Haiman2020 - Pyruvate Kinase Regulatory Model of Erythrocyte Glycolysis Lab

{
  "io": {
    "inputs": [
      {
        "name": "initial_d_glucose",
        "units": "native SBML value",
        "default": 1.24081917841505,
        "maps_to": "metabolism_sbml_haiman2020_pyruvate_kinase_regulatory_model_of_e_model2012150002_model.initial_d_glucose",
        "description": "Initial condition for d glucose. Maps to bundled SBML symbol `M_glc__D_c`. Applied before the Tellurium simulation starts; this does not change kinetic parameters or equations. Default from bundled SBML initial value."
      },
      {
        "name": "initial_d_glucose_6_phosphate",
        "units": "native SBML value",
        "default": 0.0602185259654985,
        "maps_to": "metabolism_sbml_haiman2020_pyruvate_kinase_regulatory_model_of_e_model2012150002_model.initial_d_glucose_6_phosphate",
        "description": "Initial condition for d glucose 6 phosphate. Maps to bundled SBML symbol `M_g6p_c`. Applied before the Tellurium simulation starts; this does not change kinetic parameters or equations. Default from bundled SBML initial value."
      },
      {
        "name": "initial_d_fructose_6_phosphate",
        "units": "native SBML value",
        "default": 0.0245635954921956,
        "maps_to": "metabolism_sbml_haiman2020_pyruvate_kinase_regulatory_model_of_e_model2012150002_model.initial_d_fructose_6_phosphate",
        "description": "Initial condition for d fructose 6 phosphate. Maps to bundled SBML symbol `M_f6p_c`. Applied before the Tellurium simulation starts; this does not change kinetic parameters or equations. Default from bundled SBML initial value."
      },
      {
        "name": "initial_d_fructose_1_6_bisphosphate",
        "units": "native SBML value",
        "default": 0.00923798760373767,
        "maps_to": "metabolism_sbml_haiman2020_pyruvate_kinase_regulatory_model_of_e_model2012150002_model.initial_d_fructose_1_6_bisphosphate",
        "description": "Initial condition for d fructose 1 6 bisphosphate. Maps to bundled SBML symbol `M_fdp_c`. Applied before the Tellurium simulation starts; this does not change kinetic parameters or equations. Default from bundled SBML initial value."
      },
      {
        "name": "initial_dihydroxyacetone_phosphate",
        "units": "native SBML value",
        "default": 0.130120897020308,
        "maps_to": "metabolism_sbml_haiman2020_pyruvate_kinase_regulatory_model_of_e_model2012150002_model.initial_dihydroxyacetone_phosphate",
        "description": "Initial condition for dihydroxyacetone phosphate. Maps to bundled SBML symbol `M_dhap_c`. Applied before the Tellurium simulation starts; this does not change kinetic parameters or equations. Default from bundled SBML initial value."
      }
    ],
    "outputs": [
      {
        "name": "d_glucose",
        "maps_to": "metabolism_sbml_haiman2020_pyruvate_kinase_regulatory_model_of_e_model2012150002_model.d_glucose"
      },
      {
        "name": "d_glucose_6_phosphate",
        "maps_to": "metabolism_sbml_haiman2020_pyruvate_kinase_regulatory_model_of_e_model2012150002_model.d_glucose_6_phosphate"
      },
      {
        "name": "d_fructose_6_phosphate",
        "maps_to": "metabolism_sbml_haiman2020_pyruvate_kinase_regulatory_model_of_e_model2012150002_model.d_fructose_6_phosphate"
      },
      {
        "name": "d_fructose_1_6_bisphosphate",
        "maps_to": "metabolism_sbml_haiman2020_pyruvate_kinase_regulatory_model_of_e_model2012150002_model.d_fructose_1_6_bisphosphate"
      },
      {
        "name": "dihydroxyacetone_phosphate",
        "maps_to": "metabolism_sbml_haiman2020_pyruvate_kinase_regulatory_model_of_e_model2012150002_model.dihydroxyacetone_phosphate"
      },
      {
        "name": "observable_values",
        "maps_to": "metabolism_sbml_haiman2020_pyruvate_kinase_regulatory_model_of_e_model2012150002_model.observable_values"
      },
      {
        "name": "run_summary",
        "maps_to": "metabolism_sbml_haiman2020_pyruvate_kinase_regulatory_model_of_e_model2012150002_model.run_summary"
      },
      {
        "name": "observable_labels",
        "maps_to": "metabolism_sbml_haiman2020_pyruvate_kinase_regulatory_model_of_e_model2012150002_model.observable_labels"
      }
    ]
  },
  "title": "Haiman2020 - Pyruvate Kinase Regulatory Model of Erythrocyte Glycolysis Lab",
  "models": [
    {
      "path": "models/core",
      "alias": "metabolism_sbml_haiman2020_pyruvate_kinase_regulatory_model_of_e_model2012150002_model",
      "parameters": {
        "model_path": "data/MODEL2012150002.xml",
        "integration_step": 0.1
      }
    },
    {
      "path": "models/visualisation",
      "alias": "visualisation"
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.metabolism_sbml_haiman2020_pyruvate_kinase_regulatory_model_of_e_model2012150002_model_observable_values"
      ],
      "from": "metabolism_sbml_haiman2020_pyruvate_kinase_regulatory_model_of_e_model2012150002_model.observable_values"
    },
    {
      "to": [
        "visualisation.metabolism_sbml_haiman2020_pyruvate_kinase_regulatory_model_of_e_model2012150002_model_run_summary"
      ],
      "from": "metabolism_sbml_haiman2020_pyruvate_kinase_regulatory_model_of_e_model2012150002_model.run_summary"
    },
    {
      "to": [
        "visualisation.metabolism_sbml_haiman2020_pyruvate_kinase_regulatory_model_of_e_model2012150002_model_observable_labels"
      ],
      "from": "metabolism_sbml_haiman2020_pyruvate_kinase_regulatory_model_of_e_model2012150002_model.observable_labels"
    }
  ],
  "package": "haiman2020-pyruvate-kinase-regulatory-model-of-erythroc-bacd10e9",
  "runtime": {
    "duration": 10,
    "initial_inputs": {},
    "communication_step": 1
  },
  "version": "1.0.0",
  "description": "Dynamic model utilizing mass action kinetics to elucidate network-level effects of allosteric regulation in erythrocyte metabolism. The pyruvate kinase regulatory model includes the glycolytic pathway.",
  "schema_version": "2.0"
}