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Alharbi2019 - Tumor-normal model (TNM) of the development of tumor cells and their impact on normal cell dynamics Lab

About lab

This ordinary differential equation model of the interactions between tumor and normal cells is based on the publication:S. It can be used to explore tumor-related dynamics and compare treatment-response behavior across conditions.

Runtime

Duration10
Comms Step1

Runs

Total0
Completed0
Failed0

Metadata

Packagealharbi2019-tumor-normal-model-tnm-of-the-development-of-tumor-c
Created2026-05-16
Updated2026-05-16
biomodels_ebicurateddrug-responsefaithfuloncologypharmacologyphysiologysbmlsystemsbiologytumor-growthvisualisation

Manifest

{
  "io": {
    "inputs": [
      {
        "name": "initial_tumor_cells",
        "label": "Tumor cells",
        "units": "native SBML value",
        "default": 1,
        "maps_to": "oncology_sbml_alharbi2019_tumor_normal_model_tnm_of_the_develo_biomd0000001037_model.initial_tumor_cells",
        "description": "Initial Tumor cells. Sets the initial value of bundled SBML symbol `Tumor_cells`."
      },
      {
        "name": "initial_normal_cells",
        "label": "Normal cells",
        "units": "native SBML value",
        "default": 1,
        "maps_to": "oncology_sbml_alharbi2019_tumor_normal_model_tnm_of_the_develo_biomd0000001037_model.initial_normal_cells",
        "description": "Initial Normal cells. Sets the initial value of bundled SBML symbol `Normal_cells`."
      }
    ],
    "outputs": [
      {
        "name": "tumor_cells",
        "maps_to": "oncology_sbml_alharbi2019_tumor_normal_model_tnm_of_the_develo_biomd0000001037_model.tumor_cells",
        "description": "Tumor cells observable. Maps to SBML symbol `Tumor_cells`."
      },
      {
        "name": "normal_cells",
        "maps_to": "oncology_sbml_alharbi2019_tumor_normal_model_tnm_of_the_develo_biomd0000001037_model.normal_cells",
        "description": "Normal cells observable. Maps to SBML symbol `Normal_cells`."
      },
      {
        "name": "state",
        "maps_to": "oncology_sbml_alharbi2019_tumor_normal_model_tnm_of_the_develo_biomd0000001037_model.state",
        "description": "Full raw SBML observable record for reproducibility and downstream visualisation."
      },
      {
        "name": "summary",
        "maps_to": "oncology_sbml_alharbi2019_tumor_normal_model_tnm_of_the_develo_biomd0000001037_model.summary",
        "description": "Change and peak summary across the simulated SBML observables."
      },
      {
        "name": "species_labels",
        "maps_to": "oncology_sbml_alharbi2019_tumor_normal_model_tnm_of_the_develo_biomd0000001037_model.species_labels",
        "description": "Mapping from selected raw SBML observable symbols to display labels."
      }
    ]
  },
  "tags": [
    "biomodels_ebi",
    "curated",
    "drug-response",
    "faithful",
    "oncology",
    "pharmacology",
    "physiology",
    "sbml",
    "systemsbiology",
    "tumor-growth"
  ],
  "title": "Alharbi2019 - Tumor-normal model (TNM) of the development of tumor cells and their impact on normal cell dynamics Lab",
  "models": [
    {
      "path": "owned/models/oncology_sbml_alharbi2019_tumor_normal_model_tnm_of_the_develo_biomd0000001037_model",
      "alias": "oncology_sbml_alharbi2019_tumor_normal_model_tnm_of_the_develo_biomd0000001037_model",
      "provenance": {
        "owned_path": "owned/models/oncology_sbml_alharbi2019_tumor_normal_model_tnm_of_the_develo_biomd0000001037_model"
      }
    },
    {
      "path": "owned/models/visualisation",
      "alias": "visualisation",
      "provenance": {
        "owned_path": "owned/models/visualisation"
      }
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.oncology_sbml_alharbi2019_tumor_normal_model_tnm_of_the_develo_biomd0000001037_model_state"
      ],
      "from": "oncology_sbml_alharbi2019_tumor_normal_model_tnm_of_the_develo_biomd0000001037_model.state"
    },
    {
      "to": [
        "visualisation.oncology_sbml_alharbi2019_tumor_normal_model_tnm_of_the_develo_biomd0000001037_model_summary"
      ],
      "from": "oncology_sbml_alharbi2019_tumor_normal_model_tnm_of_the_develo_biomd0000001037_model.summary"
    },
    {
      "to": [
        "visualisation.oncology_sbml_alharbi2019_tumor_normal_model_tnm_of_the_develo_biomd0000001037_model_species_labels"
      ],
      "from": "oncology_sbml_alharbi2019_tumor_normal_model_tnm_of_the_develo_biomd0000001037_model.species_labels"
    }
  ],
  "runtime": {
    "duration": 10,
    "initial_inputs": {},
    "communication_step": 1
  },
  "description": "This ordinary differential equation model of the interactions between tumor and normal cells is based on the publication:S. It can be used to explore tumor-related dynamics and compare treatment-response behavior across conditions.",
  "schema_version": "2.0"
}

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