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Larsen2004 Calciumspiking Lab

About lab

This model is from the article: On the encoding and decoding of calcium signals in hepatocytes Ann Zahle Larsen, Lars Folke Olsen and Ursula Kummera Biophysical Chemistry Volume 107, Issue 1, 1 Januar. It can be used to explore systemsbiology larsen2004 calciumspiking BioModels0000000330 dynamics and compare simulation behavior across conditions.

Runtime

Duration1
Comms Step0.1

Runs

Total0
Completed0
Failed0

Metadata

Packagelarsen2004-calciumspiking-lab
Created2026-05-17
Updated2026-05-17
physiologysystemsbiologysbmlbiomodels_ebifaithfulcuratedvisualisation

Manifest

{
  "io": {
    "inputs": [
      {
        "name": "initial_calcium_er",
        "label": "Initial Calcium Er",
        "maps_to": "systemsbiology_sbml_larsen2004_calciumspiking_biomd0000000330_model.initial_calcium_er",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `Ca_ER`."
      },
      {
        "name": "initial_g_alpha",
        "label": "Initial G Alpha",
        "maps_to": "systemsbiology_sbml_larsen2004_calciumspiking_biomd0000000330_model.initial_g_alpha",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `G_alpha`."
      },
      {
        "name": "initial_calcium_cyt",
        "label": "Initial Calcium Cyt",
        "maps_to": "systemsbiology_sbml_larsen2004_calciumspiking_biomd0000000330_model.initial_calcium_cyt",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `Ca_cyt`."
      },
      {
        "name": "initial_calcium_mit",
        "label": "Initial Calcium Mit",
        "maps_to": "systemsbiology_sbml_larsen2004_calciumspiking_biomd0000000330_model.initial_calcium_mit",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `Ca_mit`."
      },
      {
        "name": "initial_model_state_plc",
        "label": "Initial Model State Plc",
        "maps_to": "systemsbiology_sbml_larsen2004_calciumspiking_biomd0000000330_model.initial_model_state_plc",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `PLC`."
      }
    ],
    "outputs": [
      {
        "name": "state",
        "maps_to": "systemsbiology_sbml_larsen2004_calciumspiking_biomd0000000330_model.state"
      },
      {
        "name": "summary",
        "maps_to": "systemsbiology_sbml_larsen2004_calciumspiking_biomd0000000330_model.summary"
      },
      {
        "name": "species_labels",
        "maps_to": "systemsbiology_sbml_larsen2004_calciumspiking_biomd0000000330_model.species_labels"
      },
      {
        "name": "calcium_er",
        "maps_to": "systemsbiology_sbml_larsen2004_calciumspiking_biomd0000000330_model.calcium_er"
      },
      {
        "name": "g_alpha",
        "maps_to": "systemsbiology_sbml_larsen2004_calciumspiking_biomd0000000330_model.g_alpha"
      },
      {
        "name": "calcium_cyt",
        "maps_to": "systemsbiology_sbml_larsen2004_calciumspiking_biomd0000000330_model.calcium_cyt"
      },
      {
        "name": "calcium_mit",
        "maps_to": "systemsbiology_sbml_larsen2004_calciumspiking_biomd0000000330_model.calcium_mit"
      },
      {
        "name": "plc",
        "maps_to": "systemsbiology_sbml_larsen2004_calciumspiking_biomd0000000330_model.plc"
      }
    ]
  },
  "tags": [
    "physiology",
    "systemsbiology",
    "sbml",
    "biomodels_ebi",
    "faithful",
    "curated"
  ],
  "title": "Larsen2004 Calciumspiking Lab",
  "models": [
    {
      "path": "owned/models/systemsbiology_sbml_larsen2004_calciumspiking_biomd0000000330_model",
      "alias": "systemsbiology_sbml_larsen2004_calciumspiking_biomd0000000330_model",
      "provenance": {
        "owned_path": "owned/models/systemsbiology_sbml_larsen2004_calciumspiking_biomd0000000330_model"
      }
    },
    {
      "path": "owned/models/visualisation",
      "alias": "visualisation",
      "provenance": {
        "owned_path": "owned/models/visualisation"
      }
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.systemsbiology_sbml_larsen2004_calciumspiking_biomd0000000330_model_state"
      ],
      "from": "systemsbiology_sbml_larsen2004_calciumspiking_biomd0000000330_model.state"
    },
    {
      "to": [
        "visualisation.systemsbiology_sbml_larsen2004_calciumspiking_biomd0000000330_model_summary"
      ],
      "from": "systemsbiology_sbml_larsen2004_calciumspiking_biomd0000000330_model.summary"
    },
    {
      "to": [
        "visualisation.systemsbiology_sbml_larsen2004_calciumspiking_biomd0000000330_model_species_labels"
      ],
      "from": "systemsbiology_sbml_larsen2004_calciumspiking_biomd0000000330_model.species_labels"
    }
  ],
  "runtime": {
    "duration": 1,
    "initial_inputs": {},
    "communication_step": 0.1
  },
  "description": "This model is from the article: On the encoding and decoding of calcium signals in hepatocytes Ann Zahle Larsen, Lars Folke Olsen and Ursula Kummera Biophysical Chemistry Volume 107, Issue 1, 1 Januar. It can be used to explore systemsbiology larsen2004 calciumspiking BioModels0000000330 dynamics and compare simulation behavior across conditions.",
  "schema_version": "2.0"
}

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