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Nazaret2009 - Mitochondrial Energetic Metabolism Simplified Tca Cycle Lab

About lab

Source-faithful physiology lab for Nazaret, Heiske, Thurley and Mazat, 2009. Public controls and outputs are mapped to real source symbols for source-model physiology.

Runtime

Duration0.01
Comms Step0.01
Settle Steps1

Runs

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Completed0
Failed0

Metadata

Packagenazaret2009-mitochondrial-energetic-metabolism-simplified-tca-cy
Created2026-05-23
Updated2026-05-23
physiologycellmlphysiomefaithfulvisualisationother

Manifest

{
  "io": {
    "inputs": [
      {
        "name": "initial_membrane_potential",
        "label": "Initial Membrane Potential",
        "maps_to": "physiology_cellml_nazaret_heiske_thurley_and_mazat_2009_nazaretheiskethurleymazat2009_model.initial_membrane_potential",
        "description": "Initial value for Membrane Potential. Maps to source symbol `delta_psi`. Units: millivolt. Naming evidence: source metadata names `delta_psi` as `membrane potential`.",
        "accepted_units": [
          "millivolt"
        ]
      },
      {
        "name": "initial_adenosine_triphospahte",
        "label": "Initial Adenosine Triphospahte",
        "maps_to": "physiology_cellml_nazaret_heiske_thurley_and_mazat_2009_nazaretheiskethurleymazat2009_model.initial_adenosine_triphospahte",
        "description": "Initial value for Adenosine Triphospahte. Maps to source symbol `ATP`. Units: micromolar. Naming evidence: source metadata names `ATP` as `adenosine triphospahte`.",
        "accepted_units": [
          "micromolar"
        ]
      }
    ],
    "outputs": [
      {
        "name": "state",
        "label": "Selected Source State",
        "maps_to": "physiology_cellml_nazaret_heiske_thurley_and_mazat_2009_nazaretheiskethurleymazat2009_model.state"
      },
      {
        "name": "summary",
        "label": "Simulation Summary",
        "maps_to": "physiology_cellml_nazaret_heiske_thurley_and_mazat_2009_nazaretheiskethurleymazat2009_model.summary"
      },
      {
        "name": "trajectory",
        "label": "Source Trajectory",
        "maps_to": "physiology_cellml_nazaret_heiske_thurley_and_mazat_2009_nazaretheiskethurleymazat2009_model.trajectory"
      },
      {
        "name": "variable_labels",
        "label": "Observable Labels",
        "maps_to": "physiology_cellml_nazaret_heiske_thurley_and_mazat_2009_nazaretheiskethurleymazat2009_model.variable_labels"
      },
      {
        "name": "adenosine_triphospahte",
        "label": "Adenosine Triphospahte",
        "maps_to": "physiology_cellml_nazaret_heiske_thurley_and_mazat_2009_nazaretheiskethurleymazat2009_model.adenosine_triphospahte",
        "description": "Adenosine Triphospahte. Maps to source symbol `ATP`. Units: micromolar. Naming evidence: source metadata names `ATP` as `adenosine triphospahte`."
      },
      {
        "name": "atp_crit_delta_psi",
        "label": "ATP Crit Delta Psi",
        "maps_to": "physiology_cellml_nazaret_heiske_thurley_and_mazat_2009_nazaretheiskethurleymazat2009_model.atp_crit_delta_psi",
        "description": "ATP Crit Delta Psi. Maps to source symbol `ATP_crit_delta_psi`. Units: micromolar. Naming evidence: source symbol, component, or units provide a direct public name."
      },
      {
        "name": "atp_crit_delta_psi_f",
        "label": "ATP Crit Delta Psi F",
        "maps_to": "physiology_cellml_nazaret_heiske_thurley_and_mazat_2009_nazaretheiskethurleymazat2009_model.atp_crit_delta_psi_f",
        "description": "ATP Crit Delta Psi F. Maps to source symbol `F`. Units: coulomb_per_mole. Naming evidence: source symbol, component, or units provide a direct public name."
      },
      {
        "name": "atp_crit_delta_psi_pi",
        "label": "ATP Crit Delta Psi Pi",
        "maps_to": "physiology_cellml_nazaret_heiske_thurley_and_mazat_2009_nazaretheiskethurleymazat2009_model.atp_crit_delta_psi_pi",
        "description": "ATP Crit Delta Psi Pi. Maps to source symbol `Pi`. Units: millimolar. Naming evidence: source symbol, component, or units provide a direct public name."
      },
      {
        "name": "atp_crit_delta_psi_r",
        "label": "ATP Crit Delta Psi R",
        "maps_to": "physiology_cellml_nazaret_heiske_thurley_and_mazat_2009_nazaretheiskethurleymazat2009_model.atp_crit_delta_psi_r",
        "description": "ATP Crit Delta Psi R. Maps to source symbol `R`. Units: joule_per_mole_kelvin. Naming evidence: source symbol, component, or units provide a direct public name."
      },
      {
        "name": "atp_crit_delta_psi_t",
        "label": "ATP Crit Delta Psi T",
        "maps_to": "physiology_cellml_nazaret_heiske_thurley_and_mazat_2009_nazaretheiskethurleymazat2009_model.atp_crit_delta_psi_t",
        "description": "ATP Crit Delta Psi T. Maps to source symbol `T`. Units: kelvin. Naming evidence: source symbol, component, or units provide a direct public name."
      }
    ]
  },
  "title": "Nazaret2009 - Mitochondrial Energetic Metabolism Simplified Tca Cycle Lab",
  "models": [
    {
      "path": "owned/models/physiology_cellml_nazaret_heiske_thurley_and_mazat_2009_nazaretheiskethurleymazat2009_model",
      "alias": "physiology_cellml_nazaret_heiske_thurley_and_mazat_2009_nazaretheiskethurleymazat2009_model",
      "parameters": {
        "model_path": "data/nazaret_2009.cellml",
        "integration_step": 0.01
      },
      "provenance": {
        "owned_path": "owned/models/physiology_cellml_nazaret_heiske_thurley_and_mazat_2009_nazaretheiskethurleymazat2009_model"
      }
    },
    {
      "path": "owned/models/visualisation",
      "alias": "visualisation",
      "provenance": {
        "owned_path": "owned/models/visualisation"
      }
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.physiology_cellml_nazaret_heiske_thurley_and_mazat_2009_nazaretheiskethurleymazat2009_model_state"
      ],
      "from": "physiology_cellml_nazaret_heiske_thurley_and_mazat_2009_nazaretheiskethurleymazat2009_model.state"
    },
    {
      "to": [
        "visualisation.physiology_cellml_nazaret_heiske_thurley_and_mazat_2009_nazaretheiskethurleymazat2009_model_summary"
      ],
      "from": "physiology_cellml_nazaret_heiske_thurley_and_mazat_2009_nazaretheiskethurleymazat2009_model.summary"
    },
    {
      "to": [
        "visualisation.physiology_cellml_nazaret_heiske_thurley_and_mazat_2009_nazaretheiskethurleymazat2009_model_trajectory"
      ],
      "from": "physiology_cellml_nazaret_heiske_thurley_and_mazat_2009_nazaretheiskethurleymazat2009_model.trajectory"
    },
    {
      "to": [
        "visualisation.physiology_cellml_nazaret_heiske_thurley_and_mazat_2009_nazaretheiskethurleymazat2009_model_variable_labels"
      ],
      "from": "physiology_cellml_nazaret_heiske_thurley_and_mazat_2009_nazaretheiskethurleymazat2009_model.variable_labels"
    }
  ],
  "runtime": {
    "duration": 0.01,
    "settle_steps": 1,
    "initial_inputs": {},
    "communication_step": 0.01
  },
  "description": "Source-faithful physiology lab for Nazaret, Heiske, Thurley and Mazat, 2009. Public controls and outputs are mapped to real source symbols for source-model physiology.",
  "schema_version": "2.0"
}

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