "maps_to": "chen2007_neuronal_endothelial_nos_core.parameter_overrides"
      },
      {
        "name": "initial_conditions",
        "maps_to": "chen2007_neuronal_endothelial_nos_core.initial_conditions"
      }
    ],
    "outputs": [
      {
        "name": "scenario_metadata",
        "maps_to": "chen2007_neuronal_endothelial_nos_scenario.scenario_metadata"
      },
      {
        "name": "state",
        "maps_to": "chen2007_neuronal_endothelial_nos_core.state"
      },
      {
        "name": "run_summary",
        "maps_to": "chen2007_neuronal_endothelial_nos_viz.run_summary"
      }
    ]
  },
  "title": "Chen2007 Neuronal Endothelial Nos Lab",
  "models": [
    {
      "path": "owned/models/chen2007_neuronal_endothelial_nos_scenario",
      "alias": "chen2007_neuronal_endothelial_nos_scenario",
      "parameters": {
        "schedule": {
          "oxygen": {
            "unit": "dimensionless",
            "label": "oxygen",
            "active": false,
            "baseline": 0,
            "recovery": 0,
            "challenge": 0,
            "description": "Scenario-controlled oxygen value."
          },
          "l_arginine": {
            "unit": "dimensionless",
            "label": "l arginine",
            "active": true,
            "baseline": 0,
            "recovery": 0,
            "challenge": 1,
            "description": "Scenario-controlled l arginine value."
          },
          "nitric_oxide_synthase_pool": {
            "unit": "dimensionless",
            "label": "nitric oxide synthase pool",
            "active": false,
            "baseline": 0.3,
            "recovery": 0.3,
            "challenge": 0.3,
            "description": "Scenario-controlled nitric oxide synthase pool value."
          }
        },
        "scenario_name": "L arginine challenge",
        "baseline_until": 0.25,
        "challenge_until": 0.75,
        "scenario_description": "Baseline is followed by a l arginine challenge and recovery period."
      },
      "provenance": {
        "owned_path": "owned/models/chen2007_neuronal_endothelial_nos_scenario"
      }
    },
    {
      "path": "owned/models/chen2007_neuronal_endothelial_nos_core",
      "alias": "chen2007_neuronal_endothelial_nos_core",
      "parameters": {
        "model_path": "data/MODEL0491251823.xml",
        "integration_step": 0.001
      },
      "provenance": {
        "owned_path": "owned/models/chen2007_neuronal_endothelial_nos_core"
      }
    },
    {
      "path": "owned/models/chen2007_neuronal_endothelial_nos_viz",
      "alias": "chen2007_neuronal_endothelial_nos_viz",
      "parameters": {
        "lab_title": "Chen2007 Neuronal Endothelial Nos",
        "lab_question": "How do nitric oxide synthase pathways shape nitric oxide availability?",
        "integration_step": 0.001
      },
      "provenance": {
        "owned_path": "owned/models/chen2007_neuronal_endothelial_nos_viz"
      }
    }
  ],
  "wiring": [
    {
      "to": [
        "chen2007_neuronal_endothelial_nos_core.l_arginine"
      ],
      "from": "chen2007_neuronal_endothelial_nos_scenario.l_arginine"
    },
    {
      "to": [
        "chen2007_neuronal_endothelial_nos_core.oxygen"
      ],
      "from": "chen2007_neuronal_endothelial_nos_scenario.oxygen"
    },
    {
      "to": [
        "chen2007_neuronal_endothelial_nos_core.nitric_oxide_synthase_pool"
      ],
      "from": "chen2007_neuronal_endothelial_nos_scenario.nitric_oxide_synthase_pool"
    },
    {
      "to": [
        "chen2007_neuronal_endothelial_nos_viz.scenario_metadata"
      ],
      "from": "chen2007_neuronal_endothelial_nos_scenario.scenario_metadata"
    },
    {
      "to": [
        "chen2007_neuronal_endothelial_nos_viz.state"
      ],
      "from": "chen2007_neuronal_endothelial_nos_core.state"
    },
    {
      "to": [
        "chen2007_neuronal_endothelial_nos_viz.species_labels"
      ],
      "from": "chen2007_neuronal_endothelial_nos_core.species_labels"
    }
  ],
  "runtime": {
    "duration": 1,
    "initial_inputs": {
      "chen2007_neuronal_endothelial_nos_core": {
        "integration_step": 0.001,
        "initial_conditions": {
          "payload": {}
        },
        "parameter_overrides": {
          "payload": {}
        }
      }
    },
    "communication_step": 0.001
  },
  "description": "Two-model lab for Chen2007 Neuronal Endothelial Nos: a core SBML simulator wired into a dedicated visualization sub-model that turns the raw state into friendly timeseries and a plain-language summary. This a model from the article: Vascular and perivascular nitric oxide release and transport: biochemical pathways of neuronal nitric oxide synthase (NOS1) and endothelial nitric oxide synthase (NOS3). It can be used to explore cardiac dynamics and compare response patterns across conditions.",
  "schema_version": "2.0"
}