Kimmel2021 - T cell competition and stochastic extinction events in CAR T cell therapy Lab

{
  "io": {
    "inputs": [
      {
        "name": "initial_antigen_presenting_tumor_cells",
        "label": "Antigen presenting tumour cells",
        "units": "native SBML value",
        "default": 94.86,
        "maps_to": "oncology_sbml_kimmel2021_t_cell_competition_and_stochastic_ext_biomd0000001041_model.initial_antigen_presenting_tumor_cells",
        "description": "Initial Antigen presenting tumour cells. Sets the initial value of bundled SBML symbol `Antigen_presenting_tumour_cells`."
      },
      {
        "name": "initial_normal_t_cells",
        "label": "Normal T cells",
        "units": "native SBML value",
        "default": 6,
        "maps_to": "oncology_sbml_kimmel2021_t_cell_competition_and_stochastic_ext_biomd0000001041_model.initial_normal_t_cells",
        "description": "Initial Normal T cells. Sets the initial value of bundled SBML symbol `Normal_T_cells`."
      },
      {
        "name": "initial_car_t_cells",
        "label": "CAR T cells",
        "units": "native SBML value",
        "default": 0.36,
        "maps_to": "oncology_sbml_kimmel2021_t_cell_competition_and_stochastic_ext_biomd0000001041_model.initial_car_t_cells",
        "description": "Initial CAR T cells. Sets the initial value of bundled SBML symbol `CAR_T_cells`."
      }
    ],
    "outputs": [
      {
        "name": "antigen_presenting_tumor_cells",
        "maps_to": "oncology_sbml_kimmel2021_t_cell_competition_and_stochastic_ext_biomd0000001041_model.antigen_presenting_tumor_cells",
        "description": "Antigen presenting tumour cells observable. Maps to SBML symbol `Antigen_presenting_tumour_cells`."
      },
      {
        "name": "normal_t_cells",
        "maps_to": "oncology_sbml_kimmel2021_t_cell_competition_and_stochastic_ext_biomd0000001041_model.normal_t_cells",
        "description": "Normal T cells observable. Maps to SBML symbol `Normal_T_cells`."
      },
      {
        "name": "car_t_cells",
        "maps_to": "oncology_sbml_kimmel2021_t_cell_competition_and_stochastic_ext_biomd0000001041_model.car_t_cells",
        "description": "CAR T cells observable. Maps to SBML symbol `CAR_T_cells`."
      },
      {
        "name": "state",
        "maps_to": "oncology_sbml_kimmel2021_t_cell_competition_and_stochastic_ext_biomd0000001041_model.state",
        "description": "Full raw SBML observable record for reproducibility and downstream visualisation."
      },
      {
        "name": "summary",
        "maps_to": "oncology_sbml_kimmel2021_t_cell_competition_and_stochastic_ext_biomd0000001041_model.summary",
        "description": "Change and peak summary across the simulated SBML observables."
      },
      {
        "name": "species_labels",
        "maps_to": "oncology_sbml_kimmel2021_t_cell_competition_and_stochastic_ext_biomd0000001041_model.species_labels",
        "description": "Mapping from selected raw SBML observable symbols to display labels."
      }
    ]
  },
  "tags": [
    "biomodels_ebi",
    "curated",
    "drug-response",
    "faithful",
    "immunology",
    "immunotherapy",
    "microenvironment",
    "oncology",
    "pharmacology",
    "physiology",
    "sbml",
    "systemsbiology",
    "tumor-growth"
  ],
  "title": "Kimmel2021 - T cell competition and stochastic extinction events in CAR T cell therapy Lab",
  "models": [
    {
      "path": "models/core",
      "alias": "oncology_sbml_kimmel2021_t_cell_competition_and_stochastic_ext_biomd0000001041_model"
    },
    {
      "path": "models/visualisation",
      "alias": "visualisation"
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.oncology_sbml_kimmel2021_t_cell_competition_and_stochastic_ext_biomd0000001041_model_state"
      ],
      "from": "oncology_sbml_kimmel2021_t_cell_competition_and_stochastic_ext_biomd0000001041_model.state"
    },
    {
      "to": [
        "visualisation.oncology_sbml_kimmel2021_t_cell_competition_and_stochastic_ext_biomd0000001041_model_summary"
      ],
      "from": "oncology_sbml_kimmel2021_t_cell_competition_and_stochastic_ext_biomd0000001041_model.summary"
    },
    {
      "to": [
        "visualisation.oncology_sbml_kimmel2021_t_cell_competition_and_stochastic_ext_biomd0000001041_model_species_labels"
      ],
      "from": "oncology_sbml_kimmel2021_t_cell_competition_and_stochastic_ext_biomd0000001041_model.species_labels"
    }
  ],
  "package": "kimmel2021-t-cell-competition-and-stochastic-extinction-cae6bf6a",
  "runtime": {
    "duration": 10,
    "initial_inputs": {},
    "communication_step": 1
  },
  "version": "1.0.0",
  "description": "This mathematical model of T cell-tumour interactions considering the roles of T cell competition and stochastic extinction events in CAR T cell therapy is described by the publication:Kimmel GJ, Lock. It can be used to explore tumor-related dynamics and compare treatment-response behavior across conditions.",
  "schema_version": "2.0"
}