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Malinzi2018 - tumour-immune interaction model Lab

About lab

The paper describes a spatio-temporal mathematical model, in the form of a moving boundary problem, to explain cancer dormancy is developed. It can be used to explore immune response dynamics and compare pathway-level behavior across conditions.

Runtime

Duration10
Comms Step1

Runs

Total0
Completed0
Failed0

Metadata

Packagemalinzi2018-tumour-immune-interaction-model-lab
Created2026-05-15
Updated2026-05-15
immunologysbmlbiomodels_ebifaithfulcuratedvisualisation

Manifest

{
  "io": {
    "inputs": [
      {
        "name": "initial_immune_cell_x",
        "label": "Initial Immune Cell X",
        "units": "native source value",
        "default": 0.3,
        "maps_to": "immunology_sbml_malinzi2018_tumour_immune_interaction_model_biomd0000000809_model.initial_immune_cell_x",
        "description": "Initial Immune Cell X. Sets the initial value of bundled SBML species `x`."
      },
      {
        "name": "initial_tumour_cell_y",
        "label": "Initial Tumour Cell Y",
        "units": "native source value",
        "default": 0.8,
        "maps_to": "immunology_sbml_malinzi2018_tumour_immune_interaction_model_biomd0000000809_model.initial_tumour_cell_y",
        "description": "Initial Tumour Cell Y. Sets the initial value of bundled SBML species `y`."
      },
      {
        "name": "initial_dead_tumour_cell_ystar",
        "label": "Initial Dead Tumour Cell Ystar",
        "units": "native source value",
        "default": 0.1,
        "maps_to": "immunology_sbml_malinzi2018_tumour_immune_interaction_model_biomd0000000809_model.initial_dead_tumour_cell_ystar",
        "description": "Initial Dead Tumour Cell Ystar. Sets the initial value of bundled SBML species `ystar`."
      },
      {
        "name": "initial_chemokine_concentration_u",
        "label": "Initial Chemokine Concentration U",
        "units": "native source value",
        "default": "1e-6",
        "maps_to": "immunology_sbml_malinzi2018_tumour_immune_interaction_model_biomd0000000809_model.initial_chemokine_concentration_u",
        "description": "Initial Chemokine Concentration U. Sets the initial value of bundled SBML species `u`."
      },
      {
        "name": "immune_cell_x_proliferation_rate",
        "label": "Immune Cell X Proliferation Rate",
        "units": "native source value",
        "default": 3.0218,
        "maps_to": "immunology_sbml_malinzi2018_tumour_immune_interaction_model_biomd0000000809_model.immune_cell_x_proliferation_rate",
        "description": "Immune Cell X Proliferation Rate. Sets bundled SBML parameter `delta`."
      },
      {
        "name": "immune_cell_x_proliferation_rate_2",
        "label": "Immune Cell X Proliferation Rate 2",
        "units": "native source value",
        "default": 2.02,
        "maps_to": "immunology_sbml_malinzi2018_tumour_immune_interaction_model_biomd0000000809_model.immune_cell_x_proliferation_rate_2",
        "description": "Immune Cell X Proliferation Rate 2. Sets bundled SBML parameter `gamma`."
      }
    ],
    "outputs": [
      {
        "name": "immune_cell_x",
        "maps_to": "immunology_sbml_malinzi2018_tumour_immune_interaction_model_biomd0000000809_model.immune_cell_x"
      },
      {
        "name": "tumour_cell_y",
        "maps_to": "immunology_sbml_malinzi2018_tumour_immune_interaction_model_biomd0000000809_model.tumour_cell_y"
      },
      {
        "name": "dead_tumour_cell_ystar",
        "maps_to": "immunology_sbml_malinzi2018_tumour_immune_interaction_model_biomd0000000809_model.dead_tumour_cell_ystar"
      },
      {
        "name": "chemokine_concentration_u",
        "maps_to": "immunology_sbml_malinzi2018_tumour_immune_interaction_model_biomd0000000809_model.chemokine_concentration_u"
      },
      {
        "name": "state",
        "maps_to": "immunology_sbml_malinzi2018_tumour_immune_interaction_model_biomd0000000809_model.state"
      },
      {
        "name": "summary",
        "maps_to": "immunology_sbml_malinzi2018_tumour_immune_interaction_model_biomd0000000809_model.summary"
      },
      {
        "name": "species_labels",
        "maps_to": "immunology_sbml_malinzi2018_tumour_immune_interaction_model_biomd0000000809_model.species_labels"
      }
    ]
  },
  "title": "Malinzi2018 - tumour-immune interaction model Lab",
  "models": [
    {
      "path": "owned/models/immunology_sbml_malinzi2018_tumour_immune_interaction_model_biomd0000000809_model",
      "alias": "immunology_sbml_malinzi2018_tumour_immune_interaction_model_biomd0000000809_model",
      "provenance": {
        "owned_path": "owned/models/immunology_sbml_malinzi2018_tumour_immune_interaction_model_biomd0000000809_model"
      }
    },
    {
      "path": "owned/models/visualisation",
      "alias": "visualisation",
      "provenance": {
        "owned_path": "owned/models/visualisation"
      }
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.immunology_sbml_malinzi2018_tumour_immune_interaction_model_biomd0000000809_model_state"
      ],
      "from": "immunology_sbml_malinzi2018_tumour_immune_interaction_model_biomd0000000809_model.state"
    },
    {
      "to": [
        "visualisation.immunology_sbml_malinzi2018_tumour_immune_interaction_model_biomd0000000809_model_summary"
      ],
      "from": "immunology_sbml_malinzi2018_tumour_immune_interaction_model_biomd0000000809_model.summary"
    },
    {
      "to": [
        "visualisation.immunology_sbml_malinzi2018_tumour_immune_interaction_model_biomd0000000809_model_species_labels"
      ],
      "from": "immunology_sbml_malinzi2018_tumour_immune_interaction_model_biomd0000000809_model.species_labels"
    }
  ],
  "runtime": {
    "duration": 10,
    "initial_inputs": {},
    "communication_step": 1
  },
  "description": "The paper describes a spatio-temporal mathematical model, in the form of a moving boundary problem, to explain cancer dormancy is developed. It can be used to explore immune response dynamics and compare pathway-level behavior across conditions.",
  "schema_version": "2.0"
}

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