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Lemaire2004 - Mathematical Interactions Between Osteoblast Osteoclast Lab

About lab

Source-faithful physiology lab for Lemaire, Tobin, Greller, Cho, Suva, 2004. Public controls and outputs are mapped to real source symbols for bone and endocrine physiology.

Runtime

Duration0.01
Comms Step0.01
Settle Steps1

Runs

Total0
Completed0
Failed0

Metadata

Packagelemaire2004-mathematical-interactions-between-osteoblast-osteocl
Created2026-05-23
Updated2026-05-23
physiologycellmlphysiomefaithfulvisualisationother

Manifest

{
  "io": {
    "inputs": [
      {
        "name": "initial_active_osteoblasts",
        "label": "Initial Active Osteoblasts",
        "maps_to": "physiology_cellml_lemaire_tobin_greller_cho_suva_2004_lemairetobingrellerchosuva2004_model.initial_active_osteoblasts",
        "description": "Initial value for Active Osteoblasts. Maps to source symbol `B`. Units: picomolar. Naming evidence: source metadata names `B` as `active osteoblasts`.",
        "accepted_units": [
          "picomolar"
        ]
      },
      {
        "name": "initial_active_osteoclasts",
        "label": "Initial Active Osteoclasts",
        "maps_to": "physiology_cellml_lemaire_tobin_greller_cho_suva_2004_lemairetobingrellerchosuva2004_model.initial_active_osteoclasts",
        "description": "Initial value for Active Osteoclasts. Maps to source symbol `C`. Units: picomolar. Naming evidence: source metadata names `C` as `active osteoclasts`.",
        "accepted_units": [
          "picomolar"
        ]
      }
    ],
    "outputs": [
      {
        "name": "state",
        "label": "Selected Source State",
        "maps_to": "physiology_cellml_lemaire_tobin_greller_cho_suva_2004_lemairetobingrellerchosuva2004_model.state"
      },
      {
        "name": "summary",
        "label": "Simulation Summary",
        "maps_to": "physiology_cellml_lemaire_tobin_greller_cho_suva_2004_lemairetobingrellerchosuva2004_model.summary"
      },
      {
        "name": "trajectory",
        "label": "Source Trajectory",
        "maps_to": "physiology_cellml_lemaire_tobin_greller_cho_suva_2004_lemairetobingrellerchosuva2004_model.trajectory"
      },
      {
        "name": "variable_labels",
        "label": "Observable Labels",
        "maps_to": "physiology_cellml_lemaire_tobin_greller_cho_suva_2004_lemairetobingrellerchosuva2004_model.variable_labels"
      },
      {
        "name": "active_osteoblasts",
        "label": "Active Osteoblasts",
        "maps_to": "physiology_cellml_lemaire_tobin_greller_cho_suva_2004_lemairetobingrellerchosuva2004_model.active_osteoblasts",
        "description": "Active Osteoblasts. Maps to source symbol `B`. Units: picomolar. Naming evidence: source metadata names `B` as `active osteoblasts`."
      },
      {
        "name": "active_osteoclasts",
        "label": "Active Osteoclasts",
        "maps_to": "physiology_cellml_lemaire_tobin_greller_cho_suva_2004_lemairetobingrellerchosuva2004_model.active_osteoclasts",
        "description": "Active Osteoclasts. Maps to source symbol `C`. Units: picomolar. Naming evidence: source metadata names `C` as `active osteoclasts`."
      },
      {
        "name": "responding_osteoblasts",
        "label": "Responding Osteoblasts",
        "maps_to": "physiology_cellml_lemaire_tobin_greller_cho_suva_2004_lemairetobingrellerchosuva2004_model.responding_osteoblasts",
        "description": "Responding Osteoblasts. Maps to source symbol `R`. Units: picomolar. Naming evidence: source metadata names `R` as `responding osteoblasts`."
      },
      {
        "name": "c_s_concentration",
        "label": "C S Concentration",
        "maps_to": "physiology_cellml_lemaire_tobin_greller_cho_suva_2004_lemairetobingrellerchosuva2004_model.c_s_concentration",
        "description": "C S Concentration. Maps to source symbol `C_s`. Units: picomolar. Naming evidence: source symbol, component, or units provide a direct public name."
      },
      {
        "name": "concentration_p_0",
        "label": "Concentration P 0 (source P_0)",
        "maps_to": "physiology_cellml_lemaire_tobin_greller_cho_suva_2004_lemairetobingrellerchosuva2004_model.concentration_p_0",
        "description": "Concentration P 0 (source P_0). Maps to source symbol `P_0`. Units: picomolar. Naming evidence: amount concentration units identify a concentration state."
      },
      {
        "name": "concentration_p_s",
        "label": "Concentration P S (source P_s)",
        "maps_to": "physiology_cellml_lemaire_tobin_greller_cho_suva_2004_lemairetobingrellerchosuva2004_model.concentration_p_s",
        "description": "Concentration P S (source P_s). Maps to source symbol `P_s`. Units: picomolar. Naming evidence: amount concentration units identify a concentration state."
      }
    ]
  },
  "title": "Lemaire2004 - Mathematical Interactions Between Osteoblast Osteoclast Lab",
  "models": [
    {
      "path": "owned/models/physiology_cellml_lemaire_tobin_greller_cho_suva_2004_lemairetobingrellerchosuva2004_model",
      "alias": "physiology_cellml_lemaire_tobin_greller_cho_suva_2004_lemairetobingrellerchosuva2004_model",
      "parameters": {
        "model_path": "data/lemaire_tobin_greller_cho_suva_2004.cellml",
        "integration_step": 0.01
      },
      "provenance": {
        "owned_path": "owned/models/physiology_cellml_lemaire_tobin_greller_cho_suva_2004_lemairetobingrellerchosuva2004_model"
      }
    },
    {
      "path": "owned/models/visualisation",
      "alias": "visualisation",
      "provenance": {
        "owned_path": "owned/models/visualisation"
      }
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.physiology_cellml_lemaire_tobin_greller_cho_suva_2004_lemairetobingrellerchosuva2004_model_state"
      ],
      "from": "physiology_cellml_lemaire_tobin_greller_cho_suva_2004_lemairetobingrellerchosuva2004_model.state"
    },
    {
      "to": [
        "visualisation.physiology_cellml_lemaire_tobin_greller_cho_suva_2004_lemairetobingrellerchosuva2004_model_summary"
      ],
      "from": "physiology_cellml_lemaire_tobin_greller_cho_suva_2004_lemairetobingrellerchosuva2004_model.summary"
    },
    {
      "to": [
        "visualisation.physiology_cellml_lemaire_tobin_greller_cho_suva_2004_lemairetobingrellerchosuva2004_model_trajectory"
      ],
      "from": "physiology_cellml_lemaire_tobin_greller_cho_suva_2004_lemairetobingrellerchosuva2004_model.trajectory"
    },
    {
      "to": [
        "visualisation.physiology_cellml_lemaire_tobin_greller_cho_suva_2004_lemairetobingrellerchosuva2004_model_variable_labels"
      ],
      "from": "physiology_cellml_lemaire_tobin_greller_cho_suva_2004_lemairetobingrellerchosuva2004_model.variable_labels"
    }
  ],
  "runtime": {
    "duration": 0.01,
    "settle_steps": 1,
    "initial_inputs": {},
    "communication_step": 0.01
  },
  "description": "Source-faithful physiology lab for Lemaire, Tobin, Greller, Cho, Suva, 2004. Public controls and outputs are mapped to real source symbols for bone and endocrine physiology.",
  "schema_version": "2.0"
}

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