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Kremers2015 Thrombin Inhibitor Kinetics Lab

About lab

Mathematical model of thrombin inhibition by ATIII, alpha-2-macroglobulin and miscellaneous serpins (a1-antitrypsin, a1-proteinase inhibitor, a1-antichymotrypsin, protease nexin-1, C1inhibitor and oth. It can be used to explore systemsbiology kremers2015 thrombin inhibitor kinetics model1808210001 dynamics and compare simulation behavior across conditions.

Runtime

Duration1
Comms Step0.1

Runs

Total0
Completed0
Failed0

Metadata

Packagekremers2015-thrombin-inhibitor-kinetics-lab
Created2026-05-17
Updated2026-05-17
pharmacologysystemsbiologysbmlbiomodels_ebifaithfulcuratedvisualisation

Manifest

{
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        "label": "Initial A2 M",
        "maps_to": "systemsbiology_sbml_kremers2015_thrombin_inhibitor_kinetics_model1808210001_model.initial_a2_m",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `a2M`."
      },
      {
        "name": "initial_t_a2_m",
        "label": "Initial T A2 M",
        "maps_to": "systemsbiology_sbml_kremers2015_thrombin_inhibitor_kinetics_model1808210001_model.initial_t_a2_m",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `T_a2M`."
      },
      {
        "name": "initial_t_ms",
        "label": "Initial T Ms",
        "maps_to": "systemsbiology_sbml_kremers2015_thrombin_inhibitor_kinetics_model1808210001_model.initial_t_ms",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `T_MS`."
      },
      {
        "name": "initial_t_at",
        "label": "Initial T At",
        "maps_to": "systemsbiology_sbml_kremers2015_thrombin_inhibitor_kinetics_model1808210001_model.initial_t_at",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `T_AT`."
      },
      {
        "name": "initial_model_state_at",
        "label": "Initial Model State At",
        "maps_to": "systemsbiology_sbml_kremers2015_thrombin_inhibitor_kinetics_model1808210001_model.initial_model_state_at",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `AT`."
      },
      {
        "name": "initial_model_state_ms",
        "label": "Initial Model State Ms",
        "maps_to": "systemsbiology_sbml_kremers2015_thrombin_inhibitor_kinetics_model1808210001_model.initial_model_state_ms",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `MS`."
      }
    ],
    "outputs": [
      {
        "name": "state",
        "maps_to": "systemsbiology_sbml_kremers2015_thrombin_inhibitor_kinetics_model1808210001_model.state"
      },
      {
        "name": "summary",
        "maps_to": "systemsbiology_sbml_kremers2015_thrombin_inhibitor_kinetics_model1808210001_model.summary"
      },
      {
        "name": "species_labels",
        "maps_to": "systemsbiology_sbml_kremers2015_thrombin_inhibitor_kinetics_model1808210001_model.species_labels"
      },
      {
        "name": "a2_m",
        "maps_to": "systemsbiology_sbml_kremers2015_thrombin_inhibitor_kinetics_model1808210001_model.a2_m"
      },
      {
        "name": "t_a2_m",
        "maps_to": "systemsbiology_sbml_kremers2015_thrombin_inhibitor_kinetics_model1808210001_model.t_a2_m"
      },
      {
        "name": "t_ms",
        "maps_to": "systemsbiology_sbml_kremers2015_thrombin_inhibitor_kinetics_model1808210001_model.t_ms"
      },
      {
        "name": "t_at",
        "maps_to": "systemsbiology_sbml_kremers2015_thrombin_inhibitor_kinetics_model1808210001_model.t_at"
      },
      {
        "name": "model_state_at",
        "maps_to": "systemsbiology_sbml_kremers2015_thrombin_inhibitor_kinetics_model1808210001_model.model_state_at"
      },
      {
        "name": "model_state_ms",
        "maps_to": "systemsbiology_sbml_kremers2015_thrombin_inhibitor_kinetics_model1808210001_model.model_state_ms"
      }
    ]
  },
  "tags": [
    "pharmacology",
    "systemsbiology",
    "sbml",
    "biomodels_ebi",
    "faithful",
    "curated"
  ],
  "title": "Kremers2015 Thrombin Inhibitor Kinetics Lab",
  "models": [
    {
      "path": "owned/models/systemsbiology_sbml_kremers2015_thrombin_inhibitor_kinetics_model1808210001_model",
      "alias": "systemsbiology_sbml_kremers2015_thrombin_inhibitor_kinetics_model1808210001_model",
      "provenance": {
        "owned_path": "owned/models/systemsbiology_sbml_kremers2015_thrombin_inhibitor_kinetics_model1808210001_model"
      }
    },
    {
      "path": "owned/models/visualisation",
      "alias": "visualisation",
      "provenance": {
        "owned_path": "owned/models/visualisation"
      }
    }
  ],
  "wiring": [
    {
      "to": [
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      "from": "systemsbiology_sbml_kremers2015_thrombin_inhibitor_kinetics_model1808210001_model.state"
    },
    {
      "to": [
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      ],
      "from": "systemsbiology_sbml_kremers2015_thrombin_inhibitor_kinetics_model1808210001_model.summary"
    },
    {
      "to": [
        "visualisation.systemsbiology_sbml_kremers2015_thrombin_inhibitor_kinetics_model1808210001_model_species_labels"
      ],
      "from": "systemsbiology_sbml_kremers2015_thrombin_inhibitor_kinetics_model1808210001_model.species_labels"
    }
  ],
  "runtime": {
    "duration": 1,
    "initial_inputs": {},
    "communication_step": 0.1
  },
  "description": "Mathematical model of thrombin inhibition by ATIII, alpha-2-macroglobulin and miscellaneous serpins (a1-antitrypsin, a1-proteinase inhibitor, a1-antichymotrypsin, protease nexin-1, C1inhibitor and oth. It can be used to explore systemsbiology kremers2015 thrombin inhibitor kinetics model1808210001 dynamics and compare simulation behavior across conditions.",
  "schema_version": "2.0"
}

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