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Whitcomb2004 Bicarbonate Pancreas Lab

About lab

A mathematical model of the pancreatic duct cell generating high bicarbonate concentrations in pancreatic juice David C Whitcomb, G Bard Ermentrout, Pancreas 2004 29:e30-40; PubMedID: 15257112 Abstrac. It can be used to explore systemsbiology whitcomb2004 bicarbonate pancreas BioModels0000000327 dynamics and compare simulation behavior across conditions.

Runtime

Duration1
Comms Step0.1

Runs

Total0
Completed0
Failed0

Metadata

Packagewhitcomb2004-bicarbonate-pancreas-lab
Created2026-05-17
Updated2026-05-17
generegulationimmunologyphysiologysystemsbiologysbmlbiomodels_ebifaithfulcuratedvisualisation

Manifest

{
  "io": {
    "inputs": [
      {
        "name": "initial_model_state_na",
        "label": "Initial Model State Na",
        "maps_to": "systemsbiology_sbml_whitcomb2004_bicarbonate_pancreas_biomd0000000327_model.initial_model_state_na",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `nb`."
      },
      {
        "name": "initial_model_state_cl",
        "label": "Initial Model State Cl",
        "maps_to": "systemsbiology_sbml_whitcomb2004_bicarbonate_pancreas_biomd0000000327_model.initial_model_state_cl",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `cb`."
      },
      {
        "name": "initial_model_state_cl_2",
        "label": "Initial Model State Cl 2",
        "maps_to": "systemsbiology_sbml_whitcomb2004_bicarbonate_pancreas_biomd0000000327_model.initial_model_state_cl_2",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `ci`."
      },
      {
        "name": "initial_hco3",
        "label": "Initial Hco3",
        "maps_to": "systemsbiology_sbml_whitcomb2004_bicarbonate_pancreas_biomd0000000327_model.initial_hco3",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `bl`."
      },
      {
        "name": "initial_hco3_2",
        "label": "Initial Hco3 2",
        "maps_to": "systemsbiology_sbml_whitcomb2004_bicarbonate_pancreas_biomd0000000327_model.initial_hco3_2",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `bb`."
      },
      {
        "name": "initial_hco3_3",
        "label": "Initial Hco3 3",
        "maps_to": "systemsbiology_sbml_whitcomb2004_bicarbonate_pancreas_biomd0000000327_model.initial_hco3_3",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `bi`."
      }
    ],
    "outputs": [
      {
        "name": "state",
        "maps_to": "systemsbiology_sbml_whitcomb2004_bicarbonate_pancreas_biomd0000000327_model.state"
      },
      {
        "name": "summary",
        "maps_to": "systemsbiology_sbml_whitcomb2004_bicarbonate_pancreas_biomd0000000327_model.summary"
      },
      {
        "name": "species_labels",
        "maps_to": "systemsbiology_sbml_whitcomb2004_bicarbonate_pancreas_biomd0000000327_model.species_labels"
      },
      {
        "name": "model_state_na",
        "maps_to": "systemsbiology_sbml_whitcomb2004_bicarbonate_pancreas_biomd0000000327_model.model_state_na"
      },
      {
        "name": "model_state_cl",
        "maps_to": "systemsbiology_sbml_whitcomb2004_bicarbonate_pancreas_biomd0000000327_model.model_state_cl"
      },
      {
        "name": "model_state_cl_2",
        "maps_to": "systemsbiology_sbml_whitcomb2004_bicarbonate_pancreas_biomd0000000327_model.model_state_cl_2"
      },
      {
        "name": "hco3",
        "maps_to": "systemsbiology_sbml_whitcomb2004_bicarbonate_pancreas_biomd0000000327_model.hco3"
      },
      {
        "name": "hco3_2",
        "maps_to": "systemsbiology_sbml_whitcomb2004_bicarbonate_pancreas_biomd0000000327_model.hco3_2"
      },
      {
        "name": "hco3_3",
        "maps_to": "systemsbiology_sbml_whitcomb2004_bicarbonate_pancreas_biomd0000000327_model.hco3_3"
      }
    ]
  },
  "tags": [
    "generegulation",
    "immunology",
    "physiology",
    "systemsbiology",
    "sbml",
    "biomodels_ebi",
    "faithful",
    "curated"
  ],
  "title": "Whitcomb2004 Bicarbonate Pancreas Lab",
  "models": [
    {
      "path": "owned/models/systemsbiology_sbml_whitcomb2004_bicarbonate_pancreas_biomd0000000327_model",
      "alias": "systemsbiology_sbml_whitcomb2004_bicarbonate_pancreas_biomd0000000327_model",
      "provenance": {
        "owned_path": "owned/models/systemsbiology_sbml_whitcomb2004_bicarbonate_pancreas_biomd0000000327_model"
      }
    },
    {
      "path": "owned/models/visualisation",
      "alias": "visualisation",
      "provenance": {
        "owned_path": "owned/models/visualisation"
      }
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.systemsbiology_sbml_whitcomb2004_bicarbonate_pancreas_biomd0000000327_model_state"
      ],
      "from": "systemsbiology_sbml_whitcomb2004_bicarbonate_pancreas_biomd0000000327_model.state"
    },
    {
      "to": [
        "visualisation.systemsbiology_sbml_whitcomb2004_bicarbonate_pancreas_biomd0000000327_model_summary"
      ],
      "from": "systemsbiology_sbml_whitcomb2004_bicarbonate_pancreas_biomd0000000327_model.summary"
    },
    {
      "to": [
        "visualisation.systemsbiology_sbml_whitcomb2004_bicarbonate_pancreas_biomd0000000327_model_species_labels"
      ],
      "from": "systemsbiology_sbml_whitcomb2004_bicarbonate_pancreas_biomd0000000327_model.species_labels"
    }
  ],
  "runtime": {
    "duration": 1,
    "initial_inputs": {},
    "communication_step": 0.1
  },
  "description": "A mathematical model of the pancreatic duct cell generating high bicarbonate concentrations in pancreatic juice David C Whitcomb, G Bard Ermentrout, Pancreas 2004 29:e30-40; PubMedID: 15257112 Abstrac. It can be used to explore systemsbiology whitcomb2004 bicarbonate pancreas BioModels0000000327 dynamics and compare simulation behavior across conditions.",
  "schema_version": "2.0"
}

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