Kholodenko2000 - Ultrasensitivity and negative feedback bring oscillations in MAPK cascade Lab

{
  "io": {
    "inputs": [
      {
        "name": "initial_mos_kinase",
        "label": "Initial Mos kinase",
        "maps_to": "signaling_sbml_kholodenko2000_ultrasensitivity_and_negative_fee_biomd0000000010_model.initial_mos_kinase",
        "description": "Initial level of Mos kinase. Maps to SBML symbol `MKKK`; exposed as a traceable initial-condition perturbation."
      }
    ],
    "outputs": [
      {
        "name": "source_defined_erk2_state",
        "label": "source-defined ERK2 state",
        "maps_to": "signaling_sbml_kholodenko2000_ultrasensitivity_and_negative_fee_biomd0000000010_model.source_defined_erk2_state",
        "description": "source-defined ERK2 state. Maps to SBML symbol `MAPK` and is emitted in native SBML units."
      },
      {
        "name": "erk2_p",
        "label": "Erk2 P",
        "maps_to": "signaling_sbml_kholodenko2000_ultrasensitivity_and_negative_fee_biomd0000000010_model.erk2_p",
        "description": "Erk2 P. Maps to SBML symbol `MAPK_P` and is emitted in native SBML units."
      },
      {
        "name": "erk2_pp",
        "label": "Erk2 PP",
        "maps_to": "signaling_sbml_kholodenko2000_ultrasensitivity_and_negative_fee_biomd0000000010_model.erk2_pp",
        "description": "Erk2 PP. Maps to SBML symbol `MAPK_PP` and is emitted in native SBML units."
      },
      {
        "name": "state",
        "label": "Observable state",
        "maps_to": "signaling_sbml_kholodenko2000_ultrasensitivity_and_negative_fee_biomd0000000010_model.state"
      },
      {
        "name": "summary",
        "label": "Simulation summary",
        "maps_to": "signaling_sbml_kholodenko2000_ultrasensitivity_and_negative_fee_biomd0000000010_model.summary"
      },
      {
        "name": "species_labels",
        "label": "Observable labels",
        "maps_to": "signaling_sbml_kholodenko2000_ultrasensitivity_and_negative_fee_biomd0000000010_model.species_labels"
      }
    ]
  },
  "tags": [
    "signaling",
    "systems",
    "systems-biology",
    "sbml",
    "faithful",
    "biomodels_ebi",
    "mapk"
  ],
  "title": "Kholodenko2000 - Ultrasensitivity and negative feedback bring oscillations in MAPK cascade Lab",
  "models": [
    {
      "path": "models/core",
      "alias": "signaling_sbml_kholodenko2000_ultrasensitivity_and_negative_fee_biomd0000000010_model"
    },
    {
      "path": "models/visualisation",
      "alias": "visualisation"
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.signaling_sbml_kholodenko2000_ultrasensitivity_and_negative_fee_biomd0000000010_model_state"
      ],
      "from": "signaling_sbml_kholodenko2000_ultrasensitivity_and_negative_fee_biomd0000000010_model.state"
    },
    {
      "to": [
        "visualisation.signaling_sbml_kholodenko2000_ultrasensitivity_and_negative_fee_biomd0000000010_model_summary"
      ],
      "from": "signaling_sbml_kholodenko2000_ultrasensitivity_and_negative_fee_biomd0000000010_model.summary"
    },
    {
      "to": [
        "visualisation.signaling_sbml_kholodenko2000_ultrasensitivity_and_negative_fee_biomd0000000010_model_species_labels"
      ],
      "from": "signaling_sbml_kholodenko2000_ultrasensitivity_and_negative_fee_biomd0000000010_model.species_labels"
    }
  ],
  "package": "kholodenko2000-ultrasensitivity-and-negative-fee",
  "runtime": {
    "duration": 1,
    "initial_inputs": {},
    "communication_step": 0.1
  },
  "version": "1.0.0",
  "description": "Clean Biosimulant lab for MAPK/ERK receptor signaling. Values are native SBML quantities; equations, parameters, and initial values remain in the bundled source file.",
  "schema_version": "2.0"
}