Grignard2022 - Detyrosination/Tyrosination Model in neurons and proliferative cells Lab

{
  "io": {
    "inputs": [
      {
        "name": "initial_detyrosinated_tubulin",
        "label": "Initial Detyrosinated Tubulin",
        "maps_to": "pharmacology_sbml_grignard2022_detyrosination_tyrosination_model_i_model2209260001_model.initial_detyrosinated_tubulin"
      },
      {
        "name": "initial_tyrosinated_tubulin",
        "label": "Initial Tyrosinated Tubulin",
        "maps_to": "pharmacology_sbml_grignard2022_detyrosination_tyrosination_model_i_model2209260001_model.initial_tyrosinated_tubulin"
      },
      {
        "name": "initial_tcp_enzyme_pool",
        "label": "Initial Tcp Enzyme Pool",
        "maps_to": "pharmacology_sbml_grignard2022_detyrosination_tyrosination_model_i_model2209260001_model.initial_tcp_enzyme_pool"
      },
      {
        "name": "initial_ttl_enzyme_pool",
        "label": "Initial Ttl Enzyme Pool",
        "maps_to": "pharmacology_sbml_grignard2022_detyrosination_tyrosination_model_i_model2209260001_model.initial_ttl_enzyme_pool"
      },
      {
        "name": "detyrosination_affinity_km",
        "label": "Detyrosination Affinity KM",
        "maps_to": "pharmacology_sbml_grignard2022_detyrosination_tyrosination_model_i_model2209260001_model.detyrosination_affinity_km"
      }
    ],
    "outputs": [
      {
        "name": "state",
        "label": "Tracked source state",
        "maps_to": "pharmacology_sbml_grignard2022_detyrosination_tyrosination_model_i_model2209260001_model.state"
      },
      {
        "name": "summary",
        "label": "Simulation summary",
        "maps_to": "pharmacology_sbml_grignard2022_detyrosination_tyrosination_model_i_model2209260001_model.summary"
      },
      {
        "name": "species_labels",
        "label": "Observable labels",
        "maps_to": "pharmacology_sbml_grignard2022_detyrosination_tyrosination_model_i_model2209260001_model.species_labels"
      },
      {
        "name": "detyrosinated_tubulin",
        "label": "Detyrosinated Tubulin",
        "maps_to": "pharmacology_sbml_grignard2022_detyrosination_tyrosination_model_i_model2209260001_model.detyrosinated_tubulin"
      },
      {
        "name": "detyrosinated_microtubules",
        "label": "Detyrosinated Microtubules",
        "maps_to": "pharmacology_sbml_grignard2022_detyrosination_tyrosination_model_i_model2209260001_model.detyrosinated_microtubules"
      },
      {
        "name": "tyrosinated_tubulin",
        "label": "Tyrosinated Tubulin",
        "maps_to": "pharmacology_sbml_grignard2022_detyrosination_tyrosination_model_i_model2209260001_model.tyrosinated_tubulin"
      },
      {
        "name": "tyrosinated_microtubules",
        "label": "Tyrosinated Microtubules",
        "maps_to": "pharmacology_sbml_grignard2022_detyrosination_tyrosination_model_i_model2209260001_model.tyrosinated_microtubules"
      },
      {
        "name": "tcp_enzyme_pool",
        "label": "Tcp Enzyme Pool",
        "maps_to": "pharmacology_sbml_grignard2022_detyrosination_tyrosination_model_i_model2209260001_model.tcp_enzyme_pool"
      },
      {
        "name": "ttl_enzyme_pool",
        "label": "Ttl Enzyme Pool",
        "maps_to": "pharmacology_sbml_grignard2022_detyrosination_tyrosination_model_i_model2209260001_model.ttl_enzyme_pool"
      }
    ]
  },
  "tags": [
    "pharmacology",
    "cell-biology",
    "neuroscience",
    "systems-biology",
    "sbml",
    "tellurium",
    "faithful",
    "biomodels_ebi"
  ],
  "title": "Grignard2022 - Detyrosination/Tyrosination Model in neurons and proliferative cells Lab",
  "models": [
    {
      "path": "owned/models/pharmacology_sbml_grignard2022_detyrosination_tyrosination_model_i_model2209260001_model",
      "alias": "pharmacology_sbml_grignard2022_detyrosination_tyrosination_model_i_model2209260001_model",
      "parameters": {
        "model_path": "data/MODEL2209260001.xml",
        "integration_step": 0.05
      },
      "provenance": {
        "owned_path": "owned/models/pharmacology_sbml_grignard2022_detyrosination_tyrosination_model_i_model2209260001_model"
      }
    },
    {
      "path": "owned/models/visualisation",
      "alias": "visualisation",
      "provenance": {
        "owned_path": "owned/models/visualisation"
      }
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.pharmacology_sbml_grignard2022_detyrosination_tyrosination_model_i_model2209260001_model_state"
      ],
      "from": "pharmacology_sbml_grignard2022_detyrosination_tyrosination_model_i_model2209260001_model.state"
    },
    {
      "to": [
        "visualisation.pharmacology_sbml_grignard2022_detyrosination_tyrosination_model_i_model2209260001_model_summary"
      ],
      "from": "pharmacology_sbml_grignard2022_detyrosination_tyrosination_model_i_model2209260001_model.summary"
    },
    {
      "to": [
        "visualisation.pharmacology_sbml_grignard2022_detyrosination_tyrosination_model_i_model2209260001_model_species_labels"
      ],
      "from": "pharmacology_sbml_grignard2022_detyrosination_tyrosination_model_i_model2209260001_model.species_labels"
    }
  ],
  "runtime": {
    "duration": 10,
    "initial_inputs": {},
    "communication_step": 0.5
  },
  "description": "SBML files for the mathematical model from the publication 'Mathematical modeling of the microtubule detyrosination/tyrosination cycle for cell-based drug screening design'. It can be used to explore dose-response dynamics and compare treatment scenarios across conditions.",
  "schema_version": "2.0"
}