Mears1997 - Evidence That Calcium Release Activated Current Mediates Lab

About lab

Mears1997 - Evidence That Calcium Release Activated Current Mediates Lab

Scientific Source

Source type: PhysioMe CellML
Upstream ID: physiome:mears_sheppard_atwater_rojas_bertram_sherman_1997
Original URL: https://models.physiomeproject.org/workspace/mears_sheppard_atwater_rojas_bertram_sherman_1997
Bundled artifact: data/mears_sheppard_atwater_rojas_bertram_sherman_1997.cellml

The bundled CellML/SBML artifact remains the scientific source of truth. This cleanup does not rewrite equations, parameters, units, or initial values; it exposes selected source symbols with conservative user-facing names.

Public Interface

Source-backed inputs:

initial_membrane_voltage (Membrane Voltage) maps to source symbol V; units: millivolt; evidence: source symbol, component, or units provide a direct public name.
initial_intracellular_calcium (Intracellular Calcium) maps to source symbol Ca_i; units: micromolar; evidence: source symbol, component, or units provide a direct public name.
The simulator still uses an internal integration_step parameter from the model manifest; it is not exposed as a biological lab input.

Selected outputs:

state, summary, trajectory, and variable_labels remain available for traceability.
potassium_conductance (Potassium Conductance) maps to source symbol g_K_ATP; units: picoS; evidence: source symbol, component, or units provide a direct public name.
potassium_current_i_k_atp (Potassium Current I K ATP) maps to source symbol i_K_ATP; units: picoA; evidence: source symbol, component, or units provide a direct public name.
membrane_voltage (Membrane Voltage) maps to source symbol V; units: millivolt; evidence: source symbol, component, or units provide a direct public name.
calcium_conductance (Calcium Conductance) maps to source symbol g_Ca_f; units: picoS; evidence: source symbol, component, or units provide a direct public name.
calcium_conductance_g_ca_s (Calcium Conductance G Ca S) maps to source symbol g_Ca_s; units: picoS; evidence: source symbol, component, or units provide a direct public name.
calcium_current (Calcium Current) maps to source symbol i_Ca; units: picoA; evidence: source symbol, component, or units provide a direct public name.

Ambiguous source symbols are intentionally given conservative names such as model_state_*, cell_population_*, or rate_constant_* rather than unsupported biological interpretations.

Visualisations

Visual scope: Membrane-voltage and gating-variable trajectories; ionic current ranking; action-potential response Q/A.

The visualisation renders a scientific Q/A table, selected source-variable trajectories, final observable values, and source/runtime evidence. The cards use runtime outputs from the core wrapper and suppress empty data.

Output Visualizations

01-mears1997-evidence-that-calcium-release-activated-current-mediates-lab-physiolog

02-selected-physiology-trajectories

03-selected-final-observable-values

04-source-and-runtime-evidence

Caveat

This validates source-faithful execution and Biosimulant wiring for electrophysiology; it does not claim clinical safety or full reproduction of every upstream figure.

Source-faithful physiology lab for Mears 1997. Public controls and outputs are mapped to real source symbols for electrophysiology.

Runtime

Duration0.01

Comms Step0.01

Settle Steps1

Runs

Total0

Completed0

Failed0

Metadata

Packagemears1997-evidence-that-calcium-release-activated-current-mediat

Created2026-05-23

Updated2026-05-23

physiologycellmlphysiomefaithfulvisualisationother

Manifest

{
  "io": {
    "inputs": [
      {
        "name": "initial_membrane_voltage",
        "label": "Initial Membrane Voltage",
        "maps_to": "physiology_cellml_mears_1997_mearssheppardatwaterrojasbertramsherman1997_model.initial_membrane_voltage",
        "description": "Initial value for Membrane Voltage. Maps to source symbol `V`. Units: millivolt. Naming evidence: source symbol, component, or units provide a direct public name.",
        "accepted_units": [
          "millivolt"
        ]
      },
      {
        "name": "initial_intracellular_calcium",
        "label": "Initial Intracellular Calcium",
        "maps_to": "physiology_cellml_mears_1997_mearssheppardatwaterrojasbertramsherman1997_model.initial_intracellular_calcium",
        "description": "Initial value for Intracellular Calcium. Maps to source symbol `Ca_i`. Units: micromolar. Naming evidence: source symbol, component, or units provide a direct public name.",
        "accepted_units": [
          "micromolar"
        ]
      }
    ],
    "outputs": [
      {
        "name": "state",
        "label": "Selected Source State",
        "maps_to": "physiology_cellml_mears_1997_mearssheppardatwaterrojasbertramsherman1997_model.state"
      },
      {
        "name": "summary",
        "label": "Simulation Summary",
        "maps_to": "physiology_cellml_mears_1997_mearssheppardatwaterrojasbertramsherman1997_model.summary"
      },
      {
        "name": "trajectory",
        "label": "Source Trajectory",
        "maps_to": "physiology_cellml_mears_1997_mearssheppardatwaterrojasbertramsherman1997_model.trajectory"
      },
      {
        "name": "variable_labels",
        "label": "Observable Labels",
        "maps_to": "physiology_cellml_mears_1997_mearssheppardatwaterrojasbertramsherman1997_model.variable_labels"
      },
      {
        "name": "potassium_conductance",
        "label": "Potassium Conductance",
        "maps_to": "physiology_cellml_mears_1997_mearssheppardatwaterrojasbertramsherman1997_model.potassium_conductance",
        "description": "Potassium Conductance. Maps to source symbol `g_K_ATP`. Units: picoS. Naming evidence: source symbol, component, or units provide a direct public name."
      },
      {
        "name": "potassium_current_i_k_atp",
        "label": "Potassium Current I K ATP",
        "maps_to": "physiology_cellml_mears_1997_mearssheppardatwaterrojasbertramsherman1997_model.potassium_current_i_k_atp",
        "description": "Potassium Current I K ATP. Maps to source symbol `i_K_ATP`. Units: picoA. Naming evidence: source symbol, component, or units provide a direct public name."
      },
      {
        "name": "membrane_voltage",
        "label": "Membrane Voltage",
        "maps_to": "physiology_cellml_mears_1997_mearssheppardatwaterrojasbertramsherman1997_model.membrane_voltage",
        "description": "Membrane Voltage. Maps to source symbol `V`. Units: millivolt. Naming evidence: source symbol, component, or units provide a direct public name."
      },
      {
        "name": "calcium_conductance",
        "label": "Calcium Conductance",
        "maps_to": "physiology_cellml_mears_1997_mearssheppardatwaterrojasbertramsherman1997_model.calcium_conductance",
        "description": "Calcium Conductance. Maps to source symbol `g_Ca_f`. Units: picoS. Naming evidence: source symbol, component, or units provide a direct public name."
      },
      {
        "name": "calcium_conductance_g_ca_s",
        "label": "Calcium Conductance G Ca S",
        "maps_to": "physiology_cellml_mears_1997_mearssheppardatwaterrojasbertramsherman1997_model.calcium_conductance_g_ca_s",
        "description": "Calcium Conductance G Ca S. Maps to source symbol `g_Ca_s`. Units: picoS. Naming evidence: source symbol, component, or units provide a direct public name."
      },
      {
        "name": "calcium_current",
        "label": "Calcium Current",
        "maps_to": "physiology_cellml_mears_1997_mearssheppardatwaterrojasbertramsherman1997_model.calcium_current",
        "description": "Calcium Current. Maps to source symbol `i_Ca`. Units: picoA. Naming evidence: source symbol, component, or units provide a direct public name."
      }
    ]
  },
  "title": "Mears1997 - Evidence That Calcium Release Activated Current Mediates Lab",
  "models": [
    {
      "path": "owned/models/physiology_cellml_mears_1997_mearssheppardatwaterrojasbertramsherman1997_model",
      "alias": "physiology_cellml_mears_1997_mearssheppardatwaterrojasbertramsherman1997_model",
      "parameters": {
        "model_path": "data/mears_sheppard_atwater_rojas_bertram_sherman_1997.cellml",
        "integration_step": 0.01
      },
      "provenance": {
        "owned_path": "owned/models/physiology_cellml_mears_1997_mearssheppardatwaterrojasbertramsherman1997_model"
      }
    },
    {
      "path": "owned/models/visualisation",
      "alias": "visualisation",
      "provenance": {
        "owned_path": "owned/models/visualisation"
      }
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.physiology_cellml_mears_1997_mearssheppardatwaterrojasbertramsherman1997_model_state"
      ],
      "from": "physiology_cellml_mears_1997_mearssheppardatwaterrojasbertramsherman1997_model.state"
    },
    {
      "to": [
        "visualisation.physiology_cellml_mears_1997_mearssheppardatwaterrojasbertramsherman1997_model_summary"
      ],
      "from": "physiology_cellml_mears_1997_mearssheppardatwaterrojasbertramsherman1997_model.summary"
    },
    {
      "to": [
        "visualisation.physiology_cellml_mears_1997_mearssheppardatwaterrojasbertramsherman1997_model_trajectory"
      ],
      "from": "physiology_cellml_mears_1997_mearssheppardatwaterrojasbertramsherman1997_model.trajectory"
    },
    {
      "to": [
        "visualisation.physiology_cellml_mears_1997_mearssheppardatwaterrojasbertramsherman1997_model_variable_labels"
      ],
      "from": "physiology_cellml_mears_1997_mearssheppardatwaterrojasbertramsherman1997_model.variable_labels"
    }
  ],
  "runtime": {
    "duration": 0.01,
    "settle_steps": 1,
    "initial_inputs": {},
    "communication_step": 0.01
  },
  "description": "Source-faithful physiology lab for Mears 1997. Public controls and outputs are mapped to real source symbols for electrophysiology.",
  "schema_version": "2.0"
}

Select a run from History to view its results.