Hayashi2013 - Extended TNF-induced Signaling with Gene Expression Dynamics (Model B) Lab

{
  "io": {
    "inputs": [
      {
        "name": "initial_tnfr1",
        "label": "TNFR1",
        "units": "native SBML value",
        "default": 1,
        "maps_to": "oncology_sbml_hayashi2013_extended_tnf_induced_signaling_with_model2502170002_model.initial_tnfr1",
        "description": "Initial TNFR1. Sets the initial value of bundled SBML symbol `species_3`."
      },
      {
        "name": "initial_ik_ba_nfkb",
        "label": "IkBa NFkb",
        "units": "native SBML value",
        "default": 5,
        "maps_to": "oncology_sbml_hayashi2013_extended_tnf_induced_signaling_with_model2502170002_model.initial_ik_ba_nfkb",
        "description": "Initial IkBa NFkb. Sets the initial value of bundled SBML symbol `species_1`."
      },
      {
        "name": "initial_mapk",
        "label": "MAPK",
        "units": "native SBML value",
        "default": 46,
        "maps_to": "oncology_sbml_hayashi2013_extended_tnf_induced_signaling_with_model2502170002_model.initial_mapk",
        "description": "Initial MAPK. Sets the initial value of bundled SBML symbol `species_13`."
      },
      {
        "name": "initial_nfk_bc",
        "label": "NFkBc",
        "units": "native SBML value",
        "default": 0,
        "maps_to": "oncology_sbml_hayashi2013_extended_tnf_induced_signaling_with_model2502170002_model.initial_nfk_bc",
        "description": "Initial NFkBc. Sets the initial value of bundled SBML symbol `species_2`."
      },
      {
        "name": "initial_traf6",
        "label": "TRAF6",
        "units": "native SBML value",
        "default": 0,
        "maps_to": "oncology_sbml_hayashi2013_extended_tnf_induced_signaling_with_model2502170002_model.initial_traf6",
        "description": "Initial TRAF6. Sets the initial value of bundled SBML symbol `species_6`."
      },
      {
        "name": "initial_traf5",
        "label": "TRAF5",
        "units": "native SBML value",
        "default": 0,
        "maps_to": "oncology_sbml_hayashi2013_extended_tnf_induced_signaling_with_model2502170002_model.initial_traf5",
        "description": "Initial TRAF5. Sets the initial value of bundled SBML symbol `species_7`."
      }
    ],
    "outputs": [
      {
        "name": "tnfr1",
        "maps_to": "oncology_sbml_hayashi2013_extended_tnf_induced_signaling_with_model2502170002_model.tnfr1",
        "description": "TNFR1 observable. Maps to SBML symbol `species_3`."
      },
      {
        "name": "ik_ba_nfkb",
        "maps_to": "oncology_sbml_hayashi2013_extended_tnf_induced_signaling_with_model2502170002_model.ik_ba_nfkb",
        "description": "IkBa NFkb observable. Maps to SBML symbol `species_1`."
      },
      {
        "name": "mapk",
        "maps_to": "oncology_sbml_hayashi2013_extended_tnf_induced_signaling_with_model2502170002_model.mapk",
        "description": "MAPK observable. Maps to SBML symbol `species_13`."
      },
      {
        "name": "nfk_bc",
        "maps_to": "oncology_sbml_hayashi2013_extended_tnf_induced_signaling_with_model2502170002_model.nfk_bc",
        "description": "NFkBc observable. Maps to SBML symbol `species_2`."
      },
      {
        "name": "traf6",
        "maps_to": "oncology_sbml_hayashi2013_extended_tnf_induced_signaling_with_model2502170002_model.traf6",
        "description": "TRAF6 observable. Maps to SBML symbol `species_6`."
      },
      {
        "name": "traf5",
        "maps_to": "oncology_sbml_hayashi2013_extended_tnf_induced_signaling_with_model2502170002_model.traf5",
        "description": "TRAF5 observable. Maps to SBML symbol `species_7`."
      },
      {
        "name": "state",
        "maps_to": "oncology_sbml_hayashi2013_extended_tnf_induced_signaling_with_model2502170002_model.state",
        "description": "Full raw SBML observable record for reproducibility and downstream visualisation."
      },
      {
        "name": "summary",
        "maps_to": "oncology_sbml_hayashi2013_extended_tnf_induced_signaling_with_model2502170002_model.summary",
        "description": "Change and peak summary across the simulated SBML observables."
      },
      {
        "name": "species_labels",
        "maps_to": "oncology_sbml_hayashi2013_extended_tnf_induced_signaling_with_model2502170002_model.species_labels",
        "description": "Mapping from selected raw SBML observable symbols to display labels."
      }
    ]
  },
  "tags": [
    "biomodels_ebi",
    "curated",
    "drug-response",
    "faithful",
    "oncology",
    "pharmacology",
    "physiology",
    "sbml",
    "signal-transduction",
    "signaling",
    "systemsbiology",
    "tumor-growth"
  ],
  "title": "Hayashi2013 - Extended TNF-induced Signaling with Gene Expression Dynamics (Model B) Lab",
  "models": [
    {
      "path": "models/core",
      "alias": "oncology_sbml_hayashi2013_extended_tnf_induced_signaling_with_model2502170002_model"
    },
    {
      "path": "models/visualisation",
      "alias": "visualisation"
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.oncology_sbml_hayashi2013_extended_tnf_induced_signaling_with_model2502170002_model_state"
      ],
      "from": "oncology_sbml_hayashi2013_extended_tnf_induced_signaling_with_model2502170002_model.state"
    },
    {
      "to": [
        "visualisation.oncology_sbml_hayashi2013_extended_tnf_induced_signaling_with_model2502170002_model_summary"
      ],
      "from": "oncology_sbml_hayashi2013_extended_tnf_induced_signaling_with_model2502170002_model.summary"
    },
    {
      "to": [
        "visualisation.oncology_sbml_hayashi2013_extended_tnf_induced_signaling_with_model2502170002_model_species_labels"
      ],
      "from": "oncology_sbml_hayashi2013_extended_tnf_induced_signaling_with_model2502170002_model.species_labels"
    }
  ],
  "package": "hayashi2013-extended-tnf-induced-signaling-with-gene-ex-a346a0c7",
  "runtime": {
    "duration": 10,
    "initial_inputs": {},
    "communication_step": 1
  },
  "version": "1.0.0",
  "description": "Hayashi2013 - Extended TNF-induced Signaling with Gene Expression Dynamics (Model B)Tumor necrosis factor (TNF) plays a crucial role in inflammation and is associated with diseases such as rheumatoid. It can be used to explore tumor-related dynamics and compare treatment-response behavior across conditions.",
  "schema_version": "2.0"
}