Leon-Triana2020 - CAR T-cell therapy in B-cell acute lymphoblastic leukaemia with contribution from immature B cells Lab

{
  "io": {
    "inputs": [
      {
        "name": "initial_car_t_cells",
        "label": "Initial Car T Cells",
        "units": "native source value",
        "default": 10000000,
        "maps_to": "immunology_sbml_leon_triana2020_car_t_cell_therapy_in_b_cell_acu_biomd0000001012_model.initial_car_t_cells",
        "description": "Initial Car T Cells. Sets the initial value of bundled SBML species `CAR_T_cells`."
      },
      {
        "name": "initial_leukaemic_b_cells",
        "label": "Initial Leukaemic B Cells",
        "units": "native source value",
        "default": 50000000000,
        "maps_to": "immunology_sbml_leon_triana2020_car_t_cell_therapy_in_b_cell_acu_biomd0000001012_model.initial_leukaemic_b_cells",
        "description": "Initial Leukaemic B Cells. Sets the initial value of bundled SBML species `Leukaemic_B_cells`."
      },
      {
        "name": "initial_cells_healthy",
        "label": "Initial Cells Healthy",
        "units": "native source value",
        "default": 25000000000,
        "maps_to": "immunology_sbml_leon_triana2020_car_t_cell_therapy_in_b_cell_acu_biomd0000001012_model.initial_cells_healthy",
        "description": "Initial Cells Healthy. Sets the initial value of bundled SBML species `B_cells_healthy`."
      },
      {
        "name": "initial_cell_progenitors",
        "label": "Initial Cell Progenitors",
        "units": "native source value",
        "default": 10000000,
        "maps_to": "immunology_sbml_leon_triana2020_car_t_cell_therapy_in_b_cell_acu_biomd0000001012_model.initial_cell_progenitors",
        "description": "Initial Cell Progenitors. Sets the initial value of bundled SBML species `B_cell_progenitors`."
      },
      {
        "name": "cartcell_proliferation_rate",
        "label": "Cartcell Proliferation Rate",
        "units": "native source value",
        "default": 0.1,
        "maps_to": "immunology_sbml_leon_triana2020_car_t_cell_therapy_in_b_cell_acu_biomd0000001012_model.cartcell_proliferation_rate",
        "description": "Cartcell Proliferation Rate. Sets bundled SBML parameter `beta`."
      }
    ],
    "outputs": [
      {
        "name": "car_t_cells",
        "maps_to": "immunology_sbml_leon_triana2020_car_t_cell_therapy_in_b_cell_acu_biomd0000001012_model.car_t_cells"
      },
      {
        "name": "leukaemic_b_cells",
        "maps_to": "immunology_sbml_leon_triana2020_car_t_cell_therapy_in_b_cell_acu_biomd0000001012_model.leukaemic_b_cells"
      },
      {
        "name": "cells_healthy",
        "maps_to": "immunology_sbml_leon_triana2020_car_t_cell_therapy_in_b_cell_acu_biomd0000001012_model.cells_healthy"
      },
      {
        "name": "cell_progenitors",
        "maps_to": "immunology_sbml_leon_triana2020_car_t_cell_therapy_in_b_cell_acu_biomd0000001012_model.cell_progenitors"
      },
      {
        "name": "state",
        "maps_to": "immunology_sbml_leon_triana2020_car_t_cell_therapy_in_b_cell_acu_biomd0000001012_model.state"
      },
      {
        "name": "summary",
        "maps_to": "immunology_sbml_leon_triana2020_car_t_cell_therapy_in_b_cell_acu_biomd0000001012_model.summary"
      },
      {
        "name": "species_labels",
        "maps_to": "immunology_sbml_leon_triana2020_car_t_cell_therapy_in_b_cell_acu_biomd0000001012_model.species_labels"
      }
    ]
  },
  "title": "Leon-Triana2020 - CAR T-cell therapy in B-cell acute lymphoblastic leukaemia with contribution from immature B cells Lab",
  "models": [
    {
      "path": "owned/models/immunology_sbml_leon_triana2020_car_t_cell_therapy_in_b_cell_acu_biomd0000001012_model",
      "alias": "immunology_sbml_leon_triana2020_car_t_cell_therapy_in_b_cell_acu_biomd0000001012_model",
      "provenance": {
        "owned_path": "owned/models/immunology_sbml_leon_triana2020_car_t_cell_therapy_in_b_cell_acu_biomd0000001012_model"
      }
    },
    {
      "path": "owned/models/visualisation",
      "alias": "visualisation",
      "provenance": {
        "owned_path": "owned/models/visualisation"
      }
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.immunology_sbml_leon_triana2020_car_t_cell_therapy_in_b_cell_acu_biomd0000001012_model_state"
      ],
      "from": "immunology_sbml_leon_triana2020_car_t_cell_therapy_in_b_cell_acu_biomd0000001012_model.state"
    },
    {
      "to": [
        "visualisation.immunology_sbml_leon_triana2020_car_t_cell_therapy_in_b_cell_acu_biomd0000001012_model_summary"
      ],
      "from": "immunology_sbml_leon_triana2020_car_t_cell_therapy_in_b_cell_acu_biomd0000001012_model.summary"
    },
    {
      "to": [
        "visualisation.immunology_sbml_leon_triana2020_car_t_cell_therapy_in_b_cell_acu_biomd0000001012_model_species_labels"
      ],
      "from": "immunology_sbml_leon_triana2020_car_t_cell_therapy_in_b_cell_acu_biomd0000001012_model.species_labels"
    }
  ],
  "runtime": {
    "duration": 10,
    "initial_inputs": {},
    "communication_step": 1
  },
  "description": "This model is based on the publication:'CAR T cell therapy in B-cell acute lymphoblastic leukaemia: Insights from mathematical models'.Odelaisy León-Triana, Soukaina Sabir, Gabriel F. It can be used to explore immune response dynamics and compare pathway-level behavior across conditions.",
  "schema_version": "2.0"
}